{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:48:52Z","timestamp":1790516932538,"version":"4.1.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,8,1]]},"DOI":"10.1093\/jac\/dkx117","type":"journal-article","created":{"date-parts":[[2017,4,12]],"date-time":"2017-04-12T11:08:33Z","timestamp":1491995313000},"page":"2263-2272","source":"Crossref","is-referenced-by-count":33,"title":["The quinoline bromoquinol exhibits broad-spectrum antifungal activity and induces oxidative stress and apoptosis in Aspergillus fumigatus"],"prefix":"10.1093","volume":"72","author":[{"given":"Dafna","family":"Ben Yaakov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Shadkchan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathaniel","family":"Albert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios P.","family":"Kontoyiannis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Osherov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,5]]},"reference":[{"key":"key\n\t\t\t\t20171012105721_dkx117-B1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1097\/QCO.0b013e32832db9f3","article-title":"Invasive mould infections in the setting of hematopoietic cell transplantation: current trends and new challenges","volume":"22","year":"2009","journal-title":"Curr Opin Infect Dis"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B2","first-page":"95","article-title":"Epidemiology and risk factors for invasive candidiasis","volume":"10","year":"2014","journal-title":"Ther Clin Risk Manag"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B3","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/myc.12081","article-title":"Epidemiology and sites of involvement of invasive fungal infections in patients with haematological malignancies: a 20-year autopsy study","volume":"56","year":"2013","journal-title":"Mycoses"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B4","first-page":"165rv13.","article-title":"Hidden killers: human fungal infections","volume":"4","year":"2012","journal-title":"Sci Transl Med"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B5","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0140-6736(00)82003-6","article-title":"Early diagnosis of invasive aspergillosis","volume":"355","year":"2000","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0163-4453(96)92700-0","article-title":"Trends in the postmortem epidemiology of invasive fungal infections at a university hospital","volume":"33","year":"1996","journal-title":"J Infect"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B7","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1097\/QCO.0b013e32835ebcb7","article-title":"New antifungal antibiotics","volume":"26","year":"2013","journal-title":"Curr Opin Infect Dis"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B8","first-page":"28.","article-title":"Iron\u2014a key nexus in the virulence of Aspergillus fumigatus","volume":"3","year":"2012","journal-title":"Front Microbiol"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B9","doi-asserted-by":"crossref","first-page":"e1003034.","DOI":"10.1371\/journal.ppat.1003034","article-title":"Zinc exploitation by pathogenic fungi","volume":"8","year":"2012","journal-title":"PLoS Pathog"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1080\/21505594.2015.1109766","article-title":"Mutant characterization and in vivo conditional repression identify aromatic amino acid biosynthesis to be essential for Aspergillus fumigatus virulence","volume":"7","year":"2016","journal-title":"Virulence"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B11","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1046\/j.1365-2958.2000.01953.x","article-title":"Signature-tagged and directed mutagenesis identify PABA synthetase as essential for Aspergillus fumigatus pathogenicity","volume":"36","year":"2000","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B12","doi-asserted-by":"crossref","first-page":"22044","DOI":"10.1073\/pnas.1009845107","article-title":"Pathway analysis of Candida albicans survival and virulence determinants in a murine infection model","volume":"107","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/BF02053368","article-title":"The effects of specific auxotrophic mutations on the virulence of Aspergillus nidulans for mice","volume":"50","year":"1973","journal-title":"Mycopathol Mycol Appl"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B14","doi-asserted-by":"crossref","first-page":"5631","DOI":"10.1128\/AAC.00850-15","article-title":"Identification and characterization of a novel family of selective antifungal compounds (CANBEFs) that interfere with fungal protein synthesis","volume":"59","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B15","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi\u2013Second Edition: Approved Standard M38\u2010A2","author":"Clinical and Laboratory Standards Institute","year":"2008"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B16","volume-title":"Reference Method for Broth Dilution Antifungal Testing of Yeasts\u2013Third Edition: Approved Standard M27-A3","author":"Clinical and Laboratory Standards Institute","year":"2008"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00294-003-0480-6","article-title":"Disruption of the Aspergillus fumigatus argB gene using a novel in vitro transposon-based mutagenesis approach","volume":"45","year":"2004","journal-title":"Curr Genet"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1006\/fgbi.2000.1236","article-title":"Polarity-defective mutants of Aspergillus nidulans","volume":"31","year":"2000","journal-title":"Fungal Genet Biol"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B19","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/genetics\/155.2.647","article-title":"Conidial germination in Aspergillus nidulans requires RAS signaling and protein synthesis","volume":"155","year":"2000","journal-title":"Genetics"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B20","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1128\/IAI.00011-16","article-title":"Identification and characterization of a novel Aspergillus fumigatus rhomboid family putative protease, RbdA, involved in hypoxia sensing and virulence","volume":"84","year":"2016","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B21","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1083\/jcb.104.6.1495","article-title":"Regulation of the mRNA levels of nimA, a gene required for the G2-M transition in Aspergillus nidulans","volume":"104","year":"1987","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B22","doi-asserted-by":"crossref","first-page":"8234","DOI":"10.1128\/AEM.01808-12","article-title":"Breaking the silence: protein stabilization uncovers silenced biosynthetic gene clusters in the fungus Aspergillus nidulans","volume":"78","year":"2012","journal-title":"Appl Environ Microbiol"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B23","first-page":"1157","article-title":"8-Hydroxyquinolines: a review of their metal chelating properties and medicinal applications","volume":"7","year":"2013","journal-title":"Drug Des Devel Ther"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B24","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1017\/S0953756298008235","article-title":"Fungitoxicity of oxine and copper oxinate: activity spectrum, development of resistance and synergy","volume":"103","year":"1999","journal-title":"Mycol Res"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B25","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.1755-5949.2010.00231.x","article-title":"Clioquinol: review of its mechanisms of action and clinical uses in neurodegenerative disorders","volume":"18","year":"2012","journal-title":"CNS Neurosci Ther"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.ijantimicag.2016.04.019","article-title":"In vitro antifungal and antibiofilm activities of halogenated quinoline analogues against Candida albicans and Cryptococcus neoformans","volume":"48","year":"2016","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B27","doi-asserted-by":"crossref","first-page":"e0136932","DOI":"10.1371\/journal.pone.0136932","article-title":"Network modeling reveals cross talk of MAP kinases during adaptation to caspofungin stress in Aspergillus fumigatus","volume":"10","year":"2015","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B28","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00294-006-0073-2","article-title":"Transcriptome analysis of Aspergillus fumigatus exposed to voriconazole","volume":"50","year":"2006","journal-title":"Curr Genet"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B29","doi-asserted-by":"crossref","first-page":"4220","DOI":"10.1128\/AAC.01431-07","article-title":"Proteomic and transcriptomic analysis of Aspergillus fumigatus on exposure to amphotericin B","volume":"52","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B30","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s11046-014-9779-8","article-title":"Large-scale transcriptional response to hypoxia in Aspergillus fumigatus observed using RNAseq identifies a novel hypoxia regulated ncRNA","volume":"178","year":"2014","journal-title":"Mycopathologia"},{"key":"key\n\t\t\t\t20171012105721_dkx117-B31","doi-asserted-by":"crossref","first-page":"e1002374","DOI":"10.1371\/journal.pgen.1002374","article-title":"SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus","volume":"7","year":"2011","journal-title":"PLoS Genet"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/72\/8\/2263\/18801236\/dkx117.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T15:00:52Z","timestamp":1719154852000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/jac\/article\/72\/8\/2263\/3798703\/The-quinoline-bromoquinol-exhibits-broadspectrum"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,5]]},"references-count":31,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2017,5,5]]},"published-print":{"date-parts":[[2017,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkx117","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,8]]},"published":{"date-parts":[[2017,5,5]]}}}