{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:44:04Z","timestamp":1787996644359,"version":"build-2784847793"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Toyama Chemical Co., Ltd"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,6,1]]},"DOI":"10.1093\/jac\/dkx020","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T13:23:51Z","timestamp":1485782631000},"page":"1709-1713","source":"Crossref","is-referenced-by-count":50,"title":["In vitro and in vivo antifungal activities of T-2307, a novel arylamidine, against Cryptococcus gattii: an emerging fungal pathogen"],"prefix":"10.1093","volume":"72","author":[{"given":"Hiroshi","family":"Nishikawa","sequence":"first","affiliation":[{"name":"Research Laboratories, Toyama Chemical Co., Ltd, 2-4-1 Shimookui, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Research Laboratories, Toyama Chemical Co., Ltd, 2-4-1 Shimookui, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Mitsuyama","sequence":"additional","affiliation":[{"name":"Research Laboratories, Toyama Chemical Co., Ltd, 2-4-1 Shimookui, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Tashiro","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akitaka","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Infection Control and Education Center, Nagasaki University Hospital, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Takazono","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Saijo","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Infection Control and Education Center, Nagasaki University Hospital, Nagasaki, Japan"},{"name":"Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Imamura","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiga","family":"Miyazaki","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"},{"name":"Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kakeya","sequence":"additional","affiliation":[{"name":"Department of Infection Control Science, Graduate School of Medicine, Osaka City University, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Infectious Diseases, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsunori","family":"Yanagihara","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Mukae","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan"},{"name":"Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kohno","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Nagasaki University Hospital, Nagasaki, Japan"},{"name":"Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Izumikawa","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,2,13]]},"reference":[{"key":"key\n\t\t\t\t20180313122721_dkx020-B1","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1086\/649858","article-title":"Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America","volume":"50","author":"Perfect","year":"2010","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B2","doi-asserted-by":"crossref","first-page":"840452.","DOI":"10.1155\/2009\/840452","article-title":"Cryptococcus gattii: an emerging cause of fungal disease in North America","volume":"2009","author":"Dixit","year":"2009","journal-title":"Interdiscip Perspect Infect Dis"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1080\/mmy.39.2.155.168","article-title":"Cryptococcus neoformans variety gattii","volume":"39","author":"Sorrell","year":"2001","journal-title":"Med Mycol"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B4","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1128\/AAC.01159-07","article-title":"In vitro and in vivo antifungal activities of T-2307, a novel arylamidine","volume":"52","author":"Mitsuyama","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B5","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1128\/JCM.15.3.535-537.1982","article-title":"Improved diagnostic medium for separation of Cryptococcus neoformans var. neoformans (serotypes A and D) and Cryptococcus neoformans var. gattii (serotypes B and C)","volume":"15","author":"Kwon-Chung","year":"1982","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3201\/eid0902.020246","article-title":"Molecular typing of IberoAmerican Cryptococcus neoformans isolates","volume":"9","author":"Meyer","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B7","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1080\/13693780902953886","article-title":"Consensus multi-locus sequence typing scheme for Cryptococcus neoformans and Cryptococcus gattii","volume":"47","author":"Meyer","year":"2009","journal-title":"Med Mycol"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B8","author":"Clinical and Laboratory Standards Institute","year":"2008"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B9","author":"Clinical and Laboratory Standards Institute","year":"2008"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B10","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1128\/CMR.17.2.268-280.2004","article-title":"Determination of fungicidal activities against yeasts and molds: lessons learned from bacterial testing and the need for standardization","volume":"17","author":"Pfaller","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B11","doi-asserted-by":"crossref","first-page":"5892","DOI":"10.1128\/AAC.05954-11","article-title":"T-2307 causes collapse of mitochondrial membrane potential in yeast","volume":"56","author":"Shibata","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1056\/NEJM199201093260202","article-title":"Comparison of amphotericin B with fluconazole in the treatment of acute AIDS-associated cryptococcal meningitis. The NIAID Mycoses Study Group and the AIDS Clinical Trials Group","volume":"326","author":"Saag","year":"1992","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/clinids\/20.2.263","article-title":"Amphotericin B as primary therapy for cryptococcosis in patients with AIDS: reliability of relatively high doses administered over a relatively short period","volume":"20","author":"de Lalla","year":"1995","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B14","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1056\/NEJM199707033370103","article-title":"Treatment of cryptococcal meningitis associated with the acquired immunodeficiency syndrome","volume":"337","author":"van der Horst","year":"1997","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B15","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/jac\/dkh055","article-title":"Comparative studies on the efficacy of AmBisome and Fungizone in a mouse model of disseminated aspergillosis","volume":"53","author":"Takemoto","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ijpharm.2011.01.044","article-title":"Characterization of the colloidal properties, in vitro antifungal activity, antileishmanial activity and toxicity in mice of a di-stigma-steryl-hemi-succinoyl-glycero-phosphocholine liposome-intercalated amphotericin B","volume":"408","author":"Iman","year":"2011","journal-title":"Int J Pharm"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B17","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1128\/AAC.00296-07","article-title":"Correlation of the MIC and dose\/MIC ratio of fluconazole to the therapeutic response of patients with mucosal candidiasis and candidemia","volume":"51","author":"Rodriguez-Tudela","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.ejps.2016.05.022","article-title":"Pharmacokinetics\/pharmacodynamic correlations of fluconazole in murine model of cryptococcosis","volume":"92","author":"Santos","year":"2016","journal-title":"Eur J Pharm Sci"},{"key":"key\n\t\t\t\t20180313122721_dkx020-B19","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1111\/tmi.12067","article-title":"The impact of routine cryptococcal antigen screening on survival among HIV-infected individuals with advanced immunosuppression in Kenya","volume":"18","author":"Meyer","year":"2013","journal-title":"Trop Med Int Health"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/72\/6\/1709\/24331981\/dkx020.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T04:46:33Z","timestamp":1601527593000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/72\/6\/1709\/2993120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,13]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,2,13]]},"published-print":{"date-parts":[[2017,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkx020","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,6]]},"published":{"date-parts":[[2017,2,13]]}}}