{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:58:45Z","timestamp":1791939525497,"version":"4.3.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2018,11,2]],"date-time":"2018-11-02T00:00:00Z","timestamp":1541116800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NIHR Policy Research Programme"},{"name":"Defining Reservoirs of ESBL-Producing E. coli"},{"name":"Threat Posed to Personal, Animal and Public Health"},{"name":"Independent Research","award":["PRP 041\/0039"],"award-info":[{"award-number":["PRP 041\/0039"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,2,1]]},"DOI":"10.1093\/jac\/dky453","type":"journal-article","created":{"date-parts":[[2018,10,10]],"date-time":"2018-10-10T21:15:59Z","timestamp":1539206159000},"page":"326-333","source":"Crossref","is-referenced-by-count":127,"title":["OXA-1 \u03b2-lactamase and non-susceptibility to penicillin\/\u03b2-lactamase inhibitor combinations among ESBL-producing<i>Escherichia coli<\/i>"],"prefix":"10.1093","volume":"74","author":[{"given":"David M","family":"Livermore","sequence":"first","affiliation":[{"name":"Antimicrobial Resistance and Healthcare-Associated Infections Reference Unit, PHE National Infection Service, London, UK"},{"name":"Norwich Medical School, University of East Anglia, Norwich, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Day","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance and Healthcare-Associated Infections Reference Unit, PHE National Infection Service, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Cleary","sequence":"additional","affiliation":[{"name":"PHE Field Service, Liverpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie L","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance and Healthcare-Associated Infections Reference Unit, PHE National Infection Service, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A","family":"Toleman","sequence":"additional","affiliation":[{"name":"Cardiff University, Heath Park Campus, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W","family":"Wareham","sequence":"additional","affiliation":[{"name":"Blizard Institute, Queen Mary University of London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Wiuff","sequence":"additional","affiliation":[{"name":"Health Protection Scotland, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Doumith","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance and Healthcare-Associated Infections Reference Unit, PHE National Infection Service, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Woodford","sequence":"additional","affiliation":[{"name":"Antimicrobial Resistance and Healthcare-Associated Infections Reference Unit, PHE National Infection Service, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,11,2]]},"reference":[{"key":"key\n\t\t\t\t2019012509364548400_dky453-B1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/jac\/dku328","article-title":"Longitudinal trends and cross-sectional analysis of English national hospital antibacterial use over 5 years (2008\u201313): working towards hospital prescribing quality measures","volume":"70","author":"Cooke","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B2","doi-asserted-by":"crossref","first-page":"e01917","DOI":"10.1128\/JCM.01917-17","article-title":"Point-counterpoint: piperacillin-tazobactam should be used to treat infections with ESBL-positive organisms","volume":"56","author":"Schuetz","year":"2018","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B3","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1093\/jac\/dkf240","article-title":"Biochemical analysis of the ceftazidime-hydrolysing extended-spectrum \u03b2-lactamase CTX-M-15 and of its structurally related \u03b2-lactamase CTX-M-3","volume":"50","author":"Poirel","year":"2002","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B4","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1128\/AAC.37.4.851","article-title":"Kinetic interactions of tazobactam with \u03b2-lactamases from all major structural classes","volume":"37","author":"Bush","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B5","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1128\/CMR.00037-09","article-title":"Three decades of \u03b2-lactamase inhibitors","volume":"23","author":"Drawz","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B6","doi-asserted-by":"crossref","first-page":"9912","DOI":"10.1021\/bi9012098","article-title":"Why the extended-spectrum \u03b2-lactamases SHV-2 and SHV-5 are \u201chypersusceptible\u201d to mechanism-based inhibitors","volume":"48","author":"Kalp","year":"2009","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B7","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.diagmicrobio.2011.03.021","article-title":"Antimicrobial susceptibility of global inpatient urinary tract isolates of Escherichia coli: results from the Study for Monitoring Antimicrobial Resistance Trends (SMART) program: 2009\u20132010","volume":"70","author":"Hoban","year":"2011","journal-title":"Diagn Microbiol Infect Dis"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B8","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1007\/s10096-018-3274-y","article-title":"Activity of ertapenem against Enterobacteriaceae in seven global regions\u2014SMART 2012\u20132016","volume":"37","author":"Lob","year":"2018","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B9","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.bjid.2017.03.006","article-title":"Resistance among Gram-negative ESKAPE pathogens isolated from hospitalized patients with intra-abdominal and urinary tract infections in Latin American countries: SMART 2013\u20132015","volume":"21","author":"Karlowsky","year":"2017","journal-title":"Braz J Infect Dis"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B10","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1093\/cid\/cix034","article-title":"The use of non-carbapenem \u03b2-lactams for the treatment of extended-spectrum \u03b2-lactamase infections","volume":"64","author":"Tamma","year":"2017","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B11","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1469-0691.2011.03703.x","article-title":"EUCAST expert rules in antimicrobial susceptibility testing","volume":"19","author":"Leclercq","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/jac\/dkv362","article-title":"Impact of the MIC of piperacillin\/tazobactam on the outcome for patients with bacteraemia due to Enterobacteriaceae: the bacteraemia\u2013MIC project","volume":"71","author":"Delgado-Valverde","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B13","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1128\/AAC.00135-13","article-title":"Impact of the MIC of piperacillin-tazobactam on the outcome of patients with bacteremia due to extended-spectrum-\u03b2-lactamase-producing Escherichia coli","volume":"57","author":"Retamar","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B14","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1001\/jama.2018.12163","article-title":"Effect of piperacillin-tazobactam vs meropenem on 30-day mortality for patients with E coli or Klebsiella pneumoniae bloodstream infection and ceftriaxone resistance: a randomized clinical trial","volume":"320","author":"Harris","year":"2018","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B15","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/jac\/dkg114","article-title":"Variable susceptibility to piperacillin\/tazobactam amongst Klebsiella spp. with extended-spectrum \u03b2-lactamases","volume":"51","author":"Babini","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B16","doi-asserted-by":"crossref","first-page":"e91800","DOI":"10.1371\/journal.pone.0091800","article-title":"Detection of OXA-1 \u03b2-lactamase gene of Klebsiella pneumoniae from blood stream infections (BSI) by conventional PCR and in-silico analysis to understand the mechanism of OXA mediated resistance","volume":"9","author":"Sugumar","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B17","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/BF01645578","article-title":"Comparative in vitro activities of amoxicillin-clavulanate, ampicillin-sulbactam and piperacillin-tazobactam against strains of Escherichia coli and Proteus mirabilis harbouring known \u03b2-lactamases","volume":"19","author":"Gatermann","year":"1991","journal-title":"Infection"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B18","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1128\/JCM.34.2.358-363.1996","article-title":"Hospital outbreak of Klebsiella pneumoniae resistant to broad-spectrum cephalosporins and \u03b2-lactam-\u03b2-lactamase inhibitor combinations by hyperproduction of SHV-5 \u03b2-lactamase","volume":"34","author":"French","year":"1996","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1093\/jac\/31.suppl_A.9","article-title":"Determinants of the activity of \u03b2-lactamase inhibitor combinations","volume":"31","author":"Livermore","year":"1993","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B20","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1128\/AAC.44.2.362-367.2000","article-title":"High-level expression of chromosomally encoded SHV-1 \u03b2-lactamase and an outer membrane protein change confer resistance to ceftazidime and piperacillin-tazobactam in a clinical isolate of Klebsiella pneumoniae","volume":"44","author":"Rice","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B21","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/jac\/dki412","article-title":"Multiplex PCR for rapid detection of genes encoding CTX-M extended-spectrum \u03b2-lactamases","volume":"57","author":"Woodford","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B22","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1128\/JCM.01943-07","article-title":"Molecular epidemiology of extended-spectrum \u03b2-lactamases among Escherichia coli isolates collected in a Swedish hospital and its associated health care facilities from 2001 to 2006","volume":"46","author":"Fang","year":"2008","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B23","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/BF01967473","article-title":"Detection of extended broad-spectrum \u03b2-lactamases in Enterobacteriaceae in four French hospitals","volume":"8","author":"Legrand","year":"1989","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B24","first-page":"1","article-title":"Working Party on Antibiotic Sensitivity Testing of the British Society for Antimicrobial Chemotherapy. A guide to sensitivity testing","volume":"27","year":"1991","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B25","author":"VelvetOptimiser"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B26","doi-asserted-by":"crossref","first-page":"e2308.","DOI":"10.7717\/peerj.2308","article-title":"MOST: a modified MLST typing tool based on short read sequencing","volume":"4","author":"Tewolde","year":"2016","journal-title":"Peer J"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B27","doi-asserted-by":"crossref","first-page":"3348","DOI":"10.1128\/AAC.00419-13","article-title":"The comprehensive antibiotic resistance database","volume":"57","author":"McArthur","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B28","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1128\/CMR.00125-13","article-title":"Escherichia coli ST131, an intriguing clonal group","volume":"27","author":"Nicolas-Chanoine","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B29","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1093\/jac\/dkx146","article-title":"Global epidemiology of CTX-M \u03b2-lactamases: temporal and geographical shifts in genotype","volume":"72","author":"Bevan","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B30","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1128\/AAC.02930-15","article-title":"Network analysis of sequence-function relationships and exploration of sequence space of TEM \u03b2-lactamases","volume":"60","author":"Zeil","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B31","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1128\/AAC.45.6.1615-1620.2001","article-title":"Oxacillinase-mediated resistance to cefepime and susceptibility to ceftazidime in Pseudomonas aeruginosa","volume":"45","author":"Aubert","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1089\/mdr.2015.0122","article-title":"Reduced susceptibility to cefepime in clinical isolates of Enterobacteriaceae producing OXA-1 \u03b2-lactamase","volume":"22","author":"Torres","year":"2016","journal-title":"Microb Drug Resist"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1093\/jac\/dkx360","article-title":"Potential of high-dose cefepime\/tazobactam against multiresistant Gram-negative pathogens","volume":"73","author":"Livermore","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B34","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/jac\/dkh424","article-title":"Community and hospital spread of Escherichia coli producing CTX-M extended-spectrum \u03b2-lactamases in the UK","volume":"54","author":"Woodford","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B35","doi-asserted-by":"crossref","first-page":"4472","DOI":"10.1128\/AAC.00688-09","article-title":"Complete nucleotide sequences of plasmids pEK204, pEK499, and pEK516, encoding CTX-M enzymes in three major Escherichia coli lineages from the United Kingdom, all belonging to the international O25:H4-ST131 clone","volume":"53","author":"Woodford","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B36","doi-asserted-by":"crossref","first-page":"3758","DOI":"10.1128\/AAC.48.10.3758-3764.2004","article-title":"Complete nucleotide sequence of a 92-kilobase plasmid harboring the CTX-M-15 extended-spectrum \u03b2-lactamase involved in an outbreak in long-term-care facilities in Toronto, Canada","volume":"48","author":"Boyd","year":"2004","journal-title":"Antimicrob Agent Chemother"},{"key":"key\n\t\t\t\t2019012509364548400_dky453-B37","doi-asserted-by":"crossref","DOI":"10.1093\/jac\/dky419","article-title":"Evaluation of multiplex tandem PCR (MT-PCR) assays for the detection of bacterial resistance genes among Enterobacteriaceae in clinical urines","volume":"74","author":"Schmidt","year":"2019","journal-title":"J Antimicrob Chemother"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/74\/2\/326\/27524706\/dky453.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T19:36:17Z","timestamp":1662233777000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/74\/2\/326\/5156209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,2]]},"references-count":37,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,11,2]]},"published-print":{"date-parts":[[2019,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dky453","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,2]]},"published":{"date-parts":[[2018,11,2]]}}}