{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T04:18:26Z","timestamp":1773548306310,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"2","funder":[{"DOI":"10.13039\/100009275","name":"DFF","doi-asserted-by":"publisher","award":["# 11-106387"],"award-info":[{"award-number":["# 11-106387"]}],"id":[{"id":"10.13039\/100009275","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"publisher","award":["DNFR 120"],"award-info":[{"award-number":["DNFR 120"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,2,1]]},"DOI":"10.1093\/jac\/dkx395","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T11:08:14Z","timestamp":1507028894000},"page":"414-424","source":"Crossref","is-referenced-by-count":37,"title":["Expanding the potential of NAI-107 for treating serious ESKAPE pathogens: synergistic combinations against Gram-negatives and bactericidal activity against non-dividing cells"],"prefix":"10.1093","volume":"73","author":[{"given":"Cristina","family":"Brunati","sequence":"first","affiliation":[{"name":"NAICONS Srl, Viale Ortles 22\/4, 20139 Milano, Italy"},{"name":"KtedoGen Srl, Viale Ortles 22\/4, 20139 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas T","family":"Thomsen","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Copenhagen, Ole Maal\u00f8e\u2019s Vej 5, 2200 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Gaspari","sequence":"additional","affiliation":[{"name":"NAICONS Srl, Viale Ortles 22\/4, 20139 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Maffioli","sequence":"additional","affiliation":[{"name":"NAICONS Srl, Viale Ortles 22\/4, 20139 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita","family":"Sosio","sequence":"additional","affiliation":[{"name":"NAICONS Srl, Viale Ortles 22\/4, 20139 Milano, Italy"},{"name":"KtedoGen Srl, Viale Ortles 22\/4, 20139 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Jabes","sequence":"additional","affiliation":[{"name":"NAICONS Srl, Viale Ortles 22\/4, 20139 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"L\u00f8bner-Olesen","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Copenhagen, Ole Maal\u00f8e\u2019s Vej 5, 2200 Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Donadio","sequence":"additional","affiliation":[{"name":"NAICONS Srl, Viale Ortles 22\/4, 20139 Milano, Italy"},{"name":"KtedoGen Srl, Viale Ortles 22\/4, 20139 Milano, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2017,10,30]]},"reference":[{"key":"key\n\t\t\t\t20180313122844_dkx395-B1","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nature17042","article-title":"Antibacterial drug discovery in the resistance era","volume":"529","author":"Brown","year":"2016","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B2","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1001\/jama.2016.11764","article-title":"Antimicrobial resistance","volume":"316","author":"Marston","year":"2016","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B3","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/ja.2013.86","article-title":"Antibiotics in the clinical pipeline in 2013","volume":"66","author":"Butler","year":"2013","journal-title":"J Antibiot"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B4","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1086\/533452","article-title":"Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE","volume":"197","author":"Rice","year":"2009","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B5","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1086\/587893","article-title":"A population-based study of the incidence and molecular epidemiology of methicillin-resistant Staphylococcus aureus disease in San Francisco, 2004\u20132005","volume":"46","author":"Liu","year":"2008","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1039\/C2NP20085F","article-title":"Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature","volume":"30","author":"Arnison","year":"2013","journal-title":"Nat Prod Rep"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B7","author":"Jabes"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B8","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s10295-015-1703-9","article-title":"Advancing cell wall inhibitors towards clinical applications","volume":"43","author":"Maffioli","year":"2016","journal-title":"J Ind Microbiol Biotechnol"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B9","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1021\/acs.jnatprod.5b00576","article-title":"Brominated variant of the lantibiotic NAI-107 with enhanced antibacterial potency","volume":"78","author":"Cruz","year":"2015","journal-title":"J Nat Prod"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B10","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1021\/cb500878h","article-title":"Family of class I lantibiotics from actinomycetes and improvement of their antibacterial activities","volume":"10","author":"Maffioli","year":"2015","journal-title":"ACS Chem Biol"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B11","doi-asserted-by":"crossref","first-page":"12063","DOI":"10.1074\/jbc.M113.537449","article-title":"The lantibiotic NAI-107 binds to bactoprenol-bound cell wall precursors and impairs membrane functions","volume":"289","author":"M\u00fcnch","year":"2014","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B12","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1128\/AAC.04444-14","article-title":"In vivo pharmacokinetics and pharmacodynamics of the lantibiotic NAI-107 in a neutropenic murine thigh infection model","volume":"59","author":"Lepak","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B13","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1128\/AAC.01288-10","article-title":"Efficacy of the new lantibiotic NAI-107 in experimental infections induced by multidrug-resistant Gram-positive pathogens","volume":"55","author":"Jabes","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B14","doi-asserted-by":"crossref","first-page":"5427","DOI":"10.1128\/AAC.02965-15","article-title":"The lantibiotic NAI-107 efficiently rescues Drosophila melanogaster from infection with methicillin-resistant Staphylococcus aureus USA300","volume":"60","author":"Thomsen","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.ijmm.2009.10.005","article-title":"An oldie but a goodie\u2014cell wall biosynthesis as antibiotic target pathway","volume":"300","author":"Schneider","year":"2010","journal-title":"Int J Med Microbiol"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B16","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1128\/JB.186.13.4124-4133.2004","article-title":"The PmrA-regulated pmrC gene mediates phosphoethanolamine modification of lipid A and polymyxin resistance in Salmonella enterica","volume":"186","author":"Lee","year":"2004","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B17","doi-asserted-by":"crossref","first-page":"4971","DOI":"10.1128\/AAC.00834-10","article-title":"Colistin resistance in Acinetobacter baumannii is mediated by complete loss of lipopolysaccharide production","volume":"54","author":"Moffatt","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B18","doi-asserted-by":"crossref","first-page":"13002","DOI":"10.1038\/ncomms13002","article-title":"The evolution of antimicrobial peptide resistance in Pseudomonas aeruginosa is shaped by strong epistatic interactions","volume":"7","author":"Jochumsen","year":"2016","journal-title":"Nat Commun"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B19","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.ijantimicag.2015.07.017","article-title":"Lipopolysaccharide loss produces partial colistin dependence and collateral susceptibility to azithromycin, rifampicin and vancomycin in Acinetobacter baumannii","volume":"46","author":"Garc\u00eda-Quintanilla","year":"2015","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B20","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1128\/AAC.02642-13","article-title":"Activity of host antimicrobials against multidrug-resistant Acinetobacter baumannii acquiring colistin resistance through loss of lipopolysaccharide","volume":"58","author":"Garc\u00eda-Quintanilla","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B21","doi-asserted-by":"crossref","first-page":"5316","DOI":"10.1128\/AAC.00922-10","article-title":"Potent synergy and sustained activity of a vancomycin-colistin combination versus multidrug-resistant strains of Acinetobacter baumannii","volume":"54","author":"Gordon","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B22","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1128\/AAC.05870-11","article-title":"In vitro activity of telavancin in combination with colistin versus Gram negative bacterial pathogens","volume":"56","author":"Hornsey","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B23","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.ijantimicag.2013.12.010","article-title":"Colistin\/daptomycin: an unconventional antimicrobial combination synergistic in vitro against multidrug-resistant Acinetobacter baumannii","volume":"43","author":"Galani","year":"2014","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B24","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s40121-015-0093-7","article-title":"Optimizing polymyxin combinations against resistant Gram-negative bacteria","volume":"4","author":"Bergen","year":"2015","journal-title":"Infect Dis Ther"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B25","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/jac\/dkt039","article-title":"Novel derivatives of polymyxins","volume":"68","author":"Vaara","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B26","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1128\/AAC.00766-08","article-title":"Oritavancin kills stationary-phase and biofilm Staphylococcus aureus cells in vitro","volume":"53","author":"Belley","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B27","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1128\/AAC.00824-07","article-title":"Bactericidal action of daptomycin against stationary-phase and nondividing Staphylococcus aureus cells","volume":"51","author":"Mascio","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B28","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1016\/S0140-6736(97)07324-8","article-title":"Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin","volume":"350","author":"Hiramatsu","year":"1997","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B29","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature14098","article-title":"A new antibiotic kills pathogens without detectable resistance","volume":"517","author":"Ling","year":"2015","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B30","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.ijantimicag.2016.09.014","article-title":"Synergistic combinations of polymyxins","volume":"48","author":"Lenhard","year":"2016","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B31","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/jac\/dkr069","article-title":"In vitro activity of teicoplanin combined with colistin versus multidrug-resistant strains of Acinetobacter baumannii","volume":"66","author":"Wareham","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B32","doi-asserted-by":"crossref","first-page":"E7077","DOI":"10.1073\/pnas.1611173113","article-title":"Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains","volume":"113","author":"M\u00fcller","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B33","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1574-6976.2007.00094.x","article-title":"Peptidoglycan structure and architecture","volume":"32","author":"Vollmer","year":"2008","journal-title":"FEMS Microbiol Rev"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B34","doi-asserted-by":"crossref","first-page":"e00923-16.","DOI":"10.1128\/mBio.00923-16","article-title":"Peptidoglycan recycling in Gram-positive bacteria is crucial for survival in stationary phase","volume":"7","author":"Borisova","year":"2016","journal-title":"mBio"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B35","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1021\/acsinfecdis.5b00097","article-title":"Permeability barrier of Gram-negative cell envelopes and approaches to bypass it","volume":"1","author":"Zgurskaya","year":"2015","journal-title":"ACS Infect Dis"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B36","doi-asserted-by":"crossref","first-page":"aaf4268.","DOI":"10.1126\/science.aaf4268","article-title":"Mechanisms of bacterial persistence during stress and antibiotic exposure","volume":"354","author":"Harms","year":"2016","journal-title":"Science"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B37","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1021\/np400702t","article-title":"Characterization of the congeners in the lantibiotic NAI-107 complex","volume":"77","author":"Maffioli","year":"2014","journal-title":"J Nat Prod"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B38","author":"Clinical and Laboratory Standards Institute","year":"2006"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B39","author":"Clinical and Laboratory Standards Institute","year":"2006"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B40","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1128\/JCM.22.6.996-1006.1985","article-title":"Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices","volume":"22","author":"Christensen","year":"1985","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B41","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1600-0463.2007.apm_630.x","article-title":"Quantification of biofilm in microtiter plates: overview of testing conditions and practical recommendations for assessment of biofilm production by staphylococci","volume":"115","author":"Stefanovic","year":"2007","journal-title":"APMIS"},{"key":"key\n\t\t\t\t20180313122844_dkx395-B42","first-page":"365","volume-title":"Antibiotics in Laboratory Medicine","author":"Pillai","year":"2005","edition":"5th edn."},{"key":"key\n\t\t\t\t20180313122844_dkx395-B43","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/nprot.2007.521","article-title":"Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances","volume":"3","author":"Wiegand","year":"2008","journal-title":"Nat Protoc"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/73\/2\/414\/24332450\/dkx395.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,18]],"date-time":"2020-10-18T16:50:18Z","timestamp":1603039818000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/73\/2\/414\/4582311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,30]]},"references-count":43,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2017,10,30]]},"published-print":{"date-parts":[[2018,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkx395","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,2]]},"published":{"date-parts":[[2017,10,30]]}}}