{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:18:57Z","timestamp":1791425937336,"version":"4.3.3"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"11","funder":[{"DOI":"10.13039\/100000064","name":"National Center for Complementary and Alternative Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000064","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"American Lebanese Syrian Associated Charities (ALSAC), St Jude Children's Research Hospital"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Antimicrob. Chemother."],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1093\/jac\/dkv231","type":"journal-article","created":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T16:27:23Z","timestamp":1445531243000},"page":"3061-3069","source":"Crossref","is-referenced-by-count":31,"title":["Gastrointestinal localization of metronidazole by a lactobacilli-inspired tetramic acid motif improves treatment outcomes in the hamster model of<i>Clostridium difficile<\/i>infection"],"prefix":"10.1093","volume":"70","author":[{"given":"Philip T.","family":"Cherian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerrod S.","family":"Scarborough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aman P.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahidul A.","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard E.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian G.","family":"Hurdle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,8,18]]},"reference":[{"key":"2015102114375179000_70.11.3061.1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2174\/1568026613666131113154753","article-title":"Progress in the discovery of treatments for C. difficile infection: a clinical and medicinal chemistry review","volume":"14","author":"Tsutsumi","year":"2014","journal-title":"Curr Top Med Chem"},{"key":"2015102114375179000_70.11.3061.2","doi-asserted-by":"publisher","DOI":"10.1086\/651706"},{"key":"2015102114375179000_70.11.3061.3","doi-asserted-by":"publisher","DOI":"10.1086\/587656"},{"key":"2015102114375179000_70.11.3061.4","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu313"},{"key":"2015102114375179000_70.11.3061.5","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu316"},{"key":"2015102114375179000_70.11.3061.6","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr201"},{"key":"2015102114375179000_70.11.3061.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.02.069"},{"key":"2015102114375179000_70.11.3061.8","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1219899110"},{"key":"2015102114375179000_70.11.3061.9","doi-asserted-by":"publisher","DOI":"10.1021\/cb5001197"},{"key":"2015102114375179000_70.11.3061.10","doi-asserted-by":"publisher","DOI":"10.1021\/ja2041964"},{"key":"2015102114375179000_70.11.3061.11","doi-asserted-by":"crossref","first-page":"4721","DOI":"10.1038\/srep04721","article-title":"Chemical modulation of the biological activity of reutericyclin: a membrane-active antibiotic from Lactobacillus reuteri","volume":"4","author":"Cherian","year":"2014","journal-title":"Sci Rep"},{"key":"2015102114375179000_70.11.3061.12","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks493"},{"key":"2015102114375179000_70.11.3061.13","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00702-09"},{"key":"2015102114375179000_70.11.3061.14","doi-asserted-by":"publisher","DOI":"10.1016\/0040-4039(95)01316-A"},{"key":"2015102114375179000_70.11.3061.15","doi-asserted-by":"publisher","DOI":"10.1021\/ol0507930"},{"key":"2015102114375179000_70.11.3061.16","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1039\/JR9540000832","article-title":"Derivatives of acetoacetic acid. Part IV. A new route to \u03b1-acetyltetronic acids","author":"Lacey","year":"1954","journal-title":"J Chem Soc"},{"key":"2015102114375179000_70.11.3061.17","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1039\/JR9540000850","article-title":"Derivatives of acetoacetic acid. Part VII. \u03b1-Acetyltetramic acids","author":"Lacey","year":"1954","journal-title":"J Chem Soc"},{"key":"2015102114375179000_70.11.3061.18","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.10284"},{"key":"2015102114375179000_70.11.3061.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.02.009"},{"key":"2015102114375179000_70.11.3061.20","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.5570450343"},{"key":"2015102114375179000_70.11.3061.21","doi-asserted-by":"crossref","first-page":"3902","DOI":"10.1055\/s-2006-950310","article-title":"Phosphorus ylide based functionalizations of tetronic and tetramic acids","volume":"22","author":"Schobert","year":"2006","journal-title":"Synthesis"},{"key":"2015102114375179000_70.11.3061.22","doi-asserted-by":"publisher","DOI":"10.1021\/jo102304y"},{"key":"2015102114375179000_70.11.3061.23","doi-asserted-by":"publisher","DOI":"10.1111\/jam.12344"},{"key":"2015102114375179000_70.11.3061.24","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-009-0594-5"},{"key":"2015102114375179000_70.11.3061.25","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.10.3975-3979.2004"},{"key":"2015102114375179000_70.11.3061.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.05.021"},{"key":"2015102114375179000_70.11.3061.27","doi-asserted-by":"publisher","DOI":"10.3390\/molecules14041483"},{"key":"2015102114375179000_70.11.3061.28","doi-asserted-by":"publisher","DOI":"10.2174\/138161212799504858"},{"key":"2015102114375179000_70.11.3061.29","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21122"},{"key":"2015102114375179000_70.11.3061.30","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00551-09"},{"key":"2015102114375179000_70.11.3061.31","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8564199"},{"key":"2015102114375179000_70.11.3061.32","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(86)90552-6"},{"key":"2015102114375179000_70.11.3061.33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1302664110"},{"key":"2015102114375179000_70.11.3061.34","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21720"},{"key":"2015102114375179000_70.11.3061.35","doi-asserted-by":"publisher","DOI":"10.1086\/647939"},{"key":"2015102114375179000_70.11.3061.36","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6968.12367"},{"key":"2015102114375179000_70.11.3061.37","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00877-12"},{"key":"2015102114375179000_70.11.3061.38","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.it.2012.05.003","article-title":"Antibiotics, microbiota, and immune defense","volume":"33","author":"Ubeda","year":"2010","journal-title":"Trends Immunol"},{"key":"2015102114375179000_70.11.3061.39","doi-asserted-by":"publisher","DOI":"10.1021\/bi100523c"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/70\/11\/3061\/17429808\/dkv231.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T10:08:34Z","timestamp":1503569314000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article-lookup\/doi\/10.1093\/jac\/dkv231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,18]]},"references-count":39,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2015,10,12]]},"published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1093\/jac\/dkv231"],"URL":"https:\/\/doi.org\/10.1093\/jac\/dkv231","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,18]]}}}