{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T00:40:10Z","timestamp":1782261610557,"version":"3.54.5"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"name":"Novartis Medical School"},{"name":"Spanish Network for Research in Infectious Diseases","award":["REIPI RD06\/0008"],"award-info":[{"award-number":["REIPI RD06\/0008"]}]},{"name":"Hospital Clinic, Barcelona (Spain)"},{"name":"\u2018Rio Hortega\u2019 Research","award":["CM14\/00135"],"award-info":[{"award-number":["CM14\/00135"]}]},{"name":"Instituto de Salud Carlos III and the Ministerio de Economia and Competitividad, Madrid (Spain)","award":["INT15\/00168"],"award-info":[{"award-number":["INT15\/00168"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"DOI":"10.1093\/jac\/dkx016","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T13:23:51Z","timestamp":1485782631000},"page":"1714-1722","source":"Crossref","is-referenced-by-count":19,"title":["Early in vitro development of daptomycin non-susceptibility in high-level aminoglycoside-resistant Enterococcus faecalis predicts the efficacy of the combination of high-dose daptomycin plus ampicillin in an in vivo model of experimental endocarditis"],"prefix":"10.1093","volume":"72","author":[{"given":"J. M.","family":"Peric\u00e0s","sequence":"first","affiliation":[{"name":"Infectious Diseases Service, Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Pi i Sunyer (IDIBAPS), University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Garc\u00eda-de-la-M\u00e0ria","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Pi i Sunyer (IDIBAPS), University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Brunet","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Unit, Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Pi i Sunyer (IDIBAPS), University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Armero","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Pi i Sunyer (IDIBAPS), University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Garc\u00eda-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Pi i Sunyer (IDIBAPS), University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Casals","sequence":"additional","affiliation":[{"name":"Pharmacology and Toxicology Unit, Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Pi i Sunyer (IDIBAPS), University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Almela","sequence":"additional","affiliation":[{"name":"Microbiology Service, Center Diagnostic Biomedical (CDB), Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Pi i Sunyer (IDIBAPS), University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Quintana","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Service, Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Pi i Sunyer (IDIBAPS), University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Falces","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Pi i Sunyer (IDIBAPS), University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Ninot","sequence":"additional","affiliation":[{"name":"Cardiac Surgery Service, Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Pi i Sunyer (IDIBAPS), University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Fuster","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Pi i Sunyer (IDIBAPS), University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Llopis","sequence":"additional","affiliation":[{"name":"Department of Statistics, Faculty of Biology, University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Marco","sequence":"additional","affiliation":[{"name":"Microbiology Service, Center Diagnostic Biomedical (CDB), Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Pi i Sunyer (IDIBAPS), University of Barcelona, Spain"},{"name":"ISGlobal, Barcelona Ctr. Int, Health Res. (CRESIB), Hospital Clinic of Barcelona, University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Moreno","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Pi i Sunyer (IDIBAPS), University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Mir\u00f3","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Hospital Clinic of Barcelona, Institut d\u2019Investigacions Biom\u00e8diques Pi i Sunyer (IDIBAPS), University of Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Hospital Clinic Endocarditis Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,2,14]]},"reference":[{"key":"key\n\t\t\t\t20180328135228_dkx016-B1","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.2217\/fmb.15.46","article-title":"Enterococcal endocarditis revisited","volume":"10","author":"Peric\u00e1s","year":"2015","journal-title":"Future Microbiol"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B2","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1111\/1469-0691.12166","article-title":"Enterococcal endocarditis in the beginning of the 21st century: analysis from the International Collaboration on Endocarditis\u2014Prospective Cohort Study","volume":"19","author":"Chirouze","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B3","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1161\/CIR.0000000000000296","article-title":"Infective endocarditis in adults: diagnosis, antimicrobial therapy, and management of complications: a scientific statement for healthcare professionals from the American Heart Association","volume":"132","author":"Baddour","year":"2015","journal-title":"Circulation"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B4","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1093\/eurheartj\/ehv319","article-title":"2015 ESC Guidelines for the management of infective endocarditis: The Task Force for the Management of Infective Endocarditis of the European Society of Cardiology (ESC). Endorsed by: European Association for Cardio-Thoracic Surgery (EACTS), the European Association of Nuclear Medicine (EANM)","volume":"36","author":"Habib","year":"2015","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ijantimicag.2010.11.038","article-title":"Clinical utility of daptomycin in infective endocarditis caused by Gram-positive cocci","volume":"38","author":"Cervera","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B6","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ijantimicag.2014.01.018","article-title":"Daptomycin activity tested against 164457 bacterial isolates from hospitalised patients: summary of 8 years of a Worldwide Surveillance Programme (2005-2012)","volume":"43","author":"Sader","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/cid\/ciq113","article-title":"Daptomycin nonsusceptible enterococci: an emerging challenge for clinicians","volume":"52","author":"Kelesidis","year":"2011","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B8","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1128\/CMR.00030-13","article-title":"A current perspective on daptomycin for the clinical microbiologist","volume":"26","author":"Humphries","year":"2013","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B9","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1128\/AAC.06439-11","article-title":"Evaluation of standard- and high-dose daptomycin versus linezolid against vancomycin-resistant Enterococcus isolates in an in vitro pharmacokinetic\/pharmacodynamic model with simulated endocardial vegetations","volume":"56","author":"Hall","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B10","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1345\/aph.1M085","article-title":"Safety and clinical outcomes when utilizing high-dose (\u2265\u20098\u2009mg\/kg) daptomycin therapy","volume":"43","author":"Moise","year":"2009","journal-title":"Ann Pharmacother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B11","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1592\/phco.31.6.527","article-title":"High-dose daptomycin for treatment of complicated gram-positive infections: a large, multicenter, retrospective study","volume":"31","author":"Kullar","year":"2011","journal-title":"Pharmacotherapy"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B12","doi-asserted-by":"crossref","first-page":"6213","DOI":"10.1128\/AAC.01563-13","article-title":"High-dose daptomycin therapy for left-sided infective endocarditis: a prospective study from the International Collaboration on Endocarditis","volume":"57","author":"Carugati","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B13","doi-asserted-by":"crossref","first-page":"6064","DOI":"10.1128\/AAC.01760-12","article-title":"Combination therapy with ampicillin and daptomycin for treatment of Enterococcus faecalis endocarditis","volume":"56","author":"Sierra-Hoffman","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B14","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1093\/cid\/civ449","article-title":"Linezolid vs daptomycin for vancomycin-resistant enterococci: the evidence gap between trials and clinical experience","volume":"61","author":"McKinnell","year":"2015","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B15","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jac\/dku386","article-title":"Ceftobiprole and ampicillin increase daptomycin susceptibility of daptomycin-susceptible and -resistant VRE","volume":"70","author":"Werth","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B16","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1128\/AAC.00053-15","article-title":"\u03b2-Lactams enhance daptomycin activity against vancomycin-resistant Enterococcus faecalis and Enterococcus faecium in in vitro pharmacokinetic\/pharmacodynamic models","volume":"59","author":"Smith","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B17","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1093\/jac\/dkv007","article-title":"\u03b2-Lactam combinations with daptomycin provide synergy against vancomycin-resistant Enterococcus faecalis and Enterococcus faecium","volume":"70","author":"Smith","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B18","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.1128\/AAC.05077-14","article-title":"In vitro activity of daptomycin in combination with \u03b2-lactams, gentamicin, rifampin, and tigecycline against daptomycin-nonsusceptible enterococci","volume":"59","author":"Hindler","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B19","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1128\/AAC.02481-12","article-title":"Treatment of high-level gentamicin-resistant Enterococcus faecalis endocarditis with daptomycin plus ceftaroline","volume":"57","author":"Sakoulas","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B20","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1128\/AAC.02274-13","article-title":"Ceftaroline restores daptomycin activity against daptomycin-nonsusceptible vancomycin-resistant Enterococcus faecium","volume":"58","author":"Sakoulas","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B21","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing: Twenty-first Informational Supplement M100-S21","author":"Clinical Laboratory Standards Institute","year":"2011"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B22","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1128\/AAC.01921-12","article-title":"Early in vitro and in vivo development of high-level daptomycin resistance is common in mitis group streptococci after exposure to daptomycin","volume":"57","author":"Garc\u00eda-de-la-M\u00e0ria","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B23","first-page":"330","volume-title":"Antibiotics in Laboratory Medicine","author":"Eliopoulos","year":"1996","edition":"4th edn"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B24","first-page":"231","volume-title":"Antibiotics in Laboratory Medicine","author":"Edberg","year":"1996","edition":"4th edn"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B25","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1128\/AAC.02139-15","article-title":"Fosfomycin plus \u03b2-lactams as synergistic bactericidal combinations for experimental endocarditis due to methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus","volume":"60","author":"Del Rio","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B26","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1128\/AAC.00510-07","article-title":"Daptomycin is effective in treatment of experimental endocarditis due to methicillin-resistant and glycopeptide-intermediate Staphylococcus aureus","volume":"52","author":"Marco","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B27","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1023\/A:1007669411738","article-title":"Bioanalytical method validation\u2014a revisit with a decade of progress","volume":"17","author":"Shah","year":"2000","journal-title":"Pharm Res"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B28","first-page":"394","article-title":"Experimental endocarditis. I. Staphylococcal endocarditis in rabbits resulting from placement of a polyethylene catheter in the right side of the heart","volume":"42","author":"Garrison","year":"1970","journal-title":"Yale J Biol Med"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B29","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1128\/AAC.01266-06","article-title":"Efficacy of telavancin in the treatment of experimental endocarditis due to glycopeptide-intermediate Staphylococcus aureus","volume":"51","author":"Miro","year":"2007","journal-title":"Antimicrob. Agents Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B30","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1128\/AAC.00207-11","article-title":"Genetic basis for daptomycin resistance in Enterococci","volume":"55","author":"Palmer","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B31","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1056\/NEJMoa1011138","article-title":"Genetic basis for in vivo daptomycin resistance in enterococci","volume":"365","author":"Arias","year":"2011","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B32","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.ijantimicag.2009.12.022","article-title":"In vitro prevention of the emergence of daptomycin resistance in Staphylococcus aureus and Enterococci following combination with amoxicillin\/clavulanic acid or ampicillin","volume":"35","author":"Entenza","year":"2010","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B33","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1128\/AAC.43.3.639","article-title":"Efficacy of ampicillin plus ceftriaxone in treatment of experimental endocarditis due to Enterococcus faecalis strains highly resistant to aminoglycosides","volume":"43","author":"Gavald\u00e0","year":"1999","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B34","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1093\/jac\/dkl406","article-title":"Efficacy of daptomycin in the treatment of experimental endocarditis due to susceptible and multidrug-resistant enterococci","volume":"58","author":"Vouillamoz","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B35","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1128\/AAC.36.9.1864","article-title":"Comparison of daptomycin, vancomycin, and ampicillin-gentamicin for treatment of experimental endocarditis caused by penicillin-resistant enterococci","volume":"36","author":"Ramos","year":"1992","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0732-8893(92)90045-U","article-title":"In vivo activity of the combination of daptomycin and fosfomycin compared with daptomycin alone against a strain of Enterococcus faecalis with high-level gentamicin resistance in the rat endocarditis model","volume":"15","author":"Rice","year":"1992","journal-title":"Diagn Microbiol Infect Dis"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B37","volume-title":"Enterococci: From Commensals to Leading Causes of Drug Resistant Infection","author":"Kristich","year":"2014"},{"key":"key\n\t\t\t\t20180328135228_dkx016-B38","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1128\/AAC.40.1.173","article-title":"Treatment of experimental endocarditis due to Enterococcus faecalis using once-daily dosing regimen of gentamicin plus simulated profiles of ampicillin in human serum","volume":"40","author":"Gavald\u00e0","year":"1996","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/72\/6\/1714\/17234782\/dkx016.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T01:01:41Z","timestamp":1658538101000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/72\/6\/1714\/2996231"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,14]]},"references-count":38,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,2,14]]},"published-print":{"date-parts":[[2017,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkx016","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,6]]},"published":{"date-parts":[[2017,2,14]]}}}