{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T12:55:01Z","timestamp":1760014501968,"version":"3.37.3"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","funder":[{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Antimicrob. Chemother."],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1093\/jac\/dkw354","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T00:08:05Z","timestamp":1474416485000},"page":"172-180","source":"Crossref","is-referenced-by-count":8,"title":["Impact of bacterial load on pharmacodynamics and susceptibility breakpoints for tigecycline and<i>Klebsiella pneumoniae<\/i>"],"prefix":"10.1093","volume":"72","author":[{"given":"Marilena","family":"Tsala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sophia","family":"Vourli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George L.","family":"Daikos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanassios","family":"Tsakris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loukia","family":"Zerva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan W.","family":"Mouton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Meletiadis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,9,19]]},"reference":[{"key":"2016121607301282000_72.1.172.1","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.13.71"},{"key":"2016121607301282000_72.1.172.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2015.06.011"},{"key":"2016121607301282000_72.1.172.3","doi-asserted-by":"publisher","DOI":"10.1007\/s002030050339"},{"key":"2016121607301282000_72.1.172.4","doi-asserted-by":"publisher","DOI":"10.1592\/phco.26.8.1099"},{"key":"2016121607301282000_72.1.172.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.12.004"},{"key":"2016121607301282000_72.1.172.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.11.009"},{"key":"2016121607301282000_72.1.172.7","doi-asserted-by":"publisher","DOI":"10.1186\/cc13858"},{"key":"2016121607301282000_72.1.172.8","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00662-11"},{"key":"2016121607301282000_72.1.172.9","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000214"},{"key":"2016121607301282000_72.1.172.10","doi-asserted-by":"publisher","DOI":"10.1086\/431674"},{"key":"2016121607301282000_72.1.172.11","unstructured":"EUCAST. Tigecycline. Rationale for the EUCAST Clinical Breakpoints, Version 1.0, 2006 . http:\/\/www.eucast.org\/fileadmin\/src\/media\/PDFs\/EUCAST_files\/Rationale_documents\/Tigecyclinerationale1.0.pdf ."},{"key":"2016121607301282000_72.1.172.12","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl403"},{"key":"2016121607301282000_72.1.172.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2005.02.013"},{"key":"2016121607301282000_72.1.172.14","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp301"},{"key":"2016121607301282000_72.1.172.15","doi-asserted-by":"crossref","unstructured":"Pitkin DH , Marin-Mazuelos E . Bioassay methods for antimicrobial and antifungal agents. In: Schwalbe R , Steele-Moore L , Goodwin AC , eds. Antimicrobial Susceptibility Testing Protocols . 10th edn. Boca Raton, FL: CRC Press, 2007; 313.","DOI":"10.1201\/9781420014495.ch14"},{"key":"2016121607301282000_72.1.172.16","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01051-10"},{"key":"2016121607301282000_72.1.172.17","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00277-10"},{"key":"2016121607301282000_72.1.172.18","doi-asserted-by":"publisher","DOI":"10.1186\/1476-0711-12-24"},{"key":"2016121607301282000_72.1.172.19","doi-asserted-by":"publisher","DOI":"10.1086\/648720"},{"key":"2016121607301282000_72.1.172.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2009.02.009"},{"key":"2016121607301282000_72.1.172.21","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1128\/CMR.10.3.444","article-title":"Update on detection of bacteremia and fungemia","volume":"10","author":"Reimer","year":"1997","journal-title":"Clin Microbiol Rev"},{"key":"2016121607301282000_72.1.172.22","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1128\/JCM.17.5.864-869.1983","article-title":"Microbiological and clinical evaluation of the Isolator lysis-centrifugation blood culture tube","volume":"17","author":"Henry","year":"1983","journal-title":"J Clin Microbiol"},{"key":"2016121607301282000_72.1.172.23","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.3.3.269"},{"key":"2016121607301282000_72.1.172.24","doi-asserted-by":"crossref","unstructured":"Dan JM , Mendler MH , Hemming AW et al . High-dose tigecycline and colistin for successful treatment of disseminated carbapenem-resistant Klebsiella pneumoniae infection in a liver transplant recipient. BMJ Case Rep 2014; 2014.","DOI":"10.1136\/bcr-2014-205865"},{"key":"2016121607301282000_72.1.172.25","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.51.6963"},{"key":"2016121607301282000_72.1.172.26","doi-asserted-by":"publisher","DOI":"10.1136\/thx.54.10.867"},{"key":"2016121607301282000_72.1.172.27","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.2.8306025"},{"key":"2016121607301282000_72.1.172.28","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis588"},{"key":"2016121607301282000_72.1.172.29","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01084-06"},{"key":"2016121607301282000_72.1.172.30","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00813-07"},{"key":"2016121607301282000_72.1.172.31","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2011.022"},{"key":"2016121607301282000_72.1.172.32","first-page":"498","article-title":"Penetration, efflux and intracellular activity of tigecycline in human polymorphonuclear neutrophils (PMNs)","volume":"56","author":"Ong","year":"2005","journal-title":"J Chemother"},{"key":"2016121607301282000_72.1.172.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.09.008"},{"key":"2016121607301282000_72.1.172.34","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01253-10"},{"key":"2016121607301282000_72.1.172.35","first-page":"220","article-title":"Protection of Enterococcus faecalis in mixed cultures with carbapenemase-producing Escherichia coli and Bacteroides fragilis: effect of the bacterial load","volume":"26","author":"Sevillano","year":"2013","journal-title":"Rev Esp Quimioter"},{"key":"2016121607301282000_72.1.172.36","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01678-08"},{"key":"2016121607301282000_72.1.172.37","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.10.012"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/72\/1\/172\/8496985\/dkw354.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,26]],"date-time":"2020-09-26T04:49:04Z","timestamp":1601095744000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article-lookup\/doi\/10.1093\/jac\/dkw354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,19]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,12,16]]},"published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1093\/jac\/dkw354"],"URL":"https:\/\/doi.org\/10.1093\/jac\/dkw354","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"type":"print","value":"0305-7453"},{"type":"electronic","value":"1460-2091"}],"subject":[],"published":{"date-parts":[[2016,9,19]]}}}