{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:13:14Z","timestamp":1791421994655,"version":"4.3.3"},"reference-count":129,"publisher":"Oxford University Press (OUP)","issue":"1","funder":[{"name":"Robert Koch-Institute"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Antimicrob. Chemother."],"published-print":{"date-parts":[[2016,1]]},"DOI":"10.1093\/jac\/dkv285","type":"journal-article","created":{"date-parts":[[2015,10,4]],"date-time":"2015-10-04T00:17:59Z","timestamp":1443917879000},"page":"6-16","source":"Crossref","is-referenced-by-count":83,"title":["Database on natural polymorphisms and resistance-related non-synonymous mutations in thymidine kinase and DNA polymerase genes of herpes simplex virus types 1 and 2"],"prefix":"10.1093","volume":"71","author":[{"given":"Andreas","family":"Sauerbrei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Bohn-Wippert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Kaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andi","family":"Krumbholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Karrasch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Zell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,10,3]]},"reference":[{"key":"2015121606475079000_71.1.6.1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2003.005850"},{"key":"2015121606475079000_71.1.6.2","doi-asserted-by":"crossref","DOI":"10.2807\/ese.16.44.20005-en","article-title":"Seroprevalence of herpes simplex virus type 1 and type 2 in Thuringia, Germany, 1999 to 2006","volume":"16","author":"Sauerbrei","year":"2011","journal-title":"Euro Surveill"},{"key":"2015121606475079000_71.1.6.3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(200006)61:2<201::AID-JMV5>3.0.CO;2-P"},{"key":"2015121606475079000_71.1.6.4","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.2"},{"key":"2015121606475079000_71.1.6.5","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdj132"},{"key":"2015121606475079000_71.1.6.6","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1870"},{"issue":"Suppl 1","key":"2015121606475079000_71.1.6.7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/jmv.1890410512","article-title":"Sensitivity monitoring of clinical isolates of herpes simplex virus to acyclovir","volume":"12","author":"Collins","year":"1993","journal-title":"J Med Virol"},{"key":"2015121606475079000_71.1.6.8","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.1.242-249.2004"},{"key":"2015121606475079000_71.1.6.9","doi-asserted-by":"publisher","DOI":"10.1086\/590668"},{"key":"2015121606475079000_71.1.6.10","doi-asserted-by":"publisher","DOI":"10.1086\/606028"},{"key":"2015121606475079000_71.1.6.11","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00615-10"},{"key":"2015121606475079000_71.1.6.12","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/169.6.1338"},{"key":"2015121606475079000_71.1.6.13","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.163.1.76"},{"key":"2015121606475079000_71.1.6.14","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.antiviral.2014.08.013","article-title":"Resistance of herpes simplex viruses to acyclovir: an update from a ten-year survey in France","volume":"111C","author":"Frobert","year":"2014","journal-title":"Antiviral Res"},{"key":"2015121606475079000_71.1.6.15","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00977-15"},{"key":"2015121606475079000_71.1.6.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.09.012"},{"key":"2015121606475079000_71.1.6.17","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/135965350400900107","article-title":"Sequential switching of DNA polymerase and thymidine kinase-mediated HSV-1 drug resistance in an immunocompromised child","volume":"9","author":"Stranska","year":"2004","journal-title":"Antivir Ther"},{"key":"2015121606475079000_71.1.6.18","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.2.650-657.2004"},{"key":"2015121606475079000_71.1.6.19","doi-asserted-by":"publisher","DOI":"10.1086\/314900"},{"key":"2015121606475079000_71.1.6.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2014.03.015"},{"key":"2015121606475079000_71.1.6.21","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(02)00005-7"},{"key":"2015121606475079000_71.1.6.22","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.3.1055-1059.2005"},{"key":"2015121606475079000_71.1.6.23","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-64-3-523"},{"key":"2015121606475079000_71.1.6.24","doi-asserted-by":"publisher","DOI":"10.1016\/S1386-6532(02)00263-9"},{"key":"2015121606475079000_71.1.6.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.01.153"},{"key":"2015121606475079000_71.1.6.26","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1852"},{"key":"2015121606475079000_71.1.6.27","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00669-10"},{"key":"2015121606475079000_71.1.6.28","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-71-12-2979"},{"key":"2015121606475079000_71.1.6.29","doi-asserted-by":"publisher","DOI":"10.1021\/bi00094a019"},{"key":"2015121606475079000_71.1.6.30","doi-asserted-by":"crossref","first-page":"6584","DOI":"10.1016\/S0021-9258(19)50467-7","article-title":"Permissible amino acid substitutions within the putative nucleoside binding site of herpes simplex virus type 1 encoded thymidine kinase established by random sequence mutagenesis [corrected]","volume":"267","author":"Munir","year":"1992","journal-title":"J Biol Chem"},{"key":"2015121606475079000_71.1.6.31","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijmm.2015.08.014","article-title":"Resistance testing of clinical herpes simplex virus types 2 isolates collected over 4 decades","author":"Bohn-Wippert","year":"2015","journal-title":"Int J Med Microbiol"},{"key":"2015121606475079000_71.1.6.32","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1128\/JVI.50.3.733-738.1984","article-title":"Effects of deletions on expression of the herpes simplex virus thymidine kinase gene from the intact viral genome: the amino terminus of the enzyme is dispensable for catalytic activity","volume":"50","author":"Halpern","year":"1984","journal-title":"J Virol"},{"key":"2015121606475079000_71.1.6.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2013.03.014"},{"key":"2015121606475079000_71.1.6.34","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2003.08.018"},{"key":"2015121606475079000_71.1.6.35","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2012.08.001"},{"key":"2015121606475079000_71.1.6.36","doi-asserted-by":"publisher","DOI":"10.1086\/515626"},{"key":"2015121606475079000_71.1.6.37","doi-asserted-by":"publisher","DOI":"10.1086\/315696"},{"key":"2015121606475079000_71.1.6.38","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.18880-0"},{"key":"2015121606475079000_71.1.6.39","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.66.404"},{"key":"2015121606475079000_71.1.6.40","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.1787"},{"key":"2015121606475079000_71.1.6.41","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.37.24075"},{"key":"2015121606475079000_71.1.6.42","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.46.29245"},{"key":"2015121606475079000_71.1.6.43","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309848200"},{"key":"2015121606475079000_71.1.6.44","doi-asserted-by":"crossref","first-page":"7791","DOI":"10.1128\/JVI.71.10.7791-7798.1997","article-title":"Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity","volume":"71","author":"Hwang","year":"1997","journal-title":"J Virol"},{"key":"2015121606475079000_71.1.6.45","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-7646(02)00021-3"},{"key":"2015121606475079000_71.1.6.46","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1993.1439"},{"key":"2015121606475079000_71.1.6.47","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200101)63:1<57::AID-JMV1008>3.0.CO;2-9"},{"key":"2015121606475079000_71.1.6.48","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03360-14"},{"key":"2015121606475079000_71.1.6.49","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.6.1524-1529.2000"},{"key":"2015121606475079000_71.1.6.50","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90093-Q"},{"key":"2015121606475079000_71.1.6.51","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199312093292405"},{"key":"2015121606475079000_71.1.6.52","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2006.01.010"},{"key":"2015121606475079000_71.1.6.53","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1128\/JVI.53.2.477-488.1985","article-title":"Sensitivity of arabinosyladenine-resistant mutants of herpes simplex virus to other antiviral drugs and mapping of drug hypersensitivity mutations to the DNA polymerase locus","volume":"53","author":"Coen","year":"1985","journal-title":"J Virol"},{"key":"2015121606475079000_71.1.6.54","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.1.108"},{"key":"2015121606475079000_71.1.6.55","doi-asserted-by":"crossref","first-page":"5883","DOI":"10.1128\/JVI.64.12.5883-5890.1990","article-title":"Engineered herpes simplex virus DNA polymerase point mutants: the most highly conserved region shared among alpha-like DNA polymerases is involved in substrate recognition","volume":"64","author":"Marcy","year":"1990","journal-title":"J Virol"},{"key":"2015121606475079000_71.1.6.56","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.9.5863-5869.2005"},{"key":"2015121606475079000_71.1.6.57","doi-asserted-by":"publisher","DOI":"10.1086\/515375"},{"key":"2015121606475079000_71.1.6.58","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit437"},{"key":"2015121606475079000_71.1.6.59","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.77.14.7820-7829.2003"},{"key":"2015121606475079000_71.1.6.60","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.10.1483"},{"key":"2015121606475079000_71.1.6.61","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2013.09.008"},{"key":"2015121606475079000_71.1.6.62","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199810)56:2<151::AID-JMV9>3.0.CO;2-7"},{"key":"2015121606475079000_71.1.6.63","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20061"},{"key":"2015121606475079000_71.1.6.64","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(02)00131-6"},{"key":"2015121606475079000_71.1.6.65","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.4.1761-1769.2001"},{"key":"2015121606475079000_71.1.6.66","doi-asserted-by":"crossref","first-page":"3872","DOI":"10.1128\/JVI.71.5.3872-3878.1997","article-title":"Homopolymer mutational hot spots mediate herpes simplex virus resistance to acyclovir","volume":"71","author":"Sasadeusz","year":"1997","journal-title":"J Virol"},{"key":"2015121606475079000_71.1.6.67","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00889-06"},{"key":"2015121606475079000_71.1.6.68","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.5.1707-1713.2003"},{"key":"2015121606475079000_71.1.6.69","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2012.09.004"},{"key":"2015121606475079000_71.1.6.70","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2011.06.009"},{"key":"2015121606475079000_71.1.6.71","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000240081.19635.db"},{"key":"2015121606475079000_71.1.6.72","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00417-09"},{"key":"2015121606475079000_71.1.6.73","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.7.3105-3110.2001"},{"key":"2015121606475079000_71.1.6.74","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(82)90127-9"},{"key":"2015121606475079000_71.1.6.75","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(82)90044-4"},{"key":"2015121606475079000_71.1.6.76","doi-asserted-by":"publisher","DOI":"10.1093\/jpids\/pis009"},{"key":"2015121606475079000_71.1.6.77","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.20990"},{"key":"2015121606475079000_71.1.6.78","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(84)90119-9"},{"key":"2015121606475079000_71.1.6.79","doi-asserted-by":"publisher","DOI":"10.1016\/0168-1702(92)90105-I"},{"key":"2015121606475079000_71.1.6.80","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.29.5.894"},{"key":"2015121606475079000_71.1.6.81","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/j.1460-2075.1987.tb04735.x","article-title":"Related functional domains in virus DNA polymerases","volume":"6","author":"Larder","year":"1987","journal-title":"EMBO J"},{"key":"2015121606475079000_71.1.6.82","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-49-1-115"},{"key":"2015121606475079000_71.1.6.83","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/141.5.563"},{"key":"2015121606475079000_71.1.6.84","doi-asserted-by":"publisher","DOI":"10.1134\/S0026893310030118"},{"key":"2015121606475079000_71.1.6.85","doi-asserted-by":"publisher","DOI":"10.1016\/0092-1157(86)90004-1"},{"key":"2015121606475079000_71.1.6.86","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9071(200010)62:2<247::AID-JMV17>3.0.CO;2-V"},{"key":"2015121606475079000_71.1.6.87","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(88)90134-6"},{"key":"2015121606475079000_71.1.6.88","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2010.03.002"},{"key":"2015121606475079000_71.1.6.89","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2012.12.001"},{"key":"2015121606475079000_71.1.6.90","doi-asserted-by":"publisher","DOI":"10.4161\/viru.1.6.13806"},{"key":"2015121606475079000_71.1.6.91","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1177\/135965350400900413","article-title":"Genotypic and phenotypic characterization of acyclovir-resistant herpes simplex viruses isolated from haematopoietic stem cell transplant recipients","volume":"9","author":"Stranska","year":"2004","journal-title":"Antivir Ther"},{"key":"2015121606475079000_71.1.6.92","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.6.2331-2333.2004"},{"key":"2015121606475079000_71.1.6.93","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2004.04.002"},{"key":"2015121606475079000_71.1.6.94","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2005.11.004"},{"key":"2015121606475079000_71.1.6.95","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.10.1465"},{"key":"2015121606475079000_71.1.6.96","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-75-7-1743"},{"key":"2015121606475079000_71.1.6.97","doi-asserted-by":"publisher","DOI":"10.1006\/expr.1996.4115"},{"key":"2015121606475079000_71.1.6.98","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/13.6.529"},{"key":"2015121606475079000_71.1.6.99","doi-asserted-by":"publisher","DOI":"10.1086\/315387"},{"key":"2015121606475079000_71.1.6.100","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-81-3-639"},{"key":"2015121606475079000_71.1.6.101","doi-asserted-by":"publisher","DOI":"10.1007\/BF01379080"},{"key":"2015121606475079000_71.1.6.102","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1177\/135965350701200502","article-title":"DNA polymerase mutations in drug-resistant herpes simplex virus mutants determine in vivo neurovirulence and drug-enzyme interactions","volume":"12","author":"Andrei","year":"2007","journal-title":"Antivir Ther"},{"key":"2015121606475079000_71.1.6.103","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-3542(97)00054-5"},{"key":"2015121606475079000_71.1.6.104","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2009.00874.x"},{"key":"2015121606475079000_71.1.6.105","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.38.6.1246"},{"key":"2015121606475079000_71.1.6.106","doi-asserted-by":"publisher","DOI":"10.1007\/BF01708615"},{"key":"2015121606475079000_71.1.6.107","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02247-12"},{"key":"2015121606475079000_71.1.6.108","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.2.606-611.2005"},{"key":"2015121606475079000_71.1.6.109","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.18.6672"},{"key":"2015121606475079000_71.1.6.110","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jit019"},{"key":"2015121606475079000_71.1.6.111","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.10175"},{"key":"2015121606475079000_71.1.6.112","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.22.1.71"},{"key":"2015121606475079000_71.1.6.113","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.3.476"},{"key":"2015121606475079000_71.1.6.114","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-76-12-2999"},{"key":"2015121606475079000_71.1.6.115","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/18.5.1207"},{"key":"2015121606475079000_71.1.6.116","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1998.9201"},{"key":"2015121606475079000_71.1.6.117","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00632-09"},{"key":"2015121606475079000_71.1.6.118","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2006.08.001"},{"key":"2015121606475079000_71.1.6.119","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-77-7-1521"},{"key":"2015121606475079000_71.1.6.120","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1046\/j.1432-1327.1998.2550472.x","article-title":"Drug resistance of herpes simplex virus type 1. Structural considerations at the molecular level of the thymidine kinase","volume":"225","author":"Kussmann-Gerber","year":"1998","journal-title":"Eur J Biochem"},{"key":"2015121606475079000_71.1.6.121","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1128\/JVI.40.2.456-464.1981","article-title":"Control of expression of the vaccinia virus thymidine kinase gene","volume":"40","author":"Hruby","year":"1981","journal-title":"J Virol"},{"key":"2015121606475079000_71.1.6.122","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.45.31967"},{"key":"2015121606475079000_71.1.6.123","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(63)90071-X"},{"key":"2015121606475079000_71.1.6.124","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(88)90308-X"},{"key":"2015121606475079000_71.1.6.125","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2012.09.016"},{"key":"2015121606475079000_71.1.6.126","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jis237"},{"key":"2015121606475079000_71.1.6.127","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2012.07.001"},{"key":"2015121606475079000_71.1.6.128","doi-asserted-by":"publisher","DOI":"10.1038\/nsb1095-876"},{"key":"2015121606475079000_71.1.6.129","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602414200"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/71\/1\/6\/16863469\/dkv285.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,22]],"date-time":"2022-05-22T17:01:44Z","timestamp":1653238904000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article-lookup\/doi\/10.1093\/jac\/dkv285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,3]]},"references-count":129,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,12,16]]},"published-print":{"date-parts":[[2016,1]]}},"alternative-id":["10.1093\/jac\/dkv285"],"URL":"https:\/\/doi.org\/10.1093\/jac\/dkv285","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,3]]}}}