{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:11:27Z","timestamp":1769170287948,"version":"3.49.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Genomics Research Development Initiative"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/jac\/dky391","type":"journal-article","created":{"date-parts":[[2018,9,6]],"date-time":"2018-09-06T19:13:12Z","timestamp":1536261192000},"source":"Crossref","is-referenced-by-count":11,"title":["WGS analysis of a penicillin-resistant Neisseria meningitidis strain containing a chromosomal ROB-1 \u03b2-lactamase gene"],"prefix":"10.1093","author":[{"given":"Raymond S W","family":"Tsang","sequence":"first","affiliation":[{"name":"Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tauqeer","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Vaccine Preventable Bacterial Diseases, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frances B","family":"Jamieson","sequence":"additional","affiliation":[{"name":"Public Health Ontario, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory J","family":"Tyrrell","sequence":"additional","affiliation":[{"name":"Provincial Laboratory for Public Health and Division of Diagnostic and Applied Microbiology, Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,10,8]]},"reference":[{"key":"key\n\t\t\t\t20181008101233951_dky391-B1","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1056\/NEJM200105033441807","article-title":"Meningococcal disease","volume":"344","author":"Rosenstein","year":"2001","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B2","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1093\/clinids\/7.4.504","article-title":"Serotype antigens of Neisseria meningitidis and a proposed scheme for designation of serotypes","volume":"7","author":"Frasch","year":"1985","journal-title":"Rev Infect Dis"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B3","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1073\/pnas.95.6.3140","article-title":"Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms","volume":"95","author":"Maiden","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1708-8305.2010.00448.x","article-title":"Meningococcal disease: the organism, clinical presentation, and worldwide epidemiology","volume":"17","author":"Al-Tawfiq","year":"2010","journal-title":"J Travel Med"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B5","doi-asserted-by":"crossref","first-page":"2852","DOI":"10.1016\/j.vaccine.2013.04.036","article-title":"Emergence of serogroup X meningococcal disease in Africa: need for a vaccine","volume":"31","author":"Xie","year":"2013","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B6","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1699-0463.1998.tb01379.x","article-title":"Population genetics and molecular epidemiology of Neisseria meningitidis","volume":"106","author":"Caugant","year":"1998","journal-title":"APMIS"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B7","doi-asserted-by":"crossref","first-page":"B51","DOI":"10.1016\/j.vaccine.2009.04.063","article-title":"Global epidemiology of meningococcal disease","volume":"27","author":"Harrison","year":"2009","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B8","doi-asserted-by":"crossref","first-page":"5146","DOI":"10.1128\/JCM.42.11.5146-5153.2004","article-title":"Distribution of serogroups and genotypes among disease-associated and carried isolates of Neisseria meningitidis from the Czech Republic, Greece, and Norway","volume":"42","author":"Yazdankhah","year":"2014","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B9","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1093\/clinids\/24.Supplement_1.S98","article-title":"Antibiotic resistance in Neisseria meningitidis","volume":"24","author":"Oppenheim","year":"1997","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B10","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1093\/jac\/dkg452","article-title":"Chloramphenicol-resistant Neisseria meningitidis containing catP isolated in Australia","volume":"52","author":"Shultz","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/jac\/dkl484","article-title":"Emerging fluoroquinolone resistance in Neisseria meningitidis in India: cause for concern","volume":"59","author":"Mehta","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B12","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1056\/NEJMoa0806414","article-title":"Emergence of ciprofloxacin-resistant Neisseria meningitidis in North America","volume":"360","author":"Wu","year":"2009","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B13","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.jadohealth.2016.04.013","article-title":"Treatment of meningococcal disease","volume":"59","author":"Nadel","year":"2016","journal-title":"J Adolesc Health"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B14","author":"HPA","year":"2012"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B15","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/S0140-6736(83)91846-9","article-title":"Spread of penicillinase-producing and transfer plasmids from the gonococcus to Neisseria meningitidis","volume":"i","author":"Dillon","year":"1983","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B16","doi-asserted-by":"crossref","first-page":"54.","DOI":"10.1016\/S0140-6736(88)91029-X","article-title":"Penicillin-resistant Neisseria meningitidis in Southern Africa","volume":"i","author":"Botha","year":"1988","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1007\/BF01964130","article-title":"Penicillin-resistant \u03b2-lactamase producing Neisseria meningitidis in Spain","volume":"8","author":"Fontanals","year":"1989","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B18","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/BF01591498","article-title":"Isolation of a \u03b2-lactamase producing Neisseria meningitidis in Spain","volume":"15","author":"Vazquez","year":"1996","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B19","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing: Twenty-Eighth Edition M100-ED28","author":"Clinical and Laboratory Standards Institute","year":"2018"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B20","doi-asserted-by":"crossref","first-page":"e1061","DOI":"10.1542\/peds.2005-1994","article-title":"Pneumonia and empyema caused by penicillin-resistant Neisseria meningitidis: a case report and literature review","volume":"117","author":"Glikman","year":"2006","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B21","doi-asserted-by":"crossref","first-page":"342","DOI":"10.33321\/cdi.2010.34.36","article-title":"Penicillin-resistant Neisseria meningitidis bacteremia, Kimberley region, March 2010","volume":"34","author":"Abeysuriya","year":"2010","journal-title":"Commun Dis Intell"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B22","doi-asserted-by":"crossref","first-page":"31529","DOI":"10.1074\/jbc.M304607200","article-title":"Correlation between alterations of the penicillin-binding protein 2 and modifications of the peptidoglycan structure in Neisseria meningitidis with reduced susceptibility to penicillin G","volume":"278","author":"Antignac","year":"2003","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B23","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1128\/AAC.01077-09","article-title":"Epidemiology of invasive meningococcal disease with decreased susceptibility to penicillin in Ontario, Canada, 2000 to 2006","volume":"54","author":"Brown","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B24","doi-asserted-by":"crossref","first-page":"13564","DOI":"10.3201\/eid2308.170259","article-title":"Clonal expansion of new penicillin-resistant clade of Neisseria meningitidis serogroup W clonal complex 11, Australia","volume":"23","author":"Mowlaboccus","year":"2017","journal-title":"Emerg Infect Dis"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B25","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/jac\/dkw400","article-title":"Emergence of meningococci with reduced susceptibility to third-generation cephalosporin","volume":"72","author":"Deghmane","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B26","doi-asserted-by":"crossref","first-page":"595.","DOI":"10.1186\/1471-2105-11-595","article-title":"BIGSdb: scalable analysis of bacterial genome variation at the population level","volume":"11","author":"Jolley","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B27","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1128\/JCM.06835-11","article-title":"Invasive serogroup B Neisseria meningitidis in Quebec, Canada, 2003 to 2010: persistence of the ST-269 clone since it first emerged in 2003","volume":"50","author":"Zhou","year":"2012","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s12866-015-0469-6","article-title":"Characterization of invasive Neisseria meningitidis strains from Quebec, Canada, during a period of increased serogroup B disease, 2009-2013: phenotyping and genotyping with special emphasis on the non-carbohydrate protein vaccine targets","volume":"15","author":"Law","year":"2015","journal-title":"BMC Microbiol"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B29","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1128\/AAC.38.7.1678","article-title":"Determination of antimicrobial susceptibilities of Canadian isolates of Haemophilus influenzae and characterization of their \u03b2-lactamases. Canadian Haemophilus Study Group","volume":"38","author":"Scriver","year":"1994","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B30","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1089\/cmb.2012.0021","article-title":"SPAdes: a new genome assembly algorithm and its applications to single-cell sequencing","volume":"19","author":"Bankevich","year":"2012","journal-title":"J Comput Biol"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B31","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1093\/bioinformatics\/btu153","article-title":"Prokka: rapid prokarytic genome annotation","volume":"30","author":"Seemann","year":"2014","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B32","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1186\/1471-2164-15-1138","article-title":"A gene-by-gene population genomics platform: de novo assembly, annotation and genealogical analysis of 108 representative Neisseria meningitidis genomes","volume":"15","author":"Bratcher","year":"2014","journal-title":"BMC Genomics"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B33","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1093\/bioinformatics\/14.1.68","article-title":"SplitsTree: analyzing and visualizing evolutionary data","volume":"14","author":"Huson","year":"1998","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B34","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1093\/bioinformatics\/btq588","article-title":"Interactive microbial genome visualisation with GView","volume":"26","author":"Petkau","year":"2010","journal-title":"Bioinformatics"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0167-7012(01)00364-5","article-title":"A one-step method for genetic transformation of non-piliated Neisseria meningitidis","volume":"49","author":"Bogdan","year":"2002","journal-title":"J Microbiol Methods"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B36","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/S0140-6736(81)91214-9","article-title":"Ampicillin treatment failure of apparently \u03b2-lactamase negative Haemophilus influenzae type b meningitis due to novel \u03b2-lactamase","volume":"ii","author":"Rubin","year":"1981","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B37","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1128\/AAC.29.2.212","article-title":"An animal source for the ROB-1 \u03b2-lactamase of Haemohilus influenzae type b","volume":"29","author":"Medeiros","year":"1986","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B38","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1128\/AAC.35.11.2419","article-title":"Plasmid-mediated ROB-1 \u03b2-lactamase in Pasteurella multicodia from a human specimen","volume":"35","author":"Rosenau","year":"1991","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B39","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1128\/AAC.35.7.1397","article-title":"Molecular distribution of ROB-1 \u03b2-lactamase in Actinobacillus pleuropneumonniae","volume":"35","author":"Juteau","year":"1991","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B40","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/jac\/dki281","article-title":"Global distribution of TEM-1 and ROB-1 \u03b2-lactamases in Haemophilus influenzae","volume":"56","author":"Farrell","year":"2005","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B41","first-page":"1314","article-title":"Antibiotic susceptibility and molecular analysis of invasive Haemophilus influenzae in Canada, 2007 to 2014","volume":"72","author":"Tsang","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B42","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/35006655","article-title":"Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491","volume":"404","author":"Parkhill","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B43","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1126\/science.287.5459.1809","article-title":"Complete genome sequence of Neisseria meningitidis serogroup B strain MC58","volume":"287","author":"Tettelin","year":"2000","journal-title":"Science"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B44","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1128\/AAC.01489-09","article-title":"Haemophilus influenzae clinical isolates with plasmid pB1000 bearing blaROB-1: fitness cost and interspecies dissemination","volume":"54","author":"Millan","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B45","doi-asserted-by":"crossref","first-page":"12381","DOI":"10.1073\/pnas.95.21.12381","article-title":"Natural genetic exchange between Haemophilus and Neisseria: intergeneric transfer of chromosomal genes between major human pathogens","volume":"95","author":"Kroll","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B46","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1128\/AAC.32.8.1282","article-title":"Genetic determinant of the ROB-1 \u03b2-lactamase in bovine and porcine Pasteurella strains","volume":"32","author":"Livrelli","year":"1988","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B47","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1128\/JCM.02134-06","article-title":"Genetic and antigenic analysis of invasive serogroup Y Neisseria meningitidis isolates collected from 1999 to 2003 in Canada","volume":"45","author":"Tsang","year":"2007","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B48","doi-asserted-by":"crossref","first-page":"e00831","DOI":"10.1128\/AAC.00831-18","article-title":"Acquisition of \u03b2-lactamase by Neisseria meningitidis through possible horizontal gene transfer","volume":"62","author":"Hong","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B49","doi-asserted-by":"crossref","first-page":"68","DOI":"10.4161\/hv.7.0.14564","article-title":"Preclinical evidence for the potential of a bivalent fHBP vaccine to prevent Neisseria meningitidis serogroup C disease","volume":"7","author":"Harris","year":"2011","journal-title":"Hum Vaccin"},{"key":"key\n\t\t\t\t20181008101233951_dky391-B50","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3201\/eid2202.150369","article-title":"Effectiveness of meningococcal B vaccine against endemic hypervirulent Neisseria meningitidis W strain, England","volume":"22","author":"Ladhani","year":"2016","journal-title":"Emerg Infect Dis"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/advance-article-pdf\/doi\/10.1093\/jac\/dky391\/25953068\/dky391.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T23:05:54Z","timestamp":1751843154000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/advance-article\/doi\/10.1093\/jac\/dky391\/5123547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,8]]},"references-count":50,"URL":"https:\/\/doi.org\/10.1093\/jac\/dky391","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,8]]}}}