{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:35:57Z","timestamp":1783132557922,"version":"3.54.6"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100006251","name":"University of Bordeaux","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006251","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"DOI":"10.1093\/jac\/dky475","type":"journal-article","created":{"date-parts":[[2018,10,25]],"date-time":"2018-10-25T01:48:02Z","timestamp":1540432082000},"page":"618-624","source":"Crossref","is-referenced-by-count":13,"title":["Challenging SNP impact on caspofungin resistance by full-length<i>FKS1<\/i>allele replacement in<i>Candida lusitaniae<\/i>"],"prefix":"10.1093","volume":"74","author":[{"given":"Isabelle","family":"Accoceberry","sequence":"first","affiliation":[{"name":"Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathog\u00e9nicit\u00e9, UMR 5234, Bordeaux, France"},{"name":"Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathog\u00e9nicit\u00e9, UMR 5234, CHU Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia","family":"Couzigou","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathog\u00e9nicit\u00e9, UMR 5234, Bordeaux, France"},{"name":"Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathog\u00e9nicit\u00e9, UMR 5234, CHU Bordeaux, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Fitton-Ouhabi","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathog\u00e9nicit\u00e9, UMR 5234, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Biteau","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathog\u00e9nicit\u00e9, UMR 5234, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0320-1126","authenticated-orcid":false,"given":"Thierry","family":"No\u00ebl","sequence":"additional","affiliation":[{"name":"Univ. Bordeaux, CNRS, Microbiologie Fondamentale et Pathog\u00e9nicit\u00e9, UMR 5234, Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,4]]},"reference":[{"key":"key\n\t\t\t\t2019021508595830600_dky475-B1","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/S0140-6736(03)14472-8","article-title":"Echinocandin antifungal drugs","volume":"362","author":"Denning","year":"2003","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B2","doi-asserted-by":"crossref","first-page":"2471","DOI":"10.1128\/AAC.41.11.2471","article-title":"Identification of the FKS1 gene of Candida albicans as the essential target of 1,3-\u03b2-d-glucan synthase inhibitors","volume":"41","author":"Douglas","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B3","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.1128\/AAC.00813-12","article-title":"Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata: implications for echinocandin resistance","volume":"56","author":"Katiyar","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B4","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1080\/02681219780000961","article-title":"Lipopeptide inhibitors of fungal glucan synthase","volume":"35","author":"Kurtz","year":"1997","journal-title":"J Med Vet Mycol"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B5","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1111\/j.1365-2958.2007.05588.x","article-title":"The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans","volume":"63","author":"Munro","year":"2007","journal-title":"Mol Microbiol"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B6","doi-asserted-by":"crossref","first-page":"13731","DOI":"10.1039\/C7NR02170D","article-title":"AFM combined to ATR-FTIR reveals Candida cell wall changes under caspofungin treatment","volume":"9","author":"Quil\u00e8s","year":"2017","journal-title":"Nanoscale"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/nyas.12831","article-title":"Mechanisms of echinocandin antifungal drug resistance: mechanism of echinocandin drug resistance","volume":"1354","author":"Perlin","year":"2015","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B8","doi-asserted-by":"crossref","first-page":"3264","DOI":"10.1128\/AAC.49.8.3264-3273.2005","article-title":"Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates","volume":"49","author":"Park","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B9","doi-asserted-by":"crossref","first-page":"3774","DOI":"10.1128\/AAC.01811-10","article-title":"New Fks hot spot for acquired echinocandin resistance in Saccharomyces cerevisiae and its contribution to intrinsic resistance of Scedosporium species","volume":"55","author":"Johnson","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B10","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1128\/AAC.00262-08","article-title":"A naturally occurring proline-to-alanine amino acid change in Fks1p in Candida parapsilosis, Candida orthopsilosis, and Candida metapsilosis accounts for reduced echinocandin susceptibility","volume":"52","author":"Garcia-Effron","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B11","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1128\/AAC.00020-09","article-title":"Role for Fks1 in the intrinsic echinocandin resistance of Fusarium solani as evidenced by hybrid expression in Saccharomyces cerevisiae","volume":"53","author":"Katiyar","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B12","doi-asserted-by":"crossref","first-page":"7715","DOI":"10.1128\/AAC.02204-15","article-title":"Acquired multidrug antifungal resistance in Candida lusitaniae during therapy","volume":"59","author":"Asner","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B13","doi-asserted-by":"crossref","first-page":"e02644","DOI":"10.1128\/AAC.02644-16","article-title":"Molecular confirmation of the relationship between Candida guilliermondii Fks1p naturally occurring amino acid substitutions and its intrinsic reduced echinocandin susceptibility","volume":"61","author":"Dudiuk","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/yea.1836","article-title":"A two-step cloning-free PCR-based method for the deletion of genes in the opportunistic pathogenic yeast Candida lusitaniae","volume":"28","author":"El-Kirat-Chatel","year":"2011","journal-title":"Yeast"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B15","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/yea.1059","article-title":"Development of an integrative transformation system for the opportunistic pathogenic yeast Candida lusitaniae using URA3 as a selection marker","volume":"21","author":"Fran\u00e7ois","year":"2004","journal-title":"Yeast"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B16","doi-asserted-by":"crossref","first-page":"e01483","DOI":"10.1128\/AAC.01483-17","article-title":"A CTG clade Candida yeast genetically engineered for the genotype-phenotype characterization of azole antifungal resistance in human-pathogenic yeasts","volume":"62","author":"Accoceberry","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B17","doi-asserted-by":"crossref","first-page":"e00724","DOI":"10.1128\/genomeA.00724-17","article-title":"Genome sequence of the yeast Clavispora lusitaniae type strain CBS 6936","volume":"5","author":"Durrens","year":"2017","journal-title":"Genome Announc"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B18","doi-asserted-by":"crossref","first-page":"4476","DOI":"10.1128\/AAC.00009-14","article-title":"Deletion of the uracil permease gene confers cross-resistance to 5-fluorouracil and azoles in Candida lusitaniae and highlights antagonistic interaction between fluorinated nucleotides and fluconazole","volume":"58","author":"Gabriel","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B19","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts\u2014Third Edition: Approved Standard M27-A3","year":"2008"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B20","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1002\/(SICI)1097-0061(199611)12:14<1439::AID-YEA37>3.0.CO;2-O","article-title":"New vectors for combinatorial deletions in yeast chromosomes and for gap-repair cloning using \u2018split-marker\u2019 recombination","volume":"12","author":"Fairhead","year":"1996","journal-title":"Yeast"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B21","doi-asserted-by":"crossref","first-page":"2973","DOI":"10.1099\/00221287-139-12-2973","article-title":"Calcineurin-dependent growth of an FK506- and CsA-hypersensitive mutant of Saccharomyces cevevisiae","volume":"139","author":"Parent","year":"1993","journal-title":"J Gen Microbiol"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B22","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1093\/jac\/dks112","article-title":"Reconstitution of high-level micafungin resistance detected in a clinical isolate of Candida glabrata identifies functional homozygosity in glucan synthase gene expression","volume":"67","author":"Niimi","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B23","doi-asserted-by":"crossref","first-page":"11128","DOI":"10.1038\/ncomms11128","article-title":"Prevalent mutator genotype identified in fungal pathogen Candida glabrata promotes multi-drug resistance","volume":"7","author":"Healey","year":"2016","journal-title":"Nat Commun"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B24","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1128\/jb.179.13.4096-4105.1997","article-title":"Cloning of the Candida albicans homolog of Saccharomyces cerevisiae GSC1\/FKS1 and its involvement in \u03b2-1,3-glucan synthesis","volume":"179","author":"Mio","year":"1997","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B25","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1128\/JCM.01901-07","article-title":"In vitro susceptibility of invasive isolates of Candida spp. to anidulafungin, caspofungin, and micafungin: six years of global surveillance","volume":"46","author":"Pfaller","year":"2008","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B26","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1128\/JCM.01590-09","article-title":"Wild-type MIC distributions and epidemiological cutoff values for the echinocandins and Candida spp","volume":"48","author":"Pfaller","year":"2010","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B27","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.diagmicrobio.2015.08.012","article-title":"Candida lusitaniae MICs to the echinocandins are elevated but FKS-mediated resistance is rare","volume":"84","author":"Lockhart","year":"2016","journal-title":"Diagn Microbiol Infect Dis"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B28","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1128\/AAC.00443-09","article-title":"Effect of Candida glabrata FKS1 and FKS2 mutations on echinocandin sensitivity and kinetics of 1,3-\u03b2-d-glucan synthase: implication for the existing susceptibility breakpoint","volume":"53","author":"Garcia-Effron","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B29","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1128\/AAC.01162-08","article-title":"Correlating echinocandin MIC and kinetic inhibition of fks1 mutant glucan synthases for Candida albicans: implications for interpretive breakpoints","volume":"53","author":"Garcia-Effron","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019021508595830600_dky475-B30","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/BF00443285","article-title":"Clavispora, a new yeast genus of the Saccharomycetales","volume":"45","author":"Rodrigues de Miranda","year":"1979","journal-title":"Antonie Van Leeuwenhoek"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/74\/3\/618\/27785948\/dky475.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,4]],"date-time":"2022-09-04T16:20:38Z","timestamp":1662308438000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/74\/3\/618\/5230873"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,4]]},"references-count":30,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,12,4]]},"published-print":{"date-parts":[[2019,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dky475","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,3]]},"published":{"date-parts":[[2018,12,4]]}}}