{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T06:11:35Z","timestamp":1790057495271,"version":"4.0.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T00:00:00Z","timestamp":1536278400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"national French programme"},{"name":"PHRC"},{"name":"Programme Hospitalier de Recherche Clinique"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,12,1]]},"DOI":"10.1093\/jac\/dky328","type":"journal-article","created":{"date-parts":[[2018,7,23]],"date-time":"2018-07-23T13:40:32Z","timestamp":1532353232000},"page":"3423-3429","source":"Crossref","is-referenced-by-count":13,"title":["Variability of ciprofloxacin pharmacokinetics in children: impact on dose range in sickle cell patients"],"prefix":"10.1093","volume":"73","author":[{"given":"A","family":"Facchin","sequence":"first","affiliation":[{"name":"D\u00e9partement de Pharmacologie P\u00e9diatrique et pharmacog\u00e9n\u00e9tique, CHU Robert Debr\u00e9 APHP, Paris, France"},{"name":"Ecole Doctorale MTCI, Universit\u00e9 Paris Descartes, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Bui","sequence":"additional","affiliation":[{"name":"D\u00e9partement de P\u00e9diatrie, CIC1401, CHU de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Leroux","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie P\u00e9diatrique et pharmacog\u00e9n\u00e9tique, CHU Robert Debr\u00e9 APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Nacka","sequence":"additional","affiliation":[{"name":"D\u00e9partement de P\u00e9diatrie, CIC1401, CHU de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Koehl","sequence":"additional","affiliation":[{"name":"Service d\u2019h\u00e9matologie, Centre de r\u00e9f\u00e9rence de la dr\u00e9panocytose, H\u00f4pital Robert Debr\u00e9, APHP, Paris, France"},{"name":"D\u00e9partement de P\u00e9diatrie, H\u00f4pital Robert Debr\u00e9, APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Maksoud","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie P\u00e9diatrique et pharmacog\u00e9n\u00e9tique, CHU Robert Debr\u00e9 APHP, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Fayon","sequence":"additional","affiliation":[{"name":"D\u00e9partement de P\u00e9diatrie, CIC1401, CHU de Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Jacqz-Aigrain","sequence":"additional","affiliation":[{"name":"D\u00e9partement de Pharmacologie P\u00e9diatrique et pharmacog\u00e9n\u00e9tique, CHU Robert Debr\u00e9 APHP, Paris, France"},{"name":"Universit\u00e9 Paris Diderot, Sorbonne Paris-Cit\u00e9, Paris, France"},{"name":"Centre d\u2019investigation clinique, CIC1426, INSERM, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"with the assistance of the Paediatric Clinical Investigation Centres Pharmacology Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,9,6]]},"reference":[{"key":"key\n\t\t\t\t2018112102524053700_dky328-B1","author":"Bayer Healthcare"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B2","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/adc.2010.208843","article-title":"Ciprofloxacin safety in paediatrics: a systematic review","volume":"96","author":"Adefurin","year":"2011","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/030098589002700303","article-title":"Histologic and histochemical changes in articular cartilages of immature beagle dogs dosed with difloxacin, a fluoroquinolone","volume":"27","author":"Burkhardt","year":"1990","journal-title":"Vet Pathol"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B4","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1128\/AAC.37.5.1073","article-title":"Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients","volume":"37","author":"Forrest","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B5","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1128\/AAC.47.10.3170-3178.2003","article-title":"Population pharmacokinetics of ciprofloxacin in pediatric and adolescent patients with acute infections","volume":"47","author":"Payen","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1128\/AAC.40.1.29","article-title":"Pharmacokinetics of ciprofloxacin in pediatric cystic fibrosis patients","volume":"40","author":"Schaefer","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B7","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1177\/0091270003254802","article-title":"Population pharmacokinetics of ciprofloxacin in pediatric patients","volume":"43","author":"Rajagopalan","year":"2003","journal-title":"J Clin Pharmacol"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B8","doi-asserted-by":"crossref","first-page":"6572","DOI":"10.1128\/AAC.03568-14","article-title":"Population pharmacokinetics of ciprofloxacin in neonates and young infants less than three months of age","volume":"58","author":"Zhao","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B9","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1542\/peds.101.4.658","article-title":"Single-dose and steady-state pharmacokinetics of a new oral suspension of ciprofloxacin in children","volume":"101","author":"Peltola","year":"1998","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B10","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1128\/AAC.36.5.1086","article-title":"Pharmacokinetics of single-dose oral ciprofloxacin in infants and small children","volume":"36","author":"Peltola","year":"1992","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B11","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1093\/jac\/dkr314","article-title":"Dosing regimens of oral ciprofloxacin for children with severe malnutrition: a population pharmacokinetic study with Monte Carlo simulation","volume":"66","author":"Thuo","year":"2011","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B12","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1002\/bmc.1523","article-title":"Determination of ciprofloxacin in plasma by micro-liquid chromatography-mass spectrometry: an adapted method for neonates","volume":"25","author":"Grondin","year":"2011","journal-title":"Biomed Chromatogr"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B13"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B14","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1146\/annurev.pharmtox.48.113006.094708","article-title":"Mechanism-based concepts of size and maturity in pharmacokinetics","volume":"48","author":"Anderson","year":"2008","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B15","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2009.06.060","article-title":"Renal function in infants with sickle cell anemia: baseline data from the BABY HUG trial","volume":"156","author":"Ware","year":"2010","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B16","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1007\/s00467-010-1736-2","article-title":"Sickle cell nephropathy: challenging the conventional wisdom","volume":"26","author":"Becker","year":"2011","journal-title":"Pediatr Nephrol"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1681\/ASN.V101187","article-title":"Sickle cell nephropathy","volume":"10","author":"Saborio","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B18","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1365-2710.2011.01261.x","article-title":"Sub-optimal serum gentamicin concentrations in sickle cell disease patients utilizing the Hartford protocol","volume":"37","author":"Abusham","year":"2012","journal-title":"J Clin Pharm Ther"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B19","doi-asserted-by":"crossref","first-page":"756","DOI":"10.2215\/CJN.08511109","article-title":"Glomerular hyperfiltration in adult sickle cell anemia: a frequent hemolysis associated feature","volume":"5","author":"Haymann","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B20","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/S0022-3476(98)70396-8","article-title":"Hepatic function as assessed by lidocaine metabolism in sickle cell disease","volume":"132","author":"Gremse","year":"1998","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B21","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1124\/dmd.32.1.98","article-title":"Metabolism of opioids is altered in liver microsomes of sickle cell transgenic mice","volume":"32","author":"Nagar","year":"2004","journal-title":"Drug Metab Dispos"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B22","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.jpain.2010.10.012","article-title":"Increased clearance of morphine in sickle cell disease: implications for pain management","volume":"12","author":"Darbari","year":"2011","journal-title":"J Pain"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B23","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/j.1552-4604.1993.tb01956.x","article-title":"Codeine disposition in sickle cell patients compared with healthy volunteers","volume":"33","author":"Mohammed","year":"1993","journal-title":"J Clin Pharmacol"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B24","first-page":"316","article-title":"Incidence and predictors of bacterial infection in febrile children with sickle cell disease","volume":"39","author":"Morrissey","year":"2015","journal-title":"Hemoglobin"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B25","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1136\/adc.80.6.537","article-title":"Recurrent infections in homozygous sickle cell disease","volume":"80","author":"Magnus","year":"1999","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B26","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1067\/S0022-3476(03)00331-7","article-title":"Invasive pneumococcal infections in children with sickle cell disease in the era of penicillin prophylaxis, antibiotic resistance, and 23-valent pneumococcal polysaccharide vaccination","volume":"143","author":"Adamkiewicz","year":"2003","journal-title":"J Pediatr"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B27"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B28","first-page":"191","article-title":"The perils of prescribing fluoroquinolones","volume":"62","author":"Heidelbaugh","year":"2013","journal-title":"J Fam Pract"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B29","doi-asserted-by":"crossref","first-page":"e1034","DOI":"10.1542\/peds.2011-1496","article-title":"The use of systemic and topical fluoroquinolones","volume":"128","author":"Bradley","year":"2011","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B30","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1097\/01.inf.0000101994.25947.12","article-title":"Safety profile of quinolone antibiotics in the pediatric population","volume":"22","author":"Grady","year":"2003","journal-title":"Pediatr Infect Dis J"},{"key":"key\n\t\t\t\t2018112102524053700_dky328-B31","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1177\/0009922815599959","article-title":"The risk of musculoskeletal adverse events with fluoroquinolones in children: what is the verdict now?","volume":"55","author":"Binz","year":"2016","journal-title":"Clin Pediatr (Phila)"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/73\/12\/3423\/26651016\/dky328.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,28]],"date-time":"2022-08-28T02:11:56Z","timestamp":1661652716000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/73\/12\/3423\/5091851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,6]]},"references-count":31,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,9,6]]},"published-print":{"date-parts":[[2018,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dky328","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,12]]},"published":{"date-parts":[[2018,9,6]]}}}