{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T17:25:09Z","timestamp":1791307509518,"version":"4.3.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To describe the outcome and risk factors for treatment failure of 76 Gram-negative bacilli (GNB) prosthetic joint infections (PJIs) managed with a curative intent according to a standardized protocol derived from published guidelines.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analysed data from all the cases of GNB-PJI treated surgically over an 8 year period. Treatment failure was defined as persistence or recurrence of PJI signs during follow-up, resulting in additional surgery and\/or antibiotic administration or death.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Treatment failure within the follow-up period (median\u200a=\u200a2.6 years) was observed in 16 of 76 (21.1%) patients. The failure rate was similar whether the patients were treated with fluoroquinolones in the whole cohort (22.4% versus 16.7%, P\u200a=\u200a0.75) and after stratification according to the surgical procedure. The low failure rate observed in patients not receiving fluoroquinolones might be explained by the standardized attitude of maintaining intravenous \u03b2-lactams throughout treatment duration (median\u200a=\u200a90 days). In multivariate analysis, C-reactive protein level \u2265175 mg\/L was significantly associated with treatment failure (adjusted HR\u200a=\u200a7.75, 95% CI\u200a=\u200a2.66\u201322.59, P\u200a&lt;\u200a0.0001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Management according to standardized procedures may improve the prognosis of GNB-PJI. Intravenous \u03b2-lactams, continued for 3 months, should be considered an effective alternative to fluoroquinolones.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkw202","type":"journal-article","created":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T00:08:46Z","timestamp":1465430926000},"page":"2593-2597","source":"Crossref","is-referenced-by-count":33,"title":["Gram-negative prosthetic joint infections managed according to a multidisciplinary standardized approach: risk factors for failure and outcome with and without fluoroquinolones"],"prefix":"10.1093","volume":"71","author":[{"given":"O.","family":"Grossi","sequence":"first","affiliation":[{"name":"Service des Maladies Infectieuses, Centre Hospitalier Universitaire, 1 place Alexis Ricordeau, 44093 Nantes cedex 1, France"},{"name":"D\u00e9partement de M\u00e9decine Interne - Infectiologie, Nouvelles Cliniques Nantaises, 3 rue Eric Tabarly, 44277 Nantes cedex 2, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Asseray","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses, Centre Hospitalier Universitaire, 1 place Alexis Ricordeau, 44093 Nantes cedex 1, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bourigault","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Gestion du Risque Infectieux, Centre Hospitalier Universitaire, 1 place Alexis Ricordeau, 44093 Nantes cedex 1, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Corvec","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie, Centre Hospitalier Universitaire, 1 place Alexis Ricordeau, 44093 Nantes cedex 1, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Valette","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses, Centre Hospitalier Universitaire, 1 place Alexis Ricordeau, 44093 Nantes cedex 1, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Navas","sequence":"additional","affiliation":[{"name":"Service de Pharmacie Clinique, Centre Hospitalier Universitaire, 1 place Alexis Ricordeau, 44093 Nantes cedex 1, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Happi-Djeukou","sequence":"additional","affiliation":[{"name":"Clinique Chirurgicale Orthop\u00e9dique et Traumatologique, Centre Hospitalier Universitaire, 1 place Alexis Ricordeau, 44093 Nantes cedex 1, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Touchais","sequence":"additional","affiliation":[{"name":"Clinique Chirurgicale Orthop\u00e9dique et Traumatologique, Centre Hospitalier Universitaire, 1 place Alexis Ricordeau, 44093 Nantes cedex 1, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"B\u00e9mer","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie, Centre Hospitalier Universitaire, 1 place Alexis Ricordeau, 44093 Nantes cedex 1, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Boutoille","sequence":"additional","affiliation":[{"name":"Service des Maladies Infectieuses, Centre Hospitalier Universitaire, 1 place Alexis Ricordeau, 44093 Nantes cedex 1, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,6,7]]},"reference":[{"key":"2019092716314146900_DKW202C1","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1128\/CMR.00111-13","article-title":"Prosthetic joint infection","volume":"27","author":"Tande","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"2019092716314146900_DKW202C2","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1056\/NEJMra040181","article-title":"Prosthetic-joint infections","volume":"351","author":"Zimmerli","year":"2004","journal-title":"N Engl J Med"},{"key":"2019092716314146900_DKW202C3","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1086\/605593","article-title":"Gram-negative prosthetic joint infections: risk factors and outcome of treatment","volume":"49","author":"Hsieh","year":"2009","journal-title":"Clin Infect Dis"},{"key":"2019092716314146900_DKW202C4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.arth.2011.03.044","article-title":"Prosthetic joint infection caused by Gram-negative organisms","volume":"26","author":"Zmistowski","year":"2011","journal-title":"J Arthroplasty"},{"key":"2019092716314146900_DKW202C5","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1469-0691.2010.03361.x","article-title":"Gram-negative prosthetic joint infection treated with debridement, prosthesis retention and antibiotic regimens including a fluoroquinolone","volume":"17","author":"Aboltins","year":"2011","journal-title":"Clin Microbiol Infect"},{"key":"2019092716314146900_DKW202C6","doi-asserted-by":"crossref","first-page":"4772","DOI":"10.1128\/AAC.00188-09","article-title":"Outcome of acute prosthetic joint infections due to Gram-negative bacilli treated with open debridement and retention of the prosthesis","volume":"53","author":"Mart\u00ednez-Pastor","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"2019092716314146900_DKW202C7","doi-asserted-by":"crossref","first-page":"O911","DOI":"10.1111\/1469-0691.12649","article-title":"Gram-negative prosthetic joint infection: outcome of a debridement, antibiotics and implant retention approach. A large multicentre study","volume":"20","author":"Rodr\u00edguez-Pardo","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"2019092716314146900_DKW202C8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1586\/14787210.2015.999669","article-title":"An update on surgical and antimicrobial therapy for acute periprosthetic joint infection: new challenges for the present and the future","volume":"13","author":"Rodr\u00edguez-Pardo","year":"2015","journal-title":"Expert Rev Anti Infect Ther"},{"key":"2019092716314146900_DKW202C9","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1086\/529436","article-title":"Treatment of joint prosthesis infection in accordance with current recommendations improves outcome","volume":"46","author":"Betsch","year":"2008","journal-title":"Clin Infect Dis"},{"key":"2019092716314146900_DKW202C10","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/cid\/cis803","article-title":"Diagnosis and management of prosthetic joint infection: clinical practice guidelines by the Infectious Diseases Society of America","volume":"56","author":"Osmon","year":"2013","journal-title":"Clin Infect Dis"},{"key":"2019092716314146900_DKW202C11","first-page":"815","article-title":"[Clinical practice recommendations. Osteoarticular infections on materials (prosthesis, implant, osteosynthesis)]","volume":"39","author":"Soci\u00e9t\u00e9 de Pathologie Infectieuse de Langue Fran\u00e7aise","year":"2009","journal-title":"Med Mal Infect"},{"issue":"Suppl 1","key":"2019092716314146900_DKW202C12","doi-asserted-by":"crossref","first-page":"S75","DOI":"10.2106\/00004623-200300001-00014","article-title":"Diagnosis and management of infection after total knee arthroplasty","volume":"85","author":"Tsukayama","year":"2003","journal-title":"J Bone Joint Surg Am"},{"key":"2019092716314146900_DKW202C13","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1086\/499234","article-title":"Outcome of prosthetic joint infections treated with debridement and retention of components","volume":"42","author":"Marculescu","year":"2006","journal-title":"Clin Infect Dis"},{"issue":"Suppl 1","key":"2019092716314146900_DKW202C14","first-page":"S152","article-title":"Oral antibiotic therapy","volume":"32","author":"O'Toole","year":"2014","journal-title":"J Orthop Res"},{"key":"2019092716314146900_DKW202C15","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/cid\/cir842","article-title":"Systemic antibiotic therapy for chronic osteomyelitis in adults","volume":"54","author":"Spellberg","year":"2012","journal-title":"Clin Infect Dis"},{"key":"2019092716314146900_DKW202C16","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/jac\/dkm296","article-title":"Diffusion of ertapenem into bone and synovial tissues","volume":"60","author":"Boselli","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"2019092716314146900_DKW202C17","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1179\/joc.2003.15.2.134","article-title":"Diffusion of cefepime into cancellous and cortical bone tissue","volume":"15","author":"Breilh","year":"2003","journal-title":"J Chemother"},{"key":"2019092716314146900_DKW202C18","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.1128\/AAC.41.10.2292","article-title":"Pharmacokinetic study of cefodizime and ceftriaxone in sera and bones of patients undergoing hip arthroplasty","volume":"41","author":"Scaglione","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"2019092716314146900_DKW202C19","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1128\/AAC.38.4.905","article-title":"Penetration of piperacillin-tazobactam into cancellous and cortical bone tissues","volume":"38","author":"Incavo","year":"1994","journal-title":"Antimicrob Agents Chemother"},{"key":"2019092716314146900_DKW202C20","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1093\/jac\/dkv481","article-title":"Importance of selection and duration of antibiotic regimen in prosthetic joint infections treated with debridement and implant retention","volume":"71","author":"Tornero","year":"2016","journal-title":"J Antimicrob Chemother"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/71\/9\/2593\/30069082\/dkw202.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,28]],"date-time":"2019-09-28T02:27:01Z","timestamp":1569637621000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/71\/9\/2593\/1750485"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,7]]},"references-count":20,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,6,7]]},"published-print":{"date-parts":[[2016,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkw202","relation":{},"ISSN":["1460-2091","0305-7453"],"issn-type":[{"value":"1460-2091","type":"electronic"},{"value":"0305-7453","type":"print"}],"subject":[],"published-other":{"date-parts":[[2016,9]]},"published":{"date-parts":[[2016,6,7]]}}}