{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:44:42Z","timestamp":1791531882214,"version":"4.3.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Antimicrob. Chemother."],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1093\/jac\/dkv166","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T20:44:52Z","timestamp":1434660292000},"page":"2779-2786","source":"Crossref","is-referenced-by-count":184,"title":["OP0595, a new diazabicyclooctane: mode of action as a serine \u03b2-lactamase inhibitor, antibiotic and \u03b2-lactam \u2018enhancer\u2019"],"prefix":"10.1093","volume":"70","author":[{"given":"Akihiro","family":"Morinaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Tsutsumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mototsugu","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Abe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Furuuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiichi","family":"Inamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiaki","family":"Sakamaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakako","family":"Mitsuhashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Livermore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,6,18]]},"reference":[{"key":"2015091109281169000_70.10.2779.1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12023"},{"key":"2015091109281169000_70.10.2779.2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01009-09"},{"key":"2015091109281169000_70.10.2779.3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir202"},{"key":"2015091109281169000_70.10.2779.4","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70190-7"},{"key":"2015091109281169000_70.10.2779.5","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis588"},{"key":"2015091109281169000_70.10.2779.6","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00242"},{"key":"2015091109281169000_70.10.2779.7","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0013-7"},{"key":"2015091109281169000_70.10.2779.8","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00756-10"},{"key":"2015091109281169000_70.10.2779.9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.05927-11"},{"key":"2015091109281169000_70.10.2779.10","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt178"},{"key":"2015091109281169000_70.10.2779.11","unstructured":"Kano A , Koresawa T , Matsumoto K et al . First in human study to assess safety, tolerability and pharmacokinetics of \u03b2-lactamase inhibitor OP0595. In: Abstracts of the Twenty-fifth European Congress of Clinical Microbiology and Infectious Diseases, Copenhagen, 2015. Abstract P0236. ESCMID, Basel, Switzerland."},{"key":"2015091109281169000_70.10.2779.12","author":"Abe"},{"key":"2015091109281169000_70.10.2779.13","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks350"},{"key":"2015091109281169000_70.10.2779.14","volume-title":"Practical Protein Crystallography","author":"McRee","year":"1993"},{"key":"2015091109281169000_70.10.2779.15","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889897006766"},{"key":"2015091109281169000_70.10.2779.16","doi-asserted-by":"publisher","DOI":"10.1107\/S1600536810003314"},{"key":"2015091109281169000_70.10.2779.17","first-page":"240","article-title":"Refinement of macromolecular structures by the maximum-likelihood method","volume":"D53","author":"Murshudov","year":"1997","journal-title":"Acta Cryst"},{"key":"2015091109281169000_70.10.2779.18","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing: Twenty-fifth Informational Supplement M100-S25","author":"Clinical and Laboratory Standards Institute","year":"2015"},{"key":"2015091109281169000_70.10.2779.19","volume-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically\u2014Tenth Edition: Approved Standard M7-A10","author":"Clinical and Laboratory Standards Institute","year":"2015"},{"key":"2015091109281169000_70.10.2779.20","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.14.2.257"},{"key":"2015091109281169000_70.10.2779.21","doi-asserted-by":"publisher","DOI":"10.1159\/000071141"},{"key":"2015091109281169000_70.10.2779.22","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02247-12"},{"key":"2015091109281169000_70.10.2779.23","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03057-14"},{"key":"2015091109281169000_70.10.2779.24","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/16.3.287"},{"key":"2015091109281169000_70.10.2779.25","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01975-07"},{"key":"2015091109281169000_70.10.2779.26","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01740-07"},{"key":"2015091109281169000_70.10.2779.27","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1093\/jac\/16.6.719","article-title":"In-vitro activity of the combinations of ampicillin with mecillinam or with \u03b2-lactamase inhibitors against strains resistant to ampicillin","volume":"16","author":"Verbist","year":"1985","journal-title":"J Antimicrob Chemother"},{"key":"2015091109281169000_70.10.2779.28","doi-asserted-by":"publisher","DOI":"10.3109\/10408418209113505"},{"key":"2015091109281169000_70.10.2779.29","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.485979"},{"key":"2015091109281169000_70.10.2779.30","doi-asserted-by":"publisher","DOI":"10.1159\/000238542"},{"key":"2015091109281169000_70.10.2779.31","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.30.6.906"},{"key":"2015091109281169000_70.10.2779.32","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04819-14"},{"key":"2015091109281169000_70.10.2779.33","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1994.tb00482.x"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article\/70\/10\/2779\/829602\/OP0595-a-new-diazabicyclooctane-mode-of-action-as","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T10:04:57Z","timestamp":1498212297000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article-lookup\/doi\/10.1093\/jac\/dkv166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6,18]]},"references-count":33,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,9,11]]},"published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1093\/jac\/dkv166"],"URL":"https:\/\/doi.org\/10.1093\/jac\/dkv166","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,6,18]]}}}