{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:25:22Z","timestamp":1782491122157,"version":"3.54.5"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"1","funder":[{"name":"Thrasher Research Fund Early Career Award","award":["9189"],"award-info":[{"award-number":["9189"]}]},{"name":"National Institute of Child Health and Human Development of the National Institutes of Health","award":["5T32HD069054"],"award-info":[{"award-number":["5T32HD069054"]}]},{"name":"Cincinnati Training Program in Pediatric Clinical and Developmental Pharmacology"},{"name":"CCHMC Cystic Fibrosis Research and Development Program Pilot & Feasibility program"},{"name":"National Heart, Lung, and Blood Institute of the National Institutes of Health","award":["NHLBI-FOA-HL 12\u2013035"],"award-info":[{"award-number":["NHLBI-FOA-HL 12\u2013035"]}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"crossref","award":["R457-CR11"],"award-info":[{"award-number":["R457-CR11"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"crossref","award":["AMIN09YO"],"award-info":[{"award-number":["AMIN09YO"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Agency for Healthcare Research and Quality Center for Education and Research on Therapeutics","award":["AHRQ CERT 1U19HS021114"],"award-info":[{"award-number":["AHRQ CERT 1U19HS021114"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Antimicrob. Chemother."],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1093\/jac\/dkw351","type":"journal-article","created":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T00:58:25Z","timestamp":1472777905000},"page":"254-260","source":"Crossref","is-referenced-by-count":20,"title":["Urinary kidney injury biomarkers and tobramycin clearance among children and young adults with cystic fibrosis: a population pharmacokinetic analysis"],"prefix":"10.1093","volume":"72","author":[{"given":"Kevin J.","family":"Downes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Clancy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Haffner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander A.","family":"Vinks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart L.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,9,1]]},"reference":[{"key":"2016121607301282000_72.1.254.1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200812-1845PP"},{"key":"2016121607301282000_72.1.254.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.02.011"},{"key":"2016121607301282000_72.1.254.3","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/167.1.173"},{"key":"2016121607301282000_72.1.254.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2006.05.004"},{"key":"2016121607301282000_72.1.254.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2009.12.002"},{"key":"2016121607301282000_72.1.254.6","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt035"},{"key":"2016121607301282000_72.1.254.7","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01314-10"},{"key":"2016121607301282000_72.1.254.8","doi-asserted-by":"publisher","DOI":"10.1592\/phco.21.5.443.34490"},{"key":"2016121607301282000_72.1.254.9","doi-asserted-by":"publisher","DOI":"10.1097\/00007691-199902000-00010"},{"key":"2016121607301282000_72.1.254.10","doi-asserted-by":"publisher","DOI":"10.1097\/MOP.0b013e328343f4dd"},{"key":"2016121607301282000_72.1.254.11","doi-asserted-by":"publisher","DOI":"10.1159\/000078452"},{"key":"2016121607301282000_72.1.254.12","doi-asserted-by":"publisher","DOI":"10.1159\/000312879"},{"key":"2016121607301282000_72.1.254.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)74811-X"},{"key":"2016121607301282000_72.1.254.14","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-007-0601-4"},{"key":"2016121607301282000_72.1.254.15","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318169245a"},{"key":"2016121607301282000_72.1.254.16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200523056"},{"key":"2016121607301282000_72.1.254.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.12.031"},{"key":"2016121607301282000_72.1.254.18","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118176"},{"key":"2016121607301282000_72.1.254.19","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.499"},{"key":"2016121607301282000_72.1.254.20","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2011.613123"},{"key":"2016121607301282000_72.1.254.21","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1681\/ASN.V104685","article-title":"Evidence for an essential role of megalin in transepithelial transport of retinol","volume":"10","author":"Christensen","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"2016121607301282000_72.1.254.22","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1093\/clinchem\/33.6.775","article-title":"Assessment of urinary retinol-binding protein as an index of proximal tubular injury","volume":"33","author":"Bernard","year":"1987","journal-title":"Clin Chem"},{"key":"2016121607301282000_72.1.254.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.12.024"},{"key":"2016121607301282000_72.1.254.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2005.09.003"},{"key":"2016121607301282000_72.1.254.25","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm260"},{"key":"2016121607301282000_72.1.254.26","doi-asserted-by":"publisher","DOI":"10.1177\/0192623310362244"},{"key":"2016121607301282000_72.1.254.27","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.96"},{"key":"2016121607301282000_72.1.254.28","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfq202"},{"key":"2016121607301282000_72.1.254.29","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp070"},{"key":"2016121607301282000_72.1.254.30","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22795"},{"key":"2016121607301282000_72.1.254.31","doi-asserted-by":"crossref","first-page":"128","DOI":"10.7150\/ijbs.5.128","article-title":"Assay validation for KIM-1: human urinary renal dysfunction biomarker","volume":"5","author":"Chaturvedi","year":"2009","journal-title":"Int J Biol Sci"},{"key":"2016121607301282000_72.1.254.32","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008030287"},{"key":"2016121607301282000_72.1.254.33","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"2016121607301282000_72.1.254.34","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010121302"},{"key":"2016121607301282000_72.1.254.35","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-012-2180-x"},{"key":"2016121607301282000_72.1.254.36","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04010907"},{"key":"2016121607301282000_72.1.254.37","doi-asserted-by":"publisher","DOI":"10.1016\/0010-4825(92)90011-B"},{"key":"2016121607301282000_72.1.254.38","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.3.1010-1016.2003"},{"key":"2016121607301282000_72.1.254.39","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200342050-00007"},{"key":"2016121607301282000_72.1.254.40","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.310.6980.633"},{"key":"2016121607301282000_72.1.254.41","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-013-9348-7"},{"key":"2016121607301282000_72.1.254.42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.03045.x"},{"key":"2016121607301282000_72.1.254.43","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-013-0036-y"},{"key":"2016121607301282000_72.1.254.44","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1754.2006.00944.x"},{"key":"2016121607301282000_72.1.254.45","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00539-13"},{"key":"2016121607301282000_72.1.254.46","doi-asserted-by":"publisher","DOI":"10.2310\/JIM.0b013e31829cbd14"},{"key":"2016121607301282000_72.1.254.47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.11.051"},{"key":"2016121607301282000_72.1.254.48","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1128\/AAC.43.5.1003","article-title":"Aminoglycosides: nephrotoxicity","volume":"43","author":"Mingeot-Leclercq","year":"1999","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/72\/1\/254\/8496911\/dkw351.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T15:10:42Z","timestamp":1657206642000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article-lookup\/doi\/10.1093\/jac\/dkw351"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,1]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,16]]},"published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1093\/jac\/dkw351"],"URL":"https:\/\/doi.org\/10.1093\/jac\/dkw351","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,9,1]]}}}