{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:36:23Z","timestamp":1791905783282,"version":"4.3.4"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"10","funder":[{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Antimicrob. Chemother."],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1093\/jac\/dkv170","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T21:50:31Z","timestamp":1435787431000},"page":"2862-2869","source":"Crossref","is-referenced-by-count":124,"title":["Phase 1 study assessing the steady-state concentration of ceftazidime and avibactam in plasma and epithelial lining fluid following two dosing regimens"],"prefix":"10.1093","volume":"70","author":[{"given":"David P.","family":"Nicolau","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Siew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timi","family":"Edeki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Learoyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shampa","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,7,1]]},"reference":[{"key":"2015091109281163000_70.10.2862.1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1155\/2008\/593289","article-title":"Clinical practice guidelines for hospital-acquired pneumonia and ventilator-associated pneumonia in adults","volume":"19","author":"Rotstein","year":"2008","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"2015091109281163000_70.10.2862.2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200405-644ST"},{"key":"2015091109281163000_70.10.2862.3","doi-asserted-by":"publisher","DOI":"10.1586\/eri.12.36"},{"key":"2015091109281163000_70.10.2862.4","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks301"},{"key":"2015091109281163000_70.10.2862.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0904124"},{"key":"2015091109281163000_70.10.2862.6","doi-asserted-by":"publisher","DOI":"10.3201\/eid1710.110655"},{"key":"2015091109281163000_70.10.2862.7","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12023"},{"key":"2015091109281163000_70.10.2862.8","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01722-10"},{"key":"2015091109281163000_70.10.2862.9","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00756-10"},{"key":"2015091109281163000_70.10.2862.10","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00851-12"},{"key":"2015091109281163000_70.10.2862.11","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02161-13"},{"key":"2015091109281163000_70.10.2862.12","doi-asserted-by":"crossref","DOI":"10.4155\/bio.15.76","article-title":"Determination of avibactam and ceftazidime in human plasma samples by liquid chromatography and mass spectrometry","author":"Sill\u00e9n","year":"2015","journal-title":"Bioanalysis"},{"key":"2015091109281163000_70.10.2862.13","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00567-09"},{"key":"2015091109281163000_70.10.2862.14","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1152\/jappl.1986.60.2.532","article-title":"Estimation of volume of epithelial lining fluid recovered by lavage using urea as marker of dilution","volume":"60","author":"Rennard","year":"1986","journal-title":"J Appl Physiol (1985)"},{"key":"2015091109281163000_70.10.2862.15","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01463-13"},{"key":"2015091109281163000_70.10.2862.16","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks468"},{"key":"2015091109281163000_70.10.2862.17","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04627-14"},{"key":"2015091109281163000_70.10.2862.18","unstructured":"Berkhout J , Melchers MJ , Van Mil CH et al . Exposure response relationships of ceftazidime and avibactam in a neutropenic thigh model. In: Abstracts of the Fifty-third Interscience Conference on Antimicrobial Agents and Chemotherapy, Denver, CO, 2013 . Abstract A1023. American Society for Microbiology, Washington, DC, USA."},{"key":"2015091109281163000_70.10.2862.19","unstructured":"Edeki T , Armstrong J , Li J . Pharmacokinetics of avibactam (AVI) and ceftazidime (CAZ) following separate or combined administration in healthy volunteers. In: Abstracts of the Fifty-third Interscience Conference on Antimicrobial Agents and Chemotherapy, Denver, CO, 2013 . Abstract A1019. American Society for Microbiology, Washington, DC, USA."},{"key":"2015091109281163000_70.10.2862.20","unstructured":"Li J , Armstrong J , Edeki T . Pharmacokinetic (PK) drug interaction study of ceftazidime-avibactam (CAZ-AVI) and metronidazole (MTZ) in healthy volunteers. In: Abstracts of the Fifty-third Interscience Conference on Antimicrobial Agents and Chemotherapy, Denver, CO, 2013 . Abstract A-1020. American Society for Microbiology, Washington, DC, USA."},{"key":"2015091109281163000_70.10.2862.21","doi-asserted-by":"publisher","DOI":"10.1179\/joc.1995.7.1.50"},{"key":"2015091109281163000_70.10.2862.22","first-page":"7","article-title":"Antibiotic tissue concentrations: methodological aspects and interpretation of results","volume":"44","author":"Cars","year":"1985","journal-title":"Scand J Infect Dis Suppl"},{"key":"2015091109281163000_70.10.2862.23","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01330-10"},{"key":"2015091109281163000_70.10.2862.24","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-004-2171-2"},{"key":"2015091109281163000_70.10.2862.25","unstructured":"GlaxoSmithKline. Ceftazidime 1 g injection SPC. http:\/\/www.medicines.org.uk\/emc\/document.aspx?documentid=19176&docType=SPC ."},{"key":"2015091109281163000_70.10.2862.26","unstructured":"Li J , Zhou D , Al Huniti N et al . Pharmacokinetic\/pharmacodynamic target attainment (PTA) and cumulative fractions of response (CFR) for ceftazidime, ceftazidime-avibactam, and meropenem against bacteria isolated from patients in Europe in 2012. In: Abstracts of the Twenty-fourth European Congress of Clinical Microbiology and Infectious Diseases, Barcelona, 2014 . Abstract P1747A. European Society of Clinical Microbiology and Infectious Diseases, Basel."},{"key":"2015091109281163000_70.10.2862.27","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks523"},{"key":"2015091109281163000_70.10.2862.28","doi-asserted-by":"publisher","DOI":"10.1185\/03007995.2012.748653"},{"key":"2015091109281163000_70.10.2862.29","unstructured":"Mazuski JE , Gasink L , Armstrong J et al . Efficacy and safety of ceftazidime-avibactam plus metronidazole versus meropenem in the treatment of complicated intra-abdominal infection\u2014results from a Phase III program. In: Abstracts of the Twenty-fifth European Congress of Clinical Microbiology and Infectious Diseases, Copenhagen, 2015 . Abstract 1731. European Society of Clinical Microbiology and Infectious Diseases, Basel."},{"key":"2015091109281163000_70.10.2862.30","doi-asserted-by":"publisher","DOI":"10.1136\/thx.49.2.104"},{"key":"2015091109281163000_70.10.2862.31","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2015.01.009"},{"key":"2015091109281163000_70.10.2862.32","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.23.6.892"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jac\/article\/70\/10\/2862\/829935\/Phase-1-study-assessing-the-steadystate","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T18:32:01Z","timestamp":1566930721000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article-lookup\/doi\/10.1093\/jac\/dkv170"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,1]]},"references-count":32,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2015,9,11]]},"published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1093\/jac\/dkv170"],"URL":"https:\/\/doi.org\/10.1093\/jac\/dkv170","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,1]]}}}