{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T10:15:19Z","timestamp":1789294519112,"version":"build-2803163510"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T00:00:00Z","timestamp":1518393600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"name":"Kongelig Hofbundtmager Aage Bangs Fond"},{"DOI":"10.13039\/100004423","name":"WHO","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,5,1]]},"DOI":"10.1093\/jac\/dky022","type":"journal-article","created":{"date-parts":[[2018,1,9]],"date-time":"2018-01-09T15:29:19Z","timestamp":1515511759000},"page":"1291-1294","source":"Crossref","is-referenced-by-count":40,"title":["In vitro activity of zoliflodacin (ETX0914) against macrolide-resistant, fluoroquinolone-resistant and antimicrobial-susceptible Mycoplasma genitalium strains"],"prefix":"10.1093","volume":"73","author":[{"given":"A C","family":"Dami\u00e3o Gouveia","sequence":"first","affiliation":[{"name":"Research Unit for Reproductive Tract Microbiology, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Unemo","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Gonorrhoea and Other Sexually Transmitted Infections, Department of Laboratory Medicine, Microbiology, \u00d6rebro University Hospital, \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7464-7435","authenticated-orcid":false,"given":"J S","family":"Jensen","sequence":"additional","affiliation":[{"name":"Research Unit for Reproductive Tract Microbiology, Statens Serum Institut, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,12]]},"reference":[{"key":"key\n\t\t\t\t20180420055714_dky022-B1","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1128\/CMR.00006-11","article-title":"Mycoplasma genitalium: from chrysalis to multicolored butterfly","volume":"24","author":"Taylor-Robinson","year":"2011","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20180420055714_dky022-B2","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1128\/AAC.02411-14","article-title":"In vitro activity of the new fluoroketolide solithromycin (CEM-101) against macrolide-resistant and -susceptible Mycoplasma genitalium strains","volume":"58","author":"Jensen","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180420055714_dky022-B3","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/cid\/civ312","article-title":"Mycoplasma genitalium infection and female reproductive tract disease: a meta-analysis","volume":"61","author":"Lis","year":"2015","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180420055714_dky022-B4","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1136\/sextrans-2013-051467","article-title":"Association between Mycoplasma genitalium infection and HIV acquisition among female sex workers in Uganda: evidence from a nested case-control study","volume":"90","author":"Vandepitte","year":"2014","journal-title":"Sex Transm Infect"},{"key":"key\n\t\t\t\t20180420055714_dky022-B5","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1093\/ije\/dyv194","article-title":"Epidemiology of Mycoplasma genitalium in British men and women aged 16-44 years: evidence from the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3)","volume":"44","author":"Sonnenberg","year":"2015","journal-title":"Int J Epidemiol"},{"key":"key\n\t\t\t\t20180420055714_dky022-B6","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nrurol.2016.268","article-title":"Antimicrobial-resistant sexually transmitted infections: gonorrhoea and Mycoplasma genitalium","volume":"14","author":"Unemo","year":"2017","journal-title":"Nat Rev Urol"},{"key":"key\n\t\t\t\t20180420055714_dky022-B7","first-page":"147","article-title":"Mycoplasma genitalium infection: current treatment options, therapeutic failure, and resistance-associated mutations","volume":"8","author":"Couldwell","year":"2015","journal-title":"Infect Drug Resist"},{"key":"key\n\t\t\t\t20180420055714_dky022-B8","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1128\/JCM.34.2.286-291.1996","article-title":"Isolation of Mycoplasma genitalium strains from the male urethra","volume":"34","author":"Jensen","year":"1996","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20180420055714_dky022-B9","doi-asserted-by":"crossref","first-page":"343.","DOI":"10.1186\/s12879-015-1041-6","article-title":"Management of Mycoplasma genitalium infections\u2014can we hit a moving target?","volume":"15","author":"Jensen","year":"2015","journal-title":"BMC Infect Dis"},{"key":"key\n\t\t\t\t20180420055714_dky022-B10","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1111\/jdv.13849","article-title":"2016 European guideline on Mycoplasma genitalium infections","volume":"30","author":"Jensen","year":"2016","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"key\n\t\t\t\t20180420055714_dky022-B11","doi-asserted-by":"crossref","first-page":"809","DOI":"10.3201\/eid2305.161745","article-title":"Increasing macrolide and fluoroquinolone resistance in Mycoplasma genitalium","volume":"23","author":"Murray","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20180420055714_dky022-B12","doi-asserted-by":"crossref","first-page":"S412","DOI":"10.1093\/infdis\/jix132","article-title":"New horizons in Mycoplasma genitalium treatment","volume":"216","author":"Bradshaw","year":"2017","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180420055714_dky022-B13","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1128\/AAC.04124-14","article-title":"In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase\/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-negative, and atypical bacteria","volume":"59","author":"Huband","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180420055714_dky022-B14","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1128\/AAC.03090-14","article-title":"High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug-resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea","volume":"58","author":"Jacobsson","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180420055714_dky022-B15","doi-asserted-by":"crossref","first-page":"3627","DOI":"10.1128\/AAC.04945-14","article-title":"In vitro antibacterial activity of AZD0914 against human mycoplasmas and ureaplasmas","volume":"59","author":"Waites","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180420055714_dky022-B16","doi-asserted-by":"crossref","first-page":"7595","DOI":"10.1128\/AAC.03920-14","article-title":"In vitro activity of AZD0914, a novel DNA gyrase inhibitor, against Chlamydia trachomatis and Chlamydia pneumoniae","volume":"58","author":"Kohlhoff","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180420055714_dky022-B17","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1128\/JCM.02056-06","article-title":"Isolation of Mycoplasma genitalium from first-void urine specimens by coculture with Vero cells","volume":"45","author":"Hamasuna","year":"2007","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20180420055714_dky022-B18","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1128\/JCM.42.2.683-692.2004","article-title":"Use of TaqMan 5\u2032 nuclease real-time PCR for quantitative detection of Mycoplasma genitalium DNA in males with and without urethritis who were attendees at a sexually transmitted disease clinic","volume":"42","author":"Jensen","year":"2004","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20180420055714_dky022-B19","doi-asserted-by":"crossref","first-page":"4993","DOI":"10.1128\/AAC.49.12.4993-4998.2005","article-title":"Antibiotic susceptibility testing of Mycoplasma genitalium by TaqMan 5\u2032 nuclease real-time PCR","volume":"49","author":"Hamasuna","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180420055714_dky022-B20","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.ijantimicag.2010.07.013","article-title":"gyrB and parE mutations in urinary Mycoplasma genitalium DNA from men with non-gonococcal urethritis","volume":"36","author":"Shimada","year":"2010","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20180420055714_dky022-B21","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1093\/cid\/civ644","article-title":"The efficacy of azithromycin for the treatment of genital Mycoplasma genitalium: a systematic review and meta-analysis","volume":"61","author":"Lau","year":"2015","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180420055714_dky022-B22","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1177\/0956462413502008","article-title":"Failure of moxifloxacin treatment in Mycoplasma genitalium infections due to macrolide and fluoroquinolone resistance","volume":"24","author":"Couldwell","year":"2013","journal-title":"Int J STD AIDS"},{"key":"key\n\t\t\t\t20180420055714_dky022-B23","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1093\/jac\/dku164","article-title":"Remarkable increase in fluoroquinolone-resistant Mycoplasma genitalium in Japan","volume":"69","author":"Kikuchi","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20180420055714_dky022-B24","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1093\/cid\/ciu1162","article-title":"Macrolide resistance and azithromycin failure in a Mycoplasma genitalium-infected cohort and response of azithromycin failures to alternative antibiotic regimens","volume":"60","author":"Bissessor","year":"2015","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20180420055714_dky022-B25","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1128\/AAC.04456-14","article-title":"Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae","volume":"59","author":"Alm","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180420055714_dky022-B26","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3389\/fmicb.2015.01377","article-title":"Genetic resistance determinants, in vitro time-kill curve analysis and pharmacodynamic functions for the novel topoisomerase II inhibitor ETX0914 (AZD0914) in Neisseria gonorrhoeae","volume":"6","author":"Foerster","year":"2015","journal-title":"Front Microbiol"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/73\/5\/1291\/24610125\/dky022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T07:19:50Z","timestamp":1603610390000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/73\/5\/1291\/4850948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,12]]},"references-count":26,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,2,12]]},"published-print":{"date-parts":[[2018,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dky022","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.732665559.793578630","asserted-by":"object"}]},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,5]]},"published":{"date-parts":[[2018,2,12]]}}}