{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:57:12Z","timestamp":1790009832014,"version":"4.0.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2018,7,19]],"date-time":"2018-07-19T00:00:00Z","timestamp":1531958400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Cidara Therapeutics, Inc"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,1]]},"DOI":"10.1093\/jac\/dky280","type":"journal-article","created":{"date-parts":[[2018,6,21]],"date-time":"2018-06-21T15:09:09Z","timestamp":1529593749000},"page":"3063-3067","source":"Crossref","is-referenced-by-count":92,"title":["Rezafungin (CD101) demonstrates potent in vitro activity against Aspergillus, including azole-resistant Aspergillus fumigatus isolates and cryptic species"],"prefix":"10.1093","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-5122","authenticated-orcid":false,"given":"Nathan P","family":"Wiederhold","sequence":"first","affiliation":[{"name":"Fungus Testing Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B","family":"Locke","sequence":"additional","affiliation":[{"name":"Cidara Therapeutics, Inc., San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Daruwala","sequence":"additional","affiliation":[{"name":"Cidara Therapeutics, Inc., San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Bartizal","sequence":"additional","affiliation":[{"name":"Cidara Therapeutics, Inc., San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,7,18]]},"reference":[{"key":"key\n\t\t\t\t20181023055159397_dky280-B1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.drup.2015.08.001","article-title":"International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus","volume":"21\u201322","author":"Verweij","year":"2015","journal-title":"Drug Resist Updat"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B2","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1093\/jac\/dku477","article-title":"A rationale for reduced-frequency dosing of anidulafungin for antifungal prophylaxis in immunocompromised patients","volume":"70","author":"Bruggemann","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B3","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1093\/jac\/dku544","article-title":"Micafungin twice weekly as antifungal prophylaxis in paediatric patients at high risk for invasive fungal disease","volume":"70","author":"Bochennek","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B4","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ijantimicag.2017.03.028","article-title":"CD101, a long-acting echinocandin, and comparator antifungal agents tested against a global collection of invasive fungal isolates in the SENTRY 2015 Antifungal Surveillance Program","volume":"50","author":"Pfaller","year":"2017","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B5","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1093\/jac\/dkw214","article-title":"Activity of a long-acting echinocandin, CD101, determined using CLSI and EUCAST reference methods, against Candida and Aspergillus spp., including echinocandin- and azole-resistant isolates","volume":"71","author":"Pfaller","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B6","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/ja.2016.89","article-title":"CD101, a novel echinocandin with exceptional stability properties and enhanced aqueous solubility","volume":"70","author":"Krishnan","year":"2017","journal-title":"J Antibiot (Tokyo)"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B7","doi-asserted-by":"crossref","first-page":"e01627","DOI":"10.1128\/AAC.01627-16","article-title":"Safety and pharmacokinetics of CD101 IV, a novel echinocandin, in healthy adults","volume":"61","author":"Sandison","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B8","doi-asserted-by":"crossref","first-page":"e01541","DOI":"10.1128\/AAC.01541-16","article-title":"Structure-activity relationships of a series of echinocandins and the discovery of CD101, a highly stable and soluble echinocandin with distinctive pharmacokinetic properties","volume":"61","author":"James","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B9","doi-asserted-by":"crossref","first-page":"e01626-16.","DOI":"10.1128\/AAC.01626-16","article-title":"Pharmacokinetics of the novel echinocandin CD101 in multiple animal species","volume":"61","author":"Ong","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B10","doi-asserted-by":"crossref","first-page":"e00758-17.","DOI":"10.1128\/AAC.00758-17","article-title":"Pharmacological basis of CD101 efficacy: exposure shape matters","volume":"61","author":"Lakota","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.simyco.2014.07.004","article-title":"Phylogeny, identification and nomenclature of the genus Aspergillus","volume":"78","author":"Samson","year":"2014","journal-title":"Stud Mycol"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B12","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1128\/JCM.02478-15","article-title":"First detection of TR34 L98H and TR46 Y121F T289A Cyp51 mutations in Aspergillus fumigatus isolates in the United States","volume":"54","author":"Wiederhold","year":"2016","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B13","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi\u2014Second Edition: Approved Standard M38-A2","author":"Clinical and Laboratory Standards Institute","year":"2008"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B14","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1128\/JCM.00854-09","article-title":"Patterns of susceptibility of Aspergillus isolates recovered from patients enrolled in the Transplant-Associated Infection Surveillance Network","volume":"47","author":"Baddley","year":"2009","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B15","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1128\/AAC.00942-07","article-title":"Aspergillus section Fumigati: antifungal susceptibility patterns and sequence-based identification","volume":"52","author":"Alcazar-Fuoli","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B16","volume-title":"Abstracts of ASM Microbe 2018, Atlanta, GA, USA","author":"Thompson","year":"2018"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B17","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1093\/jac\/dkn069","article-title":"Comparison of the dose-dependent activity and paradoxical effect of caspofungin and micafungin in a neutropenic murine model of invasive pulmonary aspergillosis","volume":"61","author":"Lewis","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B18","doi-asserted-by":"crossref","first-page":"S369","DOI":"10.1080\/13693780802428542","article-title":"Paradoxical echinocandin activity: a limited in vitro phenomenon?","volume":"47","author":"Wiederhold","year":"2009","journal-title":"Med Mycol"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B19","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1086\/424465","article-title":"Pharmacodynamics of caspofungin in a murine model of invasive pulmonary aspergillosis: evidence of concentration-dependent activity","volume":"190","author":"Wiederhold","year":"2004","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B20","doi-asserted-by":"crossref","first-page":"S389","DOI":"10.1016\/j.bbmt.2017.12.484","article-title":"CD101 prophylactic dose rationale for prevention of Aspergillus, Candida, and Pneumocystis infections","volume":"24","author":"Flanagan","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B21","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1128\/AAC.00105-07","article-title":"In vivo efficacy of anidulafungin and caspofungin against Candida glabrata and association with in vitro potency in the presence of sera","volume":"51","author":"Wiederhold","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20181023055159397_dky280-B22","volume-title":"Abstracts of the Eighth Advances against Aspergillosis Meeting, Lisbon, Portugal","author":"Ong","year":"2018"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/73\/11\/3063\/26144555\/dky280.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T23:58:15Z","timestamp":1661471895000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/73\/11\/3063\/5055842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,18]]},"references-count":22,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,7,18]]},"published-print":{"date-parts":[[2018,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dky280","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,11]]},"published":{"date-parts":[[2018,7,18]]}}}