{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T17:44:21Z","timestamp":1762623861463,"version":"3.37.3"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"7","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD064354","K23AI080842","UM1 AI068634","UM1 AI068636","UM1 AI106701","U01 AI068632","AI068632"],"award-info":[{"award-number":["R01HD064354","K23AI080842","UM1 AI068634","UM1 AI068636","UM1 AI106701","U01 AI068632","AI068632"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"DOI":"10.1093\/jac\/dkx112","type":"journal-article","created":{"date-parts":[[2017,3,21]],"date-time":"2017-03-21T08:30:07Z","timestamp":1490085007000},"page":"2028-2034","source":"Crossref","is-referenced-by-count":8,"title":["Prevention of TB using rifampicin plus isoniazid reduces nevirapine concentrations in HIV-exposed infants"],"prefix":"10.1093","volume":"72","author":[{"given":"Helen","family":"McIlleron","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Denti","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Cohn","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Center for Tuberculosis Research, School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fildah","family":"Mashabela","sequence":"additional","affiliation":[{"name":"Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV\/AIDS and TB, University of the Witwatersrand, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer D.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Center for Tuberculosis Research, School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saba","family":"Shembe","sequence":"additional","affiliation":[{"name":"Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV\/AIDS and TB, University of the Witwatersrand, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Msandiwa","sequence":"additional","affiliation":[{"name":"Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV\/AIDS and TB, University of the Witwatersrand, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lubbe","family":"Wiesner","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Cape Town, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sithembiso","family":"Velaphi","sequence":"additional","affiliation":[{"name":"Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV\/AIDS and TB, University of the Witwatersrand, South Africa"},{"name":"Department of Paediatrics and Child Health, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjay G.","family":"Lala","sequence":"additional","affiliation":[{"name":"Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV\/AIDS and TB, University of the Witwatersrand, South Africa"},{"name":"Department of Paediatrics and Child Health, Chris Hani Baragwanath Academic Hospital, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E.","family":"Chaisson","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Center for Tuberculosis Research, School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Martinson","sequence":"additional","affiliation":[{"name":"Perinatal HIV Research Unit (PHRU), MRC Soweto Matlosana Collaborating Center for HIV\/AIDS and TB, University of the Witwatersrand, South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly E.","family":"Dooley","sequence":"additional","affiliation":[{"name":"Johns Hopkins University Center for Tuberculosis Research, School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the Tshepiso Study Team","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,4,16]]},"reference":[{"year":"2016","author":"South African National AIDS Council","key":"key\n\t\t\t\t20180328140933_dkx112-B1"},{"year":"2010","author":"WHO","key":"key\n\t\t\t\t20180328140933_dkx112-B2"},{"author":"Department of Health, Republic of South Africa","key":"key\n\t\t\t\t20180328140933_dkx112-B3"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B4","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/QAI.0b013e3181900201","article-title":"Intensified case finding for tuberculosis in prevention of mother-to-child transmission programs: a simple and potentially vital addition for maternal and child health","volume":"50","author":"Deluca","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B5","doi-asserted-by":"crossref","first-page":"e77","DOI":"10.1097\/QAI.0b013e31821ac9c1","article-title":"Active tuberculosis case-finding among pregnant women presenting to antenatal clinics in Soweto, South Africa","volume":"57","author":"Gounder","year":"2011","journal-title":"J Acquir Immune Defic Syndr"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B6","doi-asserted-by":"crossref","first-page":"e62211.","DOI":"10.1371\/journal.pone.0062211","article-title":"High prevalence of pulmonary tuberculosis but low sensitivity of symptom screening among HIV-infected pregnant women in South Africa","volume":"8","author":"Hoffmann","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B7","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1086\/520983","article-title":"The effectiveness of a 9-month regimen of isoniazid alone versus 3- and 4-month regimens of isoniazid plus rifampin for treatment of latent tuberculosis infection in children: results of an 11-year randomized study","volume":"45","author":"Spyridis","year":"2007","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B8","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1183\/13993003.01245-2015","article-title":"Management of latent Mycobacterium tuberculosis infection: WHO guidelines for low tuberculosis burden countries","volume":"46","author":"Getahun","year":"2015","journal-title":"Eur Respir J"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B9","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1080\/20469047.2016.1200288","article-title":"Characteristics of infants exposed to maternal tuberculosis and chemoprophylaxis using 3\u2009months of isoniazid and rifampicin","volume":"37","author":"Mathivha","year":"2017","journal-title":"Paediatr Int Child Health"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B10","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1093\/infdis\/jit223","article-title":"Clinical and genetic determinants of plasma nevirapine exposure following an intrapartum dose to prevent mother-to-child HIV transmission","volume":"208","author":"Vardhanabhuti","year":"2013","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B11","doi-asserted-by":"crossref","first-page":"891","DOI":"10.2217\/pgs-2015-0016","article-title":"Pharmacogenetics of nevirapine excretion into breast milk and infants' exposure through breast milk versus postexposure prophylaxis","volume":"17","author":"Olagunju","year":"2016","journal-title":"Pharmacogenomics"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/jac\/dkw388","article-title":"Effect of diurnal variation, CYP2B6 genotype and age on the pharmacokinetics of nevirapine in African children","volume":"72","author":"Bienczak","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/jac\/dkn441","article-title":"Persistence of nevirapine in breast milk and plasma of mothers and their children after single-dose administration","volume":"63","author":"Kunz","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B14","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/jac\/dkm484","article-title":"Effect of rifampicin-based antitubercular therapy on nevirapine plasma concentrations in South African adults with HIV-associated tuberculosis","volume":"61","author":"Cohen","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B15","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1097\/QAD.0b013e3283550e20","article-title":"Pharmacokinetics of nevirapine in HIV-infected children under 3 years on rifampicin-based antituberculosis treatment","volume":"26","author":"Oudijk","year":"2012","journal-title":"AIDS"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B16","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1128\/AAC.02051-15","article-title":"Population pharmacokinetics of rifampin in pregnant women with tuberculosis and HIV coinfection in Soweto, South Africa","volume":"60","author":"Denti","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/infdis\/jiu429","article-title":"Pharmacokinetics of efavirenz and treatment of HIV-1 among pregnant women with and without tuberculosis coinfection","volume":"211","author":"Dooley","year":"2015","journal-title":"J Infect Dis"},{"volume-title":"NONMEM User\u2019s Guides (1989-2009)","year":"2009","author":"Beal","key":"key\n\t\t\t\t20180328140933_dkx112-B18"},{"author":"Karlsson","key":"key\n\t\t\t\t20180328140933_dkx112-B19"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B20","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s10928-007-9066-0","article-title":"Implementation of a transit compartment model for describing drug absorption in pharmacokinetic studies","volume":"34","author":"Savic","year":"2007","journal-title":"J Pharmacokinet Pharmacodyn"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B21","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.pharmtox.48.113006.094708","article-title":"Mechanism-based concepts of size and maturity in pharmacokinetics","volume":"48","author":"Anderson","year":"2008","journal-title":"Annu Rev Pharmacol Toxicol"},{"year":"2010","author":"WHO","key":"key\n\t\t\t\t20180328140933_dkx112-B22"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00126334-200306010-00006","article-title":"Predose infant nevirapine concentration with the two-dose intrapartum neonatal nevirapine regimen: association with timing of maternal intrapartum nevirapine dose","volume":"33","author":"Mirochnick","year":"2003","journal-title":"J Acquir Immune Defic Syndr"},{"author":"Department of Health and Human Services","key":"key\n\t\t\t\t20180328140933_dkx112-B24"},{"year":"2015","author":"WHO","key":"key\n\t\t\t\t20180328140933_dkx112-B25"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B26","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0140-6736(99)80008-7","article-title":"Intrapartum and neonatal single-dose nevirapine compared with zidovudine for prevention of mother-to-child transmission of HIV-1 in Kampala, Uganda: HIVNET 012 randomised trial","volume":"354","author":"Guay","year":"1999","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B27","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1001\/jama.282.8.744","article-title":"HIV transmission through breastfeeding: a study in Malawi","volume":"282","author":"Miotti","year":"1999","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B28","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/cid\/cis808","article-title":"Pooled individual data analysis of 5 randomized trials of infant nevirapine prophylaxis to prevent breast-milk HIV-1 transmission","volume":"56","author":"Hudgens","year":"2013","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B29","first-page":"21","article-title":"Maternal triple antiretrovirals (MART) and infant nevirapine (iNVP) prophylaxis for the prevention of mother-to-child transmission (MTCT) of HIV during breastfeeding (BF)","volume":"7","author":"Taha","year":"2016","journal-title":"Rev Antiviral Ther Infect Dis"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B30","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/QAI.0b013e31802b920e","article-title":"Selection and persistence of viral resistance in HIV-infected children after exposure to single-dose nevirapine","volume":"44","author":"Martinson","year":"2007","journal-title":"J Acquir Immune Defic Syndr"},{"key":"key\n\t\t\t\t20180328140933_dkx112-B31","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1097\/QAD.0000000000000814","article-title":"Frequent nevirapine resistance in infants infected by HIV-1 via breastfeeding while on nevirapine prophylaxis","volume":"29","author":"Nelson","year":"2015","journal-title":"AIDS"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/72\/7\/2028\/24332490\/dkx112.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T15:50:32Z","timestamp":1522252232000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/72\/7\/2028\/3737542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,16]]},"references-count":31,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,4,16]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkx112","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"type":"print","value":"0305-7453"},{"type":"electronic","value":"1460-2091"}],"subject":[],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2017,4,16]]}}}