{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:24:03Z","timestamp":1787009043202,"version":"build-2736575974"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"7","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AI111990"],"award-info":[{"award-number":["R01AI111990"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institute of Allergy and Infectious Diseases of the National Institutes of Health"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"DOI":"10.1093\/jac\/dkx070","type":"journal-article","created":{"date-parts":[[2017,4,20]],"date-time":"2017-04-20T15:08:22Z","timestamp":1492700902000},"page":"1985-1990","source":"Crossref","is-referenced-by-count":41,"title":["Pharmacodynamics of colistin and fosfomycin: a \u2018treasure trove\u2019 combination combats KPC-producing Klebsiella pneumoniae"],"prefix":"10.1093","volume":"72","author":[{"given":"Miao","family":"Zhao","sequence":"first","affiliation":[{"name":"Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA"},{"name":"Institute of Antibiotics, Huashan Hospital, Fudan University & Key Laboratory of Clinical Pharmacology of Antibiotics, National Health and Family Planning Commission, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zackery P.","family":"Bulman","sequence":"additional","affiliation":[{"name":"Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin R.","family":"Lenhard","sequence":"additional","affiliation":[{"name":"Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Satlin","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, Cornell University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry N.","family":"Kreiswirth","sequence":"additional","affiliation":[{"name":"Public Health Research Institute, Newark, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine, Cornell University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Marrocco","sequence":"additional","affiliation":[{"name":"Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip J.","family":"Bergen","sequence":"additional","affiliation":[{"name":"Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Nation","sequence":"additional","affiliation":[{"name":"Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Li","sequence":"additional","affiliation":[{"name":"Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Antibiotics, Huashan Hospital, Fudan University & Key Laboratory of Clinical Pharmacology of Antibiotics, National Health and Family Planning Commission, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Laboratory for Antimicrobial Pharmacodynamics, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, Buffalo, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,4,21]]},"reference":[{"key":"key\n\t\t\t\t20180313122719_dkx070-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/595011","article-title":"Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America","volume":"48","author":"Boucher","year":"2009","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/1469-0691.12427","article-title":"ESCMID guidelines for the management of the infection control measures to reduce transmission of multidrug-resistant Gram-negative bacteria in hospitalized patients","volume":"20","author":"Tacconelli","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B3","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/SMJ.0b013e3181fd7d5a","article-title":"Emergence of Klebsiella pneumoniae carbapenemase-producing bacteria","volume":"104","author":"Arnold","year":"2011","journal-title":"South Med J"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B4","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S1473-3099(06)70580-1","article-title":"Colistin: the re-emerging antibiotic for multidrug-resistant Gram-negative bacterial infections","volume":"6","author":"Li","year":"2006","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B5","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1093\/jac\/dkv086","article-title":"Infections caused by KPC-producing Klebsiella pneumoniae: differences in therapy and mortality in a multicentre study","volume":"70","author":"Tumbarello","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B6","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1093\/cid\/cis588","article-title":"Predictors of mortality in bloodstream infections caused by Klebsiella pneumoniae carbapenemase-producing K. pneumoniae: importance of combination therapy","volume":"55","author":"Tumbarello","year":"2012","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.ijantimicag.2014.02.016","article-title":"Colistin resistance in Klebsiella pneumoniae","volume":"44","author":"Ah","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B8","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1473-3099(15)00424-7","article-title":"Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study","volume":"16","author":"Liu","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B9","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.jiac.2016.01.010","article-title":"Fosfomycin: resurgence of an old companion","volume":"22","author":"Sastry","year":"2016","journal-title":"J Infect Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B10","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ijantimicag.2009.10.019","article-title":"Antimicrobial susceptibility of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Enterobacteriaceae isolates to fosfomycin","volume":"35","author":"Falagas","year":"2010","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B11","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1128\/AAC.01235-09","article-title":"In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and\/or colistin","volume":"54","author":"Endimiani","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B12","doi-asserted-by":"crossref","first-page":"5744","DOI":"10.1128\/AAC.00402-12","article-title":"Experience with fosfomycin for treatment of urinary tract infections due to multidrug-resistant organisms","volume":"56","author":"Neuner","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B13","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1093\/jac\/dks270","article-title":"Emergence of resistance to fosfomycin used as adjunct therapy in KPC Klebsiella pneumoniae bacteraemia: report of three cases","volume":"67","author":"Karageorgopoulos","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B14","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.cbi.2004.05.005","article-title":"Protective effect of fosfomycin on gentamicin-induced lipid peroxidation of rat renal tissue","volume":"148","author":"Yanagida","year":"2004","journal-title":"Chem Biol Interact"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B15","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1211\/0022357991772187","article-title":"Effects of fosfomycin and imipenem-cilastatin on the nephrotoxicity of vancomycin and cisplatin in rats","volume":"51","author":"Nakamura","year":"1999","journal-title":"J Pharm Pharmacol"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B16","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1128\/AAC.02435-13","article-title":"Preliminary study of colistin versus colistin plus fosfomycin for treatment of carbapenem-resistant Acinetobacter baumannii infections","volume":"58","author":"Sirijatuphat","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B17","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ijantimicag.2013.09.010","article-title":"Outcomes of critically ill intensive care unit patients treated with fosfomycin for infections due to pandrug-resistant and extensively drug-resistant carbapenemase-producing Gram-negative bacteria","volume":"43","author":"Pontikis","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B18","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1469-0691.2009.02921.x","article-title":"Intravenous fosfomycin for the treatment of nosocomial infections caused by carbapenem-resistant Klebsiella pneumoniae in critically ill patients: a prospective evaluation","volume":"16","author":"Michalopoulos","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B19","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1128\/AAC.01086-10","article-title":"In vitro interactions of antimicrobial combinations with fosfomycin against KPC-2-producing Klebsiella pneumoniae and protection of resistance development","volume":"55","author":"Souli","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B20","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.diagmicrobio.2013.04.004","article-title":"In vitro activity of fosfomycin in combination with imipenem, meropenem, colistin and tigecycline against OXA 48-positive Klebsiella pneumoniae strains","volume":"76","author":"Evren","year":"2013","journal-title":"Diagn Microbiol Infect Dis"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B21","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1128\/AAC.01477-06","article-title":"Systematic comparison of the population pharmacokinetics and pharmacodynamics of piperacillin in cystic fibrosis patients and healthy volunteers","volume":"51","author":"Bulitta","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B22","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1128\/AAC.04508-14","article-title":"Evolution of Staphylococcus aureus under vancomycin selective pressure: the role of the small-colony variant phenotype","volume":"59","author":"Lenhard","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B23","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/jac\/42.2.227","article-title":"Bacterial concentrations in pus and infected peritoneal fluid\u2014implications for bactericidal activity of antibiotics","volume":"42","author":"K\u00f6nig","year":"1998","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B24","doi-asserted-by":"crossref","first-page":"788.e1","DOI":"10.1016\/j.cmi.2015.05.004","article-title":"Development of two real-time multiplex PCR assays for the detection and quantification of eight key bacterial pathogens in lower respiratory tract infections","volume":"21","author":"Gadsby","year":"2015","journal-title":"Clin Microbiol Infect"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B25","first-page":"56","article-title":"Asymptomatic infections of the urinary tract","volume":"69","author":"Kass","year":"1956","journal-title":"Trans Assoc Am Physicians"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B26","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/jac\/dkg187","article-title":"Target site penetration of fosfomycin in critically ill patients","volume":"51","author":"Joukhadar","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B27","first-page":"171","article-title":"Pharmacokinetic aspects of cerebrospinal fluid penetration of fosfomycin","volume":"5","author":"Pfeifer","year":"1985","journal-title":"Int J Clin Pharmacol Res"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B28","doi-asserted-by":"crossref","first-page":"4448","DOI":"10.1128\/AAC.49.11.4448-4454.2005","article-title":"Antibiotic abscess penetration: fosfomycin levels measured in pus and simulated concentration-time profiles","volume":"49","author":"Sauermann","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B29","volume-title":"Abstracts of the Fifty-first Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago, IL, USA, 2011","author":"Garonzik"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B30","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1093\/jac\/dku567","article-title":"Colistin and doripenem combinations against Pseudomonas aeruginosa: profiling the time course of synergistic killing and prevention of resistance","volume":"70","author":"Ly","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B31","volume-title":"Abstracts of the Fifty-fifth Interscience Conference on Antimicrobial Agents and Chemotherapy, San Diego, CA, USA, 2015","author":"Zhao"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B32","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1128\/AAC.44.10.2728-2732.2000","article-title":"Distribution and antimicrobial activity of fosfomycin in the interstitial fluid of human soft tissues","volume":"44","author":"Frossard","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B33","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/jac\/15.suppl_A.125","article-title":"In-vitro model for simultaneous simulation of the serum kinetics of two drugs with different half-lives","volume":"15","author":"Blaser","year":"1985","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B34","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/ja.2014.73","article-title":"LC-MS\/MS determination of colistin in Mueller-Hinton broth for in vitro pharmacodynamic studies","volume":"67","author":"Zhao","year":"2014","journal-title":"J Antibiot"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B35","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1093\/cid\/civ048","article-title":"Colistin-resistant Acinetobacter baumannii: beyond carbapenem resistance","volume":"60","author":"Qureshi","year":"2015","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B36","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.mib.2010.09.002","article-title":"Polymyxins and their novel derivatives","volume":"13","author":"Vaara","year":"2010","journal-title":"Curr Opin Microbiol"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B37","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ab.2010.10.033","article-title":"Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions","volume":"409","author":"Soon","year":"2011","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B38","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ijantimicag.2010.09.002","article-title":"Adverse events associated with intravenous fosfomycin","volume":"37","author":"Florent","year":"2011","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B39","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ijantimicag.2013.05.018","article-title":"What is the relevance of fosfomycin pharmacokinetics in the treatment of serious infections in critically ill patients? A systematic review","volume":"42","author":"Parker","year":"2013","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B40","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1128\/AAC.01733-10","article-title":"Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients","volume":"55","author":"Garonzik","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B41","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.1128\/AAC.01361-08","article-title":"Population pharmacokinetic analysis of colistin methanesulfonate and colistin after intravenous administration in critically ill patients with infections caused by gram-negative bacteria","volume":"53","author":"Plachouras","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122719_dkx070-B42","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.clinthera.2008.01.015","article-title":"Colistin serum concentrations after intravenous administration in critically ill patients with serious multidrug-resistant, gram-negative bacilli infections: a prospective, open-label, uncontrolled study","volume":"30","author":"Markou","year":"2008","journal-title":"Clin Ther"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/72\/7\/1985\/24332219\/dkx070.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,13]],"date-time":"2018-03-13T12:33:19Z","timestamp":1520944399000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/72\/7\/1985\/3748240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,21]]},"references-count":42,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,4,21]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkx070","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2017,4,21]]}}}