{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:11:49Z","timestamp":1789938709731,"version":"4.0.1"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,9,1]]},"DOI":"10.1093\/jac\/dky192","type":"journal-article","created":{"date-parts":[[2018,4,27]],"date-time":"2018-04-27T19:08:47Z","timestamp":1524856127000},"page":"2422-2429","source":"Crossref","is-referenced-by-count":14,"title":["Model of population pharmacokinetics of cidofovir in immunocompromised children with cytomegalovirus and adenovirus infection"],"prefix":"10.1093","volume":"73","author":[{"given":"Nad\u00e8ge","family":"Neant","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Recherche Clinique, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Tarnier, Paris, France"},{"name":"EA7323, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Klifa","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Immunologie, H\u00e9matologie et Rhumatologie p\u00e9diatriques, AP-HP, H\u00f4pital universitaire Necker \u2013 Enfants malades, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na\u00efm","family":"Bouazza","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche Clinique, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Tarnier, Paris, France"},{"name":"EA7323, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina","family":"Moshous","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Immunologie, H\u00e9matologie et Rhumatologie p\u00e9diatriques, AP-HP, H\u00f4pital universitaire Necker \u2013 Enfants malades, Paris, France"},{"name":"INSERM UMR1163, Institut Imagine, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedicte","family":"Neven","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Immunologie, H\u00e9matologie et Rhumatologie p\u00e9diatriques, AP-HP, H\u00f4pital universitaire Necker \u2013 Enfants malades, Paris, France"},{"name":"INSERM UMR1163, Institut Imagine, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Leruez-Ville","sequence":"additional","affiliation":[{"name":"Laboratoire de Microbiologie clinique, AP-HP, H\u00f4pital Universitaire Necker \u2013 Enfants malades, Paris, France"},{"name":"EA7328, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Centre National de R\u00e9f\u00e9rence Herpes Virus, Laboratoire associ\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Blanche","sequence":"additional","affiliation":[{"name":"EA7323, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Unit\u00e9 d\u2019Immunologie, H\u00e9matologie et Rhumatologie p\u00e9diatriques, AP-HP, H\u00f4pital universitaire Necker \u2013 Enfants malades, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Treluyer","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche Clinique, Assistance Publique \u2013 H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Tarnier, Paris, France"},{"name":"EA7323, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Service de Pharmacologie clinique, AP-HP, Groupe hospitalier Paris Centre, H\u00f4pital Cochin, Paris, France"},{"name":"CIC-0901 INSERM, Cochin-Necker, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Hirt","sequence":"additional","affiliation":[{"name":"EA7323, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"},{"name":"Service de Pharmacologie clinique, AP-HP, Groupe hospitalier Paris Centre, H\u00f4pital Cochin, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Frange","sequence":"additional","affiliation":[{"name":"Unit\u00e9 d\u2019Immunologie, H\u00e9matologie et Rhumatologie p\u00e9diatriques, AP-HP, H\u00f4pital universitaire Necker \u2013 Enfants malades, Paris, France"},{"name":"Laboratoire de Microbiologie clinique, AP-HP, H\u00f4pital Universitaire Necker \u2013 Enfants malades, Paris, France"},{"name":"EA 7327, Universit\u00e9 Paris Descartes, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,1]]},"reference":[{"key":"key\n\t\t\t\t20180823025354_dky192-B1","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1128\/CMR.5.3.262","article-title":"Adenoviruses in the immunocompromised host","volume":"5","author":"Hierholzer","year":"1992","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20180823025354_dky192-B2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1177\/135965350501000204","article-title":"In vitro susceptibility of adenovirus to antiviral drugs is species-dependent","volume":"10","author":"Morfin","year":"2005","journal-title":"Antivir Ther"},{"key":"key\n\t\t\t\t20180823025354_dky192-B3","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/tid.12022","article-title":"European guidelines for diagnosis and treatment of adenovirus infection in leukemia and stem cell transplantation: summary of ECIL-4 (2011)","volume":"14","author":"Matthes-Martin","year":"2012","journal-title":"Transpl Infect Dis"},{"key":"key\n\t\t\t\t20180823025354_dky192-B4","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1128\/AAC.39.6.1247","article-title":"Clinical pharmacokinetics of cidofovir in human immunodeficiency virus-infected patients","volume":"39","author":"Cundy","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180823025354_dky192-B5","author":"European Medicines Agency"},{"key":"key\n\t\t\t\t20180823025354_dky192-B6","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1128\/AAC.04348-14","article-title":"Pharmacokinetics and safety of intravenous cidofovir for life-threatening viral infections in pediatric hematopoietic stem cell transplant recipients","volume":"59","author":"Caruso Brown","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20180823025354_dky192-B7","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.jpba.2010.06.034","article-title":"Determination of cidofovir in human plasma after low dose drug administration using high-performance liquid chromatography-tandem mass spectrometry","volume":"53","author":"Momper","year":"2010","journal-title":"J Pharm Biomed Anal"},{"key":"key\n\t\t\t\t20180823025354_dky192-B8","volume-title":"Foundations of Computer Science","author":"Aho","year":"1992"},{"key":"key\n\t\t\t\t20180823025354_dky192-B9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.pharmtox.48.113006.094708","article-title":"Mechanism-based concepts of size and maturity in pharmacokinetics","volume":"48","author":"Anderson","year":"2008","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"key\n\t\t\t\t20180823025354_dky192-B10","volume-title":"Pharmacokinetic-Pharmacodynamic Modeling and Simulation","author":"10","year":"2011"},{"key":"key\n\t\t\t\t20180823025354_dky192-B11","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/sj.clpt.6100241","article-title":"Diagnosing model diagnostics","volume":"82","author":"Karlsson","year":"2007","journal-title":"Clin Pharmacol Ther"},{"key":"key\n\t\t\t\t20180823025354_dky192-B12","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1007\/s11095-007-9361-x","article-title":"Conditional weighted residuals (CWRES): a model diagnostic for the FOCE method","volume":"24","author":"Hooker","year":"2007","journal-title":"Pharm Res"},{"key":"key\n\t\t\t\t20180823025354_dky192-B13","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1208\/s12248-011-9255-z","article-title":"Prediction-corrected visual predictive checks for diagnosing nonlinear mixed-effects models","volume":"13","author":"Bergstrand","year":"2011","journal-title":"AAPS J"},{"key":"key\n\t\t\t\t20180823025354_dky192-B14","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/0006-2952(93)90670-R","article-title":"Mechanism of uptake of the phosphonate analog (S)-1-(3-hydroxy-2-phosphonylmethoxy-propyl)cytosine (HPMPC) in vero cells","volume":"46","author":"Connelly","year":"1993","journal-title":"Biochem Pharmacol"},{"key":"key\n\t\t\t\t20180823025354_dky192-B15","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1128\/CMR.16.4.569-596.2003","article-title":"Clinical potential of the acyclic nucleoside phosphonates cidofovir, adefovir, and tenofovir in treatment of DNA virus and retrovirus infections","volume":"16","author":"De Clercq","year":"2003","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20180823025354_dky192-B16","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.bbmt.2016.12.621","article-title":"Brincidofovir for asymptomatic adenovirus viremia in pediatric and adult allogeneic hematopoietic cell transplant recipients: a randomized placebo-controlled Phase II trial","volume":"23","author":"Grimley","year":"2017","journal-title":"Biol Blood Marrow Transplant"},{"key":"key\n\t\t\t\t20180823025354_dky192-B17","doi-asserted-by":"crossref","first-page":"758.","DOI":"10.12688\/f1000research.8374.2","article-title":"Use of cidofovir in pediatric patients with adenovirus infection","volume":"5","author":"Ganapathi","year":"2016","journal-title":"F1000Res"},{"key":"key\n\t\t\t\t20180823025354_dky192-B18","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1182\/blood-2016-11-749721","article-title":"Brincidofovir is highly efficacious in controlling adenoviremia in pediatric recipients of hematopoietic cell transplant","volume":"129","author":"Hiwarkar","year":"2017","journal-title":"Blood"},{"key":"key\n\t\t\t\t20180823025354_dky192-B19","first-page":"526","article-title":"Rising antigenemia levels may be misleading in pre-emptive therapy of human cytomegalovirus infection in allogeneic hematopoietic stem cell transplant recipients","volume":"90","author":"Gerna","year":"2005","journal-title":"Haematologica"},{"key":"key\n\t\t\t\t20180823025354_dky192-B20","doi-asserted-by":"crossref","first-page":"4179","DOI":"10.1128\/JCM.05464-11","article-title":"Paradoxical rising cytomegalovirus antigenemia during preemptive ganciclovir therapy in hematopoietic stem cell transplant recipients: incidence, risk factors, and clinical outcomes","volume":"49","author":"Park","year":"2011","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20180823025354_dky192-B21","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1128\/CMR.00116-13","article-title":"Adenovirus infections in immunocompetent and immunocompromised patients","volume":"27","author":"Lion","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t20180823025354_dky192-B22","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/leu.2010.4","article-title":"Monitoring of adenovirus load in stool by real-time PCR permits early detection of impending invasive infection in patients after allogeneic stem cell transplantation","volume":"24","author":"Lion","year":"2010","journal-title":"Leukemia"},{"key":"key\n\t\t\t\t20180823025354_dky192-B23","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1038\/sj.bmt.1702716","article-title":"Outcome and clinical course of 100 patients with adenovirus infection following bone marrow transplantation","volume":"26","author":"Baldwin","year":"2000","journal-title":"Bone Marrow Transplant"},{"key":"key\n\t\t\t\t20180823025354_dky192-B24","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1086\/427513","article-title":"Immune reconstitution and clearance of human adenovirus viremia in pediatric stem-cell recipients","volume":"191","author":"Heemskerk","year":"2005","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20180823025354_dky192-B25","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.jaci.2016.03.032","article-title":"Specific T cells for the treatment of cytomegalovirus and\/or adenovirus in the context of hematopoietic stem cell transplantation","volume":"138","author":"Creidy","year":"2016","journal-title":"J Allergy Clin Immunol"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/73\/9\/2422\/25523226\/dky192.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T06:58:53Z","timestamp":1661065133000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/73\/9\/2422\/5026318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,1]]},"references-count":25,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2018,6,1]]},"published-print":{"date-parts":[[2018,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dky192","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,9]]},"published":{"date-parts":[[2018,6,1]]}}}