{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:31:17Z","timestamp":1791419477436,"version":"4.3.3"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/501100000268","name":"BBSRC","doi-asserted-by":"publisher","award":["BB\/J014443\/1"],"award-info":[{"award-number":["BB\/J014443\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,6,1]]},"DOI":"10.1093\/jac\/dky019","type":"journal-article","created":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T07:06:56Z","timestamp":1516000016000},"page":"1452-1459","source":"Crossref","is-referenced-by-count":220,"title":["Discovery and development of new antibacterial drugs: learning from experience?"],"prefix":"10.1093","volume":"73","author":[{"given":"Nicole","family":"Jackson","sequence":"first","affiliation":[{"name":"Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lloyd","family":"Czaplewski","sequence":"additional","affiliation":[{"name":"Chemical Biology Ventures Ltd, 123 Alexander Close, Abingdon, Oxfordshire OX14 1XD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1460-473X","authenticated-orcid":false,"given":"Laura J V","family":"Piddock","sequence":"additional","affiliation":[{"name":"Antimicrobials Research Group, Institute of Microbiology and Infection, University of Birmingham, Birmingham B15 2TT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"key":"key\n\t\t\t\t20180626060812_dky019-B1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1021\/cr030100y","article-title":"Introduction: antibiotic resistance","volume":"105","author":"Walsh","year":"2005","journal-title":"Chem Rev"},{"key":"key\n\t\t\t\t20180626060812_dky019-B2","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1086\/652237","article-title":"The 10\u00d7'20 initiative: pursuing a global commitment to develop 10 new antibacterial drugs by 2020","volume":"50","author":"IDSA","year":"2010","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180626060812_dky019-B3","author":"United States Centers for Disease Control and Prevention","year":"2013"},{"key":"key\n\t\t\t\t20180626060812_dky019-B4","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1476-5381.2011.01250.x","article-title":"Novel classes of antibiotics or more of the same?","volume":"163","author":"Coates","year":"2011","journal-title":"Br J Pharmacol"},{"key":"key\n\t\t\t\t20180626060812_dky019-B5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/nrd2201","article-title":"Drugs for bad bugs: confronting the challenges of antibacterial discovery","volume":"6","author":"Payne","year":"2007","journal-title":"Nat Rev Drug Discov"},{"key":"key\n\t\t\t\t20180626060812_dky019-B6","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1038\/nrd.2016.229","article-title":"Market watch: antibacterial innovation in European SMEs","volume":"15","author":"Theuretzbacher","year":"2016","journal-title":"Nat Rev Drug Discov"},{"key":"key\n\t\t\t\t20180626060812_dky019-B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrd.2017.195","article-title":"Market watch: innovation in the preclinical antibiotic pipeline","volume":"16","author":"Theuretzbacher","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"key\n\t\t\t\t20180626060812_dky019-B8","author":"World Health Organization","year":"2017"},{"key":"key\n\t\t\t\t20180626060812_dky019-B9","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1128\/CMR.00030-10","article-title":"Challenges of antibacterial discovery","volume":"24","author":"Silver","year":"2011","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20180626060812_dky019-B10","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1128\/AAC.03774-14","article-title":"Bacterial resistance to leucyl-tRNA synthetase inhibitor GSK2251052 develops during treatment of complicated urinary tract infections","volume":"59","author":"O\u2019Dwyer","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180626060812_dky019-B11","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1021\/jm01240a021","article-title":"1,8-Naphthyridine derivatives. A new class of chemotherapeutic agents","volume":"5","author":"Lesher","year":"1962","journal-title":"J Med Chem"},{"key":"key\n\t\t\t\t20180626060812_dky019-B12","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nrmicro3380","article-title":"Molecular mechanisms of antibiotic resistance","volume":"13","author":"Blair","year":"2015","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20180626060812_dky019-B13","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1128\/AAC.02005-12","article-title":"The target of daptomycin is absent from Escherichia coli and other Gram-negative pathogens","volume":"57","author":"Randall","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180626060812_dky019-B14","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1517\/17460441.3.5.487","article-title":"Are natural products still the best source for antibacterial discovery? The bacterial entry factor","volume":"3","author":"Silver","year":"2008","journal-title":"Expert Opin Drug Discov"},{"key":"key\n\t\t\t\t20180626060812_dky019-B15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nature22308","article-title":"Predictive compound accumulation rules yield a broad-spectrum antibiotic","volume":"545","author":"Richter","year":"2017","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180626060812_dky019-B16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1021\/acsinfecdis.6b00003","article-title":"Progress against Escherichia coli with the oxazolidinone class of antibacterials: test case for a general approach to improving whole-cell Gram-negative activity","volume":"2","author":"Takrouri","year":"2016","journal-title":"ACS Infect Dis"},{"key":"key\n\t\t\t\t20180626060812_dky019-B17","doi-asserted-by":"crossref","first-page":"e00968","DOI":"10.1128\/mBio.00968-17","article-title":"Lack of AcrB efflux function confers loss of virulence on Salmonella enterica serovar Typhimurium","volume":"8","author":"Wang-Kan","year":"2017","journal-title":"mBio"},{"key":"key\n\t\t\t\t20180626060812_dky019-B18"},{"key":"key\n\t\t\t\t20180626060812_dky019-B19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10295-013-1325-z","article-title":"Importance of microbial natural products and the need to revitalize their discovery","volume":"41","author":"Demain","year":"2014","journal-title":"J Ind Microbiol Biotechnol"},{"key":"key\n\t\t\t\t20180626060812_dky019-B20","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1128\/AEM.01754-09","article-title":"Use of Ichip for high-throughput in situ cultivation of \u201cuncultivable\u201d microbial species","volume":"76","author":"Nichols","year":"2010","journal-title":"Appl Environ Microbiol"},{"key":"key\n\t\t\t\t20180626060812_dky019-B21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature14098","article-title":"A new antibiotic kills pathogens without detectable resistance","volume":"517","author":"Ling","year":"2015","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180626060812_dky019-B22","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1038\/nrmicro3496","article-title":"Discovery of microbial natural products by activation of silent biosynthetic gene clusters","volume":"13","author":"Rutledge","year":"2015","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20180626060812_dky019-B23","doi-asserted-by":"crossref","first-page":"6137","DOI":"10.1128\/AAC.00851-12","article-title":"Comparative in vitro and in vivo efficacies of human simulated doses of ceftazidime and ceftazidime-avibactam against Pseudomonas aeruginosa","volume":"56","author":"Crandon","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180626060812_dky019-B24","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/nrmicro.2017.121","article-title":"Understanding resistance","volume":"15","author":"Piddock","year":"2017","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20180626060812_dky019-B25","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1146\/annurev-micro-090816-093813","article-title":"Evolutionary trajectories to antibiotic resistance","volume":"8","author":"Hughes","year":"2017","journal-title":"Annu Rev Microbiol"},{"key":"key\n\t\t\t\t20180626060812_dky019-B26","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1128\/AAC.40.10.2380","article-title":"Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals","volume":"10","author":"Everett","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180626060812_dky019-B27","doi-asserted-by":"crossref","first-page":"493.","DOI":"10.1007\/s11908-015-0493-6","article-title":"Empiric antimicrobial therapy in severe sepsis and septic shock: optimizing pathogen clearance","volume":"17","author":"Liang","year":"2015","journal-title":"Curr Infect Dis Rep"},{"key":"key\n\t\t\t\t20180626060812_dky019-B28","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nrd4675","article-title":"Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?","volume":"14","author":"Brown","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"key\n\t\t\t\t20180626060812_dky019-B29","doi-asserted-by":"crossref","first-page":"e01551-14.","DOI":"10.1128\/mBio.01551-14","article-title":"LpxC inhibitors as new antibacterial agents and tools for studying regulation of lipid A biosynthesis in Gram-negative pathogens","volume":"5","author":"Tomaras","year":"2014","journal-title":"mBio"},{"key":"key\n\t\t\t\t20180626060812_dky019-B30","author":"CO-ADD"},{"key":"key\n\t\t\t\t20180626060812_dky019-B31","author":"CARB-X"},{"key":"key\n\t\t\t\t20180626060812_dky019-B32","author":"Global Antibiotic Research & Development Partnership"},{"key":"key\n\t\t\t\t20180626060812_dky019-B33","author":"University of Birmingham"},{"key":"key\n\t\t\t\t20180626060812_dky019-B34","author":"Medical Research Council"},{"key":"key\n\t\t\t\t20180626060812_dky019-B35","author":"Uppsala Universitet"},{"key":"key\n\t\t\t\t20180626060812_dky019-B36","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1038\/nrmicro.2017.75","article-title":"Prediction of antibiotic resistance: time for a new paradigm?","volume":"15","author":"Sommer","year":"2017","journal-title":"Nat Rev Microbiol"},{"key":"key\n\t\t\t\t20180626060812_dky019-B37","doi-asserted-by":"crossref","first-page":"16083.","DOI":"10.1038\/nmicrobiol.2016.83","article-title":"Roadmap for antibiotic discovery","volume":"1","author":"Shore","year":"2016","journal-title":"Nat Microbiol"},{"key":"key\n\t\t\t\t20180626060812_dky019-B38","author":"AntibioticDB"},{"key":"key\n\t\t\t\t20180626060812_dky019-B39","author":"Theuretzbacher","year":"2014"},{"key":"key\n\t\t\t\t20180626060812_dky019-B40","author":"The Pew Charitable Trusts"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/73\/6\/1452\/25087961\/dky019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T06:40:43Z","timestamp":1570603243000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/73\/6\/1452\/4847822"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,9]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,2,9]]},"published-print":{"date-parts":[[2018,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dky019","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,6]]},"published":{"date-parts":[[2018,2,9]]}}}