{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:27:27Z","timestamp":1769023647768,"version":"3.49.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"DOI":"10.1093\/jac\/dkx394","type":"journal-article","created":{"date-parts":[[2017,9,30]],"date-time":"2017-09-30T19:08:00Z","timestamp":1506798480000},"page":"452-455","source":"Crossref","is-referenced-by-count":22,"title":["Polymyxin derivatives NAB739 and NAB815 are more effective than polymyxin B in murine Escherichia coli pyelonephritis"],"prefix":"10.1093","volume":"73","author":[{"given":"Martti","family":"Vaara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timo","family":"Vaara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carina","family":"Vingsbo Lundberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,11,14]]},"reference":[{"key":"key\n\t\t\t\t20180123023229_dkx394-B1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s10096-011-1424-6","article-title":"Impact of healthcare-associated acquisition on community-onset Gram-negative bloodstream infection: a population-based study: healthcare-associated Gram-negative BSI","volume":"31","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jinf.2010.12.009","article-title":"Epidemiology, microbiology and outcomes of healthcare-associated and community-acquired bacteremia: a multicenter cohort study","volume":"62","year":"2011","journal-title":"J Infect"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B3","first-page":"1","year":"2015"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B4","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/phar.1493","article-title":"Adverse reactions associated with systemic polymyxin therapy","volume":"35","year":"2015","journal-title":"Pharmacotherapy"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B5","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1517\/14740338.2015.1088520","article-title":"The safety of polymyxin antibiotics","volume":"14","year":"2015","journal-title":"Expert Opin Drug Saf"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B6","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1128\/AAC.01733-10","article-title":"Population pharmacokinetics of colistin methanesulfonate and formed colistin in critically ill patients from a multicenter study provide dosing suggestions for various categories of patients","volume":"55","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B7","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/ja.2016.146","article-title":"Development of new polymyxin derivatives for multi-drug resistant Gram-negative infections","volume":"70","year":"2017","journal-title":"J Antibiot"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B8","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/med.21321","article-title":"Lipopeptides from Bacillus and Paenibacillus spp.: a gold mine of antibiotic candidates","volume":"36","year":"2016","journal-title":"Med Res Rev"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B9","first-page":"258","article-title":"Lipopeptides as anti-infectives: a practical perspective","volume":"4","year":"2009","journal-title":"Cent Eur J Biol"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B10","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/jac\/dkt039","article-title":"Novel derivatives of polymyxins","volume":"68","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B11","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.4155\/fmc-2016-0091","article-title":"Polymyxins: a new hope in combating Gram-negative superbugs","volume":"8","year":"2016","journal-title":"Future Med Chem"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B12","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1128\/AAC.00405-08","article-title":"Novel polymyxin derivatives carrying only three positive charges are effective antibacterial agents","volume":"52","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B13","volume-title":"Polymyxin Derivative and Uses Thereof","year":"2016"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B14","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.peptides.2017.03.002","article-title":"Structure-activity studies on polymyxin derivatives carrying three positive charges only reveal a new class of compounds with strong antibacterial activity","volume":"91","year":"2017","journal-title":"Peptides"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B15","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1128\/AAC.44.1.156-163.2000","article-title":"Development of a long-term ascending urinary tract infection mouse model for antibiotic treatment studies","volume":"44","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B16","author":"Clinical and Laboratory Standards Institute","year":"2015"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B17","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/jac\/dkp331","article-title":"Pharmacokinetics of novel antimicrobial cationic peptides NAB7061 and NAB739 in rats following intravenous administration","volume":"64","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B18","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1086\/592577","article-title":"Pharmacokinetics of intravenous polymyxin B in critically ill patients","volume":"47","year":"2008","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B19","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1128\/CMR.00064-16","article-title":"Polymyxins: antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes","volume":"30","year":"2017","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20180123023229_dkx394-B20","article-title":"Novel plasmid-mediated colistin resistance mcr-4 gene in Salmonella and Escherichia coli, Italy 2013, Spain and Belgium, 2015 to 2016","volume":"22","year":"2017","journal-title":"Euro Surveill"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/73\/2\/452\/23610198\/dkx394.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T07:32:42Z","timestamp":1516692762000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/jac\/article\/73\/2\/452\/4629255"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,14]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,11,14]]},"published-print":{"date-parts":[[2018,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkx394","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,2]]},"published":{"date-parts":[[2017,11,14]]}}}