{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:01:36Z","timestamp":1790805696118,"version":"4.1.0"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"suppl_2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,9,1]]},"DOI":"10.1093\/jac\/dkx311","type":"journal-article","created":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T08:11:24Z","timestamp":1503562284000},"page":"i3-i19","source":"Crossref","is-referenced-by-count":87,"title":["Meta-analyses and the evidence base for microbial outcomes in the treatment of pulmonary Mycobacterium avium\u2013intracellulare complex disease"],"prefix":"10.1093","volume":"72","author":[{"given":"Jotam G.","family":"Pasipanodya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Ogbonna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devyani","family":"Deshpande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashikant","family":"Srivastava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawanda","family":"Gumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,9,11]]},"reference":[{"key":"key\n\t\t\t\t20171011214957_dkx311-B1","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1164\/rccm.201002-0310OC","article-title":"Nontuberculous mycobacterial lung disease prevalence at four integrated health care delivery systems","volume":"182","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B2","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1164\/rccm.200604-571ST","article-title":"An official ATS\/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases","volume":"175","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B3","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1164\/rccm.201003-0503OC","article-title":"Pulmonary nontuberculous mycobacterial disease prevalence and clinical features: an emerging public health disease","volume":"182","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B4","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1093\/cid\/ciw484","article-title":"Partnerships to design novel regimens to treat childhood tuberculosis, sui generis: the road ahead","volume":"63","year":"2016","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B5","doi-asserted-by":"crossref","first-page":"582","DOI":"10.5588\/ijtld.15.0807","article-title":"Mortality among patients with pulmonary non-tuberculous mycobacteria disease","volume":"20","year":"2016","journal-title":"Int J Tuberc Lung Dis"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B6","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1378\/chest.126.2.566","article-title":"Mycobacterium avium complex pulmonary disease in patients without HIV infection","volume":"126","year":"2004","journal-title":"Chest"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B7","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10096-013-1962-1","article-title":"Treatment outcomes for Mycobacterium avium complex: a systematic review and meta-analysis","volume":"33","year":"2014","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B8","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1016\/j.rmed.2011.08.004","article-title":"Impaired health-related quality of life in pulmonary nontuberculous mycobacterial disease","volume":"105","year":"2011","journal-title":"Respir Med"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B9","doi-asserted-by":"crossref","first-page":"829","DOI":"10.5588\/ijtld.12.0672","article-title":"High-resolution computed tomography and health-related quality of life in Mycobacterium avium complex disease","volume":"17","year":"2013","journal-title":"Int J Tuberc Lung Dis"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B10","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.rmed.2006.04.002","article-title":"A double-blind randomized study of aminoglycoside infusion with combined therapy for pulmonary Mycobacterium avium complex disease","volume":"101","year":"2007","journal-title":"Respir Med"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B11","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1159\/000095674","article-title":"The microbiological and clinical effects of combined therapy according to guidelines on the treatment of pulmonary Mycobacterium avium complex disease in Japan\u2014including a follow-up study","volume":"74","year":"2007","journal-title":"Respiration"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B12","first-page":"e123","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"3","year":"2009","journal-title":"Open Med"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B13","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2217\/fmb.11.25","article-title":"Pharmacokinetic\/pharmacodynamic-based treatment of disseminated Mycobacterium avium","volume":"6","year":"2011","journal-title":"Future Microbiol"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B14","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1093\/clinids\/23.5.983","article-title":"Azithromycin activity against Mycobacterium avium complex lung disease in patients who were not infected with human immunodeficiency virus","volume":"23","year":"1996","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B15","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1164\/rccm.201503-0444OC","article-title":"Semiquantitative culture analysis during therapy for Mycobacterium avium complex lung disease","volume":"192","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jclinepi.2011.05.008","article-title":"Development of the RTI item bank on risk of bias and precision of observational studies","volume":"65","year":"2012","journal-title":"J Clin Epidemiol"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B17","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/j.jclinepi.2014.11.023","article-title":"Grading the strength of a body of evidence when assessing health care interventions: an EPC update","volume":"68","year":"2015","journal-title":"J Clin Epidemiol"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/2049-3258-72-39","article-title":"Metaprop: a Stata command to perform meta-analysis of binomial data","volume":"72","year":"2014","journal-title":"Arch Public Health"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B19","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1002\/sim.1752","article-title":"Controlling the risk of spurious findings from meta-regression","volume":"23","year":"2004","journal-title":"Stat Med"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B20","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1001\/jama.282.11.1054","article-title":"The hazards of scoring the quality of clinical trials for meta-analysis","volume":"282","year":"1999","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B21","first-page":"438","article-title":"A four-drug regimen for initial treatment of cavitary disease caused by Mycobacterium avium complex","volume":"134","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1136\/thorax.56.3.167","article-title":"First randomised trial treatments for pulmonary disease caused by M. avium intracellulare, M. malmoense, and M. xenopi in HIV negative patients: rifampicin, ethambutol and isoniazid versus rifampicin and ethambutol","volume":"56","author":"Research Committee of the British Thoracic Society","year":"2001","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B23","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1164\/ajrccm.149.5.8173775","article-title":"Initial clarithromycin monotherapy for Mycobacterium avium-intracellulare complex lung disease","volume":"149","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B24","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1378\/chest.107.4.1035","article-title":"Clarithromycin in the treatment of Mycobacterium avium lung infections in patients without AIDS. Clarithromycin Study Group of France","volume":"107","year":"1995","journal-title":"Chest"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B25","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1164\/ajrccm.153.6.8665032","article-title":"Clarithromycin regimens for pulmonary Mycobacterium avium complex. The first 50 patients","volume":"153","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B26","first-page":"462","article-title":"Clarithromycin with minocycline and clofazimine for Mycobacterium avium intracellulare complex lung disease in patients without the acquired immune deficiency syndrome. GETIM. Groupe d'Etude et de Traitement des Infections a Mycobacteries","volume":"2","year":"1998","journal-title":"Int J Tuberc Lung Dis"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B27","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1086\/515597","article-title":"Initial (6-month) results of three-times-weekly azithromycin in treatment regimens for Mycobacterium avium complex lung disease in human immunodeficiency virus-negative patients","volume":"178","year":"1998","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B28","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1164\/ajrccm.160.3.9811086","article-title":"Effect of clarithromycin regimen for Mycobacterium avium complex pulmonary disease","volume":"160","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B29","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1086\/313644","article-title":"Early results (at 6\u2009months) with intermittent clarithromycin-including regimens for lung disease due to Mycobacterium avium complex","volume":"30","year":"2000","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B30","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1086\/320512","article-title":"Azithromycin-containing regimens for treatment of Mycobacterium avium complex lung disease","volume":"32","year":"2001","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B31","doi-asserted-by":"crossref","first-page":"670","DOI":"10.2169\/internalmedicine.42.670","article-title":"The effect of combined therapy according to the guidelines for the treatment of Mycobacterium avium complex pulmonary disease","volume":"42","year":"2003","journal-title":"Intern Med"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B32","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1164\/rccm.200509-1531OC","article-title":"Factors related to response to intermittent treatment of Mycobacterium avium complex lung disease","volume":"173","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B33","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1136\/thx.2007.087999","article-title":"Clarithromycin vs ciprofloxacin as adjuncts to rifampicin and ethambutol in treating opportunist mycobacterial lung diseases and an assessment of Mycobacterium vaccae immunotherapy","volume":"63","year":"2008","journal-title":"Thorax"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B34","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1378\/chest.12-0494","article-title":"Clinical significance of the differentiation between Mycobacterium avium and Mycobacterium intracellulare in M. avium complex lung disease","volume":"142","year":"2012","journal-title":"Chest"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B35","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1513\/AnnalsATS.201308-266OC","article-title":"Efficacy of clarithromycin and ethambutol for Mycobacterium avium complex pulmonary disease. A preliminary study","volume":"11","year":"2014","journal-title":"Ann Am Thorac Soc"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B36","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1378\/chest.13-2538","article-title":"Macrolide\/azalide therapy for nodular\/bronchiectatic Mycobacterium avium complex lung disease","volume":"146","year":"2014","journal-title":"Chest"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B37","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1164\/rccm.201408-1545OC","article-title":"Intermittent antibiotic therapy for nodular bronchiectatic Mycobacterium avium complex lung disease","volume":"191","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B38","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1378\/chest.15-0543","article-title":"Long-term follow-up of Mycobacterium avium complex lung disease in patients treated with regimens including clofazimine and\/or rifampin","volume":"149","year":"2016","journal-title":"Chest"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B39","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1513\/AnnalsATS.201305-136OC","article-title":"Opinions differ by expertise in Mycobacterium avium complex disease","volume":"11","year":"2014","journal-title":"Ann Am Thorac Soc"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B40","doi-asserted-by":"crossref","first-page":"4806","DOI":"10.1128\/AAC.05546-11","article-title":"The antibiotic-resistance arrow of time: efflux pump induction is a general first step in the evolution of mycobacterial drug-resistance","volume":"56","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B41","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1128\/AAC.02854-15","article-title":"Azithromycin dose to maximize efficacy and suppress acquired drug resistance in pulmonary Mycobacterium avium disease","volume":"60","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B42","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1128\/AAC.01355-09","article-title":"Ethambutol optimal clinical dose and susceptibility breakpoint identification by use of a novel pharmacokinetic-pharmacodynamic model of disseminated intracellular Mycobacterium avium","volume":"54","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B43","doi-asserted-by":"crossref","first-page":"ii20","DOI":"10.1093\/jac\/dkx303","article-title":"Failure of the azithromycin and ethambutol combination regimen in the hollow-fibre system model of pulmonary Mycobacterium avium infection is due to acquired resistance","volume":"72","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B44","doi-asserted-by":"crossref","first-page":"ii48","DOI":"10.1093\/jac\/dkx307","article-title":"A novel ceftazidime\/avibactam, rifabutin, tedizolid and moxifloxacin (CARTM) regimen for pulmonary Mycobacterium avium disease","volume":"72","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B45","doi-asserted-by":"crossref","first-page":"ii43","DOI":"10.1093\/jac\/dkx308","article-title":"A \u2018shock and awe\u2019 thioridazine and moxifloxacin combination-based regimen for pulmonary Mycobacterium avium\u2013intracellulare complex disease","volume":"72","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B46","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.1462-5822.2005.00667.x","article-title":"The ability to form biofilm influences Mycobacterium avium invasion and translocation of bronchial epithelial cells","volume":"8","year":"2006","journal-title":"Cell Microbiol"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B47","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/cid\/cis353","article-title":"Meta-analysis of clinical studies supports the pharmacokinetic variability hypothesis for acquired drug resistance and failure of antituberculosis therapy","volume":"55","year":"2012","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B48","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1128\/AAC.01567-09","article-title":"Clinical and toxicodynamic evidence that high-dose pyrazinamide is not more hepatotoxic than the low doses currently used","volume":"54","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B49","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/cid\/cit167","article-title":"A meta-analysis of self-administered vs directly observed therapy effect on microbiologic failure, relapse, and acquired drug resistance in tuberculosis patients","volume":"57","year":"2013","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B50","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1128\/AAC.01761-09","article-title":"Moxifloxacin pharmacokinetics\/pharmacodynamics and optimal dose and susceptibility breakpoint identification for treatment of disseminated Mycobacterium avium infection","volume":"54","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B51","doi-asserted-by":"crossref","first-page":"ii24","DOI":"10.1093\/jac\/dkx304","article-title":"Linezolid as treatment for pulmonary Mycobacterium avium disease","volume":"72","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B52","doi-asserted-by":"crossref","first-page":"ii30","DOI":"10.1093\/jac\/dkx305","article-title":"Tedizolid is highly bactericidal in the treatment of pulmonary Mycobacterium avium complex disease","volume":"72","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B53","first-page":"628","article-title":"Pulmonary disease caused by Mycobacterium avium-intracellulare in HIV-negative patients: five-year follow-up of patients receiving standardised treatment","volume":"6","author":"The Research Committee of the British Thoracic Society","year":"2002","journal-title":"Int J Tuberc Lung Dis"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B54","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3349\/ymj.2010.51.6.888","article-title":"Standardized combination antibiotic treatment of Mycobacterium avium complex lung disease","volume":"51","year":"2010","journal-title":"Yonsei Med J"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B55","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1164\/rccm.201206-1088OC","article-title":"Therapeutic drug monitoring in the treatment of Mycobacterium avium complex lung disease","volume":"186","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"key\n\t\t\t\t20171011214957_dkx311-B56","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1378\/chest.124.4.1482","article-title":"Treatment of Mycobacterium avium-intracellulare complex lung disease with a macrolide, ethambutol, and clofazimine","volume":"124","year":"2003","journal-title":"Chest"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/72\/suppl_2\/i3\/19733569\/dkx311.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,2]],"date-time":"2019-10-02T15:15:21Z","timestamp":1570029321000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/jac\/article\/72\/suppl_2\/i3\/4110810\/Metaanalyses-and-the-evidence-base-for-microbial"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,1]]},"references-count":56,"journal-issue":{"issue":"suppl_2","published-online":{"date-parts":[[2017,9,11]]},"published-print":{"date-parts":[[2017,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkx311","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,9]]},"published":{"date-parts":[[2017,9,1]]}}}