{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:36:06Z","timestamp":1792506966511,"version":"4.5.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T00:00:00Z","timestamp":1543536000000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"CANWARD"},{"DOI":"10.13039\/100004324","name":"Astellas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004324","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004334","name":"Merck","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009655","name":"Sunovion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015237","name":"The Medicines Company","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015237","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100001316","name":"Abbott","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Achaogen"},{"name":"Cubist"},{"name":"Paladin Labs"},{"DOI":"10.13039\/100004326","name":"Bayer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004326","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Janssen Ortho"},{"name":"Ortho McNeil"},{"name":"Affinium"},{"name":"Basilea"},{"DOI":"10.13039\/100004325","name":"AstraZeneca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004325","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Paratek"},{"name":"Tetraphase"},{"name":"Theravance"},{"DOI":"10.13039\/100004339","name":"Sanofi-Aventis","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004339","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100012895","name":"Zoetis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"DOI":"10.1093\/jac\/dky477","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T07:01:14Z","timestamp":1540364474000},"page":"645-653","source":"Crossref","is-referenced-by-count":31,"title":["Antimicrobial-resistant pathogens in Canadian ICUs: results of the CANWARD 2007 to 2016 study"],"prefix":"10.1093","volume":"74","author":[{"given":"Andrew J","family":"Denisuik","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren A","family":"Garbutt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa R","family":"Golden","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Clinical Microbiology, Shared Health Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Baxter","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A","family":"Nichol","sequence":"additional","affiliation":[{"name":"Clinical Microbiology, Shared Health Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lagac\u00e9-Wiens","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Clinical Microbiology, Shared Health Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Walkty","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Clinical Microbiology, Shared Health Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A","family":"Karlowsky","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Clinical Microbiology, Shared Health Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daryl J","family":"Hoban","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Mulvey","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Antimicrobial Resistance Branch, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George G","family":"Zhanel","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"key\n\t\t\t\t2019021507301429400_dky477-B1","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.idc.2016.04.012","article-title":"Antimicrobial stewardship for the infection control practitioner","volume":"30","author":"Nagel","year":"2016","journal-title":"Infect Dis Clin North Am"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B2","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.nmni.2015.02.007","article-title":"The global threat of antimicrobial resistance: science for intervention","volume":"6","author":"Roca","year":"2015","journal-title":"New Microbes New Infect"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B3","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1086\/499406","article-title":"The relationship between antimicrobial resistance and patient outcomes: mortality, length of hospital stay, and health care costs","volume":"42","author":"Cosgrove","year":"2006","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B4","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/01.CCM.0000114816.62331.08","article-title":"Use of intensive care at the end of life in the United States: an epidemiologic study","volume":"32","author":"Angus","year":"2004","journal-title":"Crit Care Med"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B5","doi-asserted-by":"crossref","first-page":"2323.","DOI":"10.1001\/jama.2009.1754","article-title":"International study of the prevalence and outcomes of infection in intensive care units","volume":"302","author":"Vincent","year":"2009","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B6","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1097\/CCM.0b013e31823c8d03","article-title":"A comparison of critical care research funding and the financial burden of critical illness in the United States","volume":"40","author":"Coopersmith","year":"2012","journal-title":"Crit Care Med"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B7","doi-asserted-by":"crossref","first-page":"133.","DOI":"10.1186\/s13054-016-1285-6","article-title":"Advances in antibiotic therapy in the critically ill","volume":"20","author":"Vincent","year":"2016","journal-title":"Crit Care"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B8","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1097\/01.CCM.0000217961.75225.E9","article-title":"Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock","volume":"34","author":"Kumar","year":"2006","journal-title":"Crit Care Med"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B9","doi-asserted-by":"crossref","first-page":"596.","DOI":"10.1186\/s13054-014-0596-8","article-title":"Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study","volume":"18","author":"Zilberberg","year":"2014","journal-title":"Crit Care"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B10","doi-asserted-by":"crossref","first-page":"i7","DOI":"10.1093\/jac\/dkt022","article-title":"Antimicrobial susceptibility of 22746 pathogens from Canadian hospitals: results of the CANWARD 2007-11 study","volume":"68","author":"Zhanel","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B11","volume-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically\u2014Tenth Edition: Approved Standard M07-A10","year":"2015"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B12","volume-title":"Performance Standards for Antimicrobial Susceptibility Testing: Twenty-seventh Informational Supplement M100-S27","year":"2017"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B13","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1469-0691.2011.03570.x","article-title":"Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance","volume":"18","author":"Magiorakos","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B14","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1093\/jac\/dkv107","article-title":"Characterization of MDR and XDR Streptococcus pneumoniae in Canada, 2007-13","volume":"70","author":"Golden","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B15","doi-asserted-by":"crossref","first-page":"i47","DOI":"10.1093\/jac\/dkt026","article-title":"Changing epidemiology of methicillin-resistant Staphylococcus aureus in Canada","volume":"68","author":"Nichol","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B16","doi-asserted-by":"crossref","first-page":"i57","DOI":"10.1093\/jac\/dkt027","article-title":"Molecular epidemiology of extended-spectrum \u03b2-lactamase-, AmpC \u03b2-lactamase- and carbapenemase-producing Escherichia coli and Klebsiella pneumoniae isolated from Canadian hospitals over a 5 year period: CANWARD 2007-11","volume":"68","author":"Denisuik","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B17","doi-asserted-by":"crossref","first-page":"4684","DOI":"10.1128\/AAC.00469-10","article-title":"Prevalence of antimicrobial-resistant pathogens in Canadian hospitals: results of the Canadian Ward Surveillance study (CANWARD 2008)","volume":"54","author":"Zhanel","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B18","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.diagmicrobio.2006.12.022","article-title":"Antimicrobial resistance and molecular epidemiology of vancomycin-resistant enterococci from North America and Europe: a report from the SENTRY antimicrobial surveillance program","volume":"58","author":"Deshpande","year":"2007","journal-title":"Diagn Microbiol Infect Dis"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B19","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1128\/AAC.01538-07","article-title":"Antimicrobial-resistant pathogens in intensive care units in Canada: results of the Canadian National Intensive Care Unit (CAN-ICU) study, 2005-2006","volume":"52","author":"Zhanel","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B20","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1136\/thoraxjnl-2015-207688","article-title":"Increasing burden of community-acquired pneumonia leading to hospitalisation, 1998\u20132014","volume":"71","author":"Quan","year":"2016","journal-title":"Thorax"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B21","doi-asserted-by":"crossref","first-page":"S1.","DOI":"10.1186\/cc4927","article-title":"Community-acquired pneumonia on the intensive care unit: secondary analysis of 17,869 cases in the ICNARC Case Mix Programme Database","volume":"10","author":"Woodhead","year":"2006","journal-title":"Crit Care"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ijantimicag.2003.12.019","article-title":"Assessment of pathogen occurrences and resistance profiles among infected patients in the intensive care unit: report from the SENTRY Antimicrobial Surveillance Program (North America, 2001)","volume":"24","author":"Streit","year":"2004","journal-title":"Int J Antimicrob Agents"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/CCM.0b013e31819285f0","article-title":"A prospective, observational registry of patients with severe sepsis: the Canadian Sepsis Treatment and Response Registry","volume":"37","author":"Martin","year":"2009","journal-title":"Crit Care Med"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B24","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.diagmicrobio.2010.10.026","article-title":"Prevalence of antimicrobial resistant pathogens from blood cultures from Canadian hospitals: results of the CANWARD 2007-2009 study","volume":"69","author":"Adam","year":"2011","journal-title":"Diagn Microbiol Infect Dis"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B25","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.diagmicrobio.2013.11.025","article-title":"Antimicrobial susceptibility of Gram-negative organisms isolated from patients hospitalized in intensive care units in United States and European hospitals (2009-2011)","volume":"78","author":"Sader","year":"2014","journal-title":"Diagn Microbiol Infect Dis"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B26","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1001\/archsurg.133.10.1041","article-title":"Antibiotic susceptibility in the surgical intensive care unit compared with the hospital-wide antibiogram","volume":"133","author":"Kaufman","year":"1998","journal-title":"Arch Surg"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B27","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/jac\/dkh277","article-title":"Resistance rates of Staphylococcus aureus in relation to patient status and type of specimen","volume":"54","author":"Daxboeck","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B28","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s15010-010-0033-0","article-title":"Comparison of hospital-wide and unit-specific cumulative antibiograms in hospital- and community-acquired infection","volume":"38","author":"Lamoth","year":"2010","journal-title":"Infection"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B29","doi-asserted-by":"crossref","first-page":"i23","DOI":"10.1093\/jac\/dkt023","article-title":"Trends in antibiotic resistance over time among pathogens from Canadian hospitals: results of the CANWARD study 2007-11","volume":"68","author":"Lagac\u00e9-Wiens","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B30","first-page":"1571","article-title":"Universal glove and gown use and acquisition of antibiotic-resistant bacteria in the ICU: a randomized trial","volume":"310","author":"Harris","year":"2013","journal-title":"JAMA"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B31","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1093\/jac\/dks464","article-title":"National multidrug-resistant bacteria (MDRB) surveillance in France through the RAISIN network: a 9 year experience","volume":"68","author":"Carbonne","year":"2013","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B32","doi-asserted-by":"crossref","DOI":"10.1177\/2054270414547145","article-title":"Hospital-wide infection control practice and meticillin-resistant Staphylococcus aureus (MRSA) in the intensive care unit (ICU): an observational study","volume":"5","author":"Thompson","year":"2014","journal-title":"JRSM Open"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B33","doi-asserted-by":"crossref","first-page":"e58112.","DOI":"10.1371\/journal.pone.0058112","article-title":"Do active surveillance and contact precautions reduce MRSA acquisition? A prospective interrupted time series","volume":"8","author":"Marshall","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B34","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1086\/528716","article-title":"Are community-associated methicillin-resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains?","volume":"46","author":"Popovich","year":"2008","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B35","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1086\/499815","article-title":"Emergence of community-associated methicillin-resistant Staphylococcus aureus USA300 genotype as a major cause of health care-associated blood stream infections","volume":"42","author":"Seybold","year":"2006","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B36","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1086\/668433","article-title":"Impact of vancomycin minimum inhibitory concentration on mortality among critically ill patients with methicillin-resistant Staphylococcus aureus bacteremia","volume":"33","author":"Woods","year":"2012","journal-title":"Infect Control Hosp Epidemiol"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B37","doi-asserted-by":"crossref","first-page":"3352","DOI":"10.1128\/JCM.01284-07","article-title":"Antimicrobial resistance among Gram-negative bacilli causing infections in intensive care unit patients in the United States between 1993 and 2004","volume":"45","author":"Lockhart","year":"2007","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/668770","article-title":"Antimicrobial-resistant pathogens associated with healthcare-associated infections: summary of data reported to the National Healthcare Safety Network at the Centers for Disease Control and Prevention, 2009\u20132010","volume":"34","author":"Sievert","year":"2013","journal-title":"Infect Control Hosp Epidemiol"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B39","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.diagmicrobio.2012.05.024","article-title":"Antimicrobial susceptibility of Enterobacteriaceae, including molecular characterization of extended-spectrum \u03b2-lactamase-producing species, in urinary tract isolates from hospitalized patients in North America and Europe: results from the SMART study","volume":"74","author":"Hoban","year":"2012","journal-title":"Diagn Microbiol Infect Dis"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B40","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/jac\/dks046","article-title":"Carbapenem-resistant Gram-negative bacilli in Canada 2009-10: results from the Canadian nosocomial infection surveillance program (CNISP)","volume":"67","author":"Mataseje","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B41","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1128\/JCM.02289-15","article-title":"Epidemiologic and genotypic review of carbapenemase-producing organisms in British Columbia, Canada, between 2008 and 2014","volume":"54","author":"Sekirov","year":"2016","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B42","doi-asserted-by":"crossref","first-page":"e0125076","DOI":"10.1371\/journal.pone.0125076","article-title":"Carbapenem non-susceptible Enterobacteriaceae in Quebec, Canada: results of a laboratory surveillance program (2010-2012)","volume":"10","author":"Lefebvre","year":"2015","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B43","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1093\/jac\/dku040","article-title":"Serratia marcescens harbouring SME-type class A carbapenemases in Canada and the presence of blaSME on a novel genomic island, SmarGI1-1","volume":"69","author":"Mataseje","year":"2014","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B44","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1503\/cmaj.111100","article-title":"New Delhi metallo-\u03b2-lactamase-1: detection and prevention","volume":"183","author":"Walsh","year":"2011","journal-title":"CMAJ"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B45","doi-asserted-by":"crossref","first-page":"e109","DOI":"10.1093\/cid\/cis737","article-title":"Outbreak of carbapenem-resistant Enterobacteriaceae containing blaNDM-1, Ontario, Canada","volume":"55","author":"Borgia","year":"2012","journal-title":"Clin Infect Dis"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B46","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.diagmicrobio.2015.01.005","article-title":"Isolation of multiple carbapenemase-producing Gram-negative bacilli from a patient recently hospitalized in Nigeria","volume":"81","author":"Walkty","year":"2015","journal-title":"Diagn Microbiol Infect Dis"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B47","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/S1473-3099(14)70036-2","article-title":"Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions","volume":"14","author":"Roberts","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"key\n\t\t\t\t2019021507301429400_dky477-B48","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1093\/cid\/ciu027","article-title":"DALI: defining antibiotic levels in intensive care unit patients: are current \u03b2-lactam antibiotic doses sufficient for critically ill patients?","volume":"58","author":"Roberts","year":"2014","journal-title":"Clin Infect Dis"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/74\/3\/645\/27785313\/dky477.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T08:33:14Z","timestamp":1589963594000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/74\/3\/645\/5219007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,29]]},"references-count":48,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,11,29]]},"published-print":{"date-parts":[[2019,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dky477","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,3]]},"published":{"date-parts":[[2018,11,29]]}}}