{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:28:38Z","timestamp":1787063318384,"version":"build-2736575974"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T00:00:00Z","timestamp":1548028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Fondo di Ataneo per la Ricerca","award":["FAR 2017"],"award-info":[{"award-number":["FAR 2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"DOI":"10.1093\/jac\/dky510","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T22:28:51Z","timestamp":1546986531000},"page":"1069-1077","source":"Crossref","is-referenced-by-count":41,"title":["Bovine lactoferrin enhances the efficacy of levofloxacin-based triple therapy as first-line treatment of\n                    <i>Helicobacter pylori<\/i>\n                    infection: an\n                    <i>in vitro<\/i>\n                    and\n                    <i>in vivo<\/i>\n                    study"],"prefix":"10.1093","volume":"74","author":[{"given":"Antonio Francesco","family":"Ciccaglione","sequence":"first","affiliation":[{"name":"Digestive Sciences Unit, \u2018G. d\u2019Annunzio\u2019 University, Pescara Civic Hospital, Via Fonte Romana 8, Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Di Giulio","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \u2018G. d\u2019Annunzio\u2019 University, Via dei Vestini, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Di Lodovico","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \u2018G. d\u2019Annunzio\u2019 University, Via dei Vestini, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Di Campli","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \u2018G. d\u2019Annunzio\u2019 University, Via dei Vestini, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4068-9124","authenticated-orcid":false,"given":"Luigina","family":"Cellini","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, \u2018G. d\u2019Annunzio\u2019 University, Via dei Vestini, Chieti, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Marzio","sequence":"additional","affiliation":[{"name":"Digestive Sciences Unit, \u2018G. d\u2019Annunzio\u2019 University, Pescara Civic Hospital, Via Fonte Romana 8, Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,1,21]]},"reference":[{"key":"key\n\t\t\t\t2019031509373989600_dky510-B1","first-page":"CD003840","article-title":"Eradication therapy for peptic ulcer disease in Helicobacter pylori-positive people","author":"Ford","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B2","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1182\/asheducation-2013.1.109","article-title":"Helicobacter pylori and mucosa-associated lymphoid tissue: what\u2019s new","volume":"2013","author":"Kuo","year":"2013","journal-title":"Hematol Soc Hematol Educ Program"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000357858","article-title":"Helicobacter pylori and gastric cancer","volume":"32","author":"Bornschein","year":"2014","journal-title":"Dig Dis"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B4","first-page":"112","article-title":"Helicobacter pylori infection: old and new","volume":"10","author":"Diaconu","year":"2017","journal-title":"J Med Life"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B5","first-page":"373","article-title":"First-line therapies for Helicobacter pylori eradication: a critical reappraisal of updated guidelines","volume":"30","author":"De Francesco","year":"2017","journal-title":"Ann Gastroenterol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B6","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1038\/ajg.2008.91","article-title":"H. pylori treatment: new wine in old bottles?","volume":"104","author":"Vakil","year":"2009","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B7","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4172\/2332-0877.1000292","article-title":"Novel strategies to combat antimicrobial resistance","volume":"4","author":"Kaur","year":"2016","journal-title":"J Infect Dis Ther"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B8","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1111\/jgh.12984","article-title":"Sequential or concomitant therapy for eradication of Helicobacter pylori infection: a systematic review and meta-analysis","volume":"30","author":"Kim","year":"2015","journal-title":"J Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B9","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1046\/j.1365-2036.1999.00552.x","article-title":"Two-week dual vs. one-week triple therapy for cure for Helicobacter pylori infection in primary care: a multicentre, randomized trial","volume":"13","author":"Calvet","year":"1999","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1136\/gutjnl-2016-312288","article-title":"Management of Helicobacter pylori infection\u2014the Maastricht V\/Florence Consensus Report","volume":"66","author":"Malfertheiner","year":"2017","journal-title":"Gut"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B11","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1046\/j.1523-5378.2002.00096.x","article-title":"The relationship between consumption of antimicrobial agents and the prevalence of primary Helicobacter pylori resistance","volume":"7","author":"Perez Aldana","year":"2002","journal-title":"Helicobacter"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B12","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1136\/gutjnl-2012-302254","article-title":"Helicobacter pylori resistance to antibiotics in Europe and its relationship to antibiotic consumption","volume":"62","author":"Megraud","year":"2013","journal-title":"Gut"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B13","first-page":"409","article-title":"Worldwide H. pylori antibiotic resistance: a systematic review","volume":"19","author":"De Francesco","year":"2010","journal-title":"J Gastrointestin Liver Dis"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B14","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1136\/gut.2003.022111","article-title":"pylori antibiotic resistance: prevalence, importance and advances in testing","volume":"53","author":"Megraud","year":"2004","journal-title":"Gut"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B15","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1586\/eri.09.113","article-title":"Geographic map and evolution of primary Helicobacter pylori resistance to antibacterial agents","volume":"8","author":"Boyanova","year":"2010","journal-title":"Expert Rev Anti Infect Ther"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B16","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3109\/00365521.2015.1092577","article-title":"In vitro antimicrobial susceptibility of Helicobacter pylori to nine antibiotics currently used in Central Italy","volume":"3","author":"Di Giulio","year":"2016","journal-title":"Scand J Gastroenterol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B17","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1136\/gut.45.2008.i40","article-title":"Treatment after failure. The problem of \u2018non-responders\u2019","volume":"45","author":"Huang","year":"1999","journal-title":"Gut"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B18","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1093\/jac\/dks209","article-title":"Levofloxacin versus clarithromycin in a 10 day triple therapy regimen for first-line Helicobacter pylori eradication: a single-blind randomized clinical trial","volume":"67","author":"Cuadrado-Lav\u00edn","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B19","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1523-5378.2009.00722.x","article-title":"Clarithromycin amoxycillin-containing triple therapy: a valid empirical first-line treatment for Helicobacter pylori eradication in Hong Kong?","volume":"14","author":"Hung","year":"2009","journal-title":"Helicobacter"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B20","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1111\/j.1365-2036.2010.04274.x","article-title":"Clinical trial: clarithromycin vs. LEV in first-line triple and sequential regimens for Helicobacter pylori eradication","volume":"31","author":"Molina-Infante","year":"2010","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B21","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.dld.2005.03.007","article-title":"One-week once-daily triple therapy with esomeprazole, LEV and azithromycin compared to a standard therapy for Helicobacter pylori eradication","volume":"37","author":"Iacopini","year":"2005","journal-title":"Dig Liver Dis"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B22","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0140-6736(11)60020-2","article-title":"Helicobacter pylori eradication with a capsule containing bismuth citrate potassium, metronidazole, and tetracycline given with omeprazole versus clarithromycin-based triple therapy: a randomized, open-label, non inferiority phase 3 trial","volume":"377","author":"Malfertheiner","year":"2011","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B23","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/hel.12209","article-title":"A triple and quadruple therapy with doxycycline and bismuth for first-line treatment of Helicobacter pylori infection: a pilot study","volume":"20","author":"Ciccaglione","year":"2015","journal-title":"Helicobacter"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B24","doi-asserted-by":"crossref","first-page":"724","DOI":"10.3748\/wjg.v20.i3.724","article-title":"Efficacy of fermented milk and whey proteins in Helicobacter pylori eradication: a review","volume":"20","author":"Sachdeva","year":"2014","journal-title":"World J Gastroenterol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B25","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.biochi.2008.05.015","article-title":"Antimicrobial properties of lactoferrin","volume":"91","author":"Jenssen","year":"2009","journal-title":"Biochimie"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B26","doi-asserted-by":"crossref","first-page":"2774","DOI":"10.1128\/IAI.56.11.2774-2781.1988","article-title":"Damage of the outer membrane of enteric Gram-negative bacteria by lactoferrin and transferrin","volume":"56","author":"Ellison","year":"1988","journal-title":"Infect Immun"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF02490180","article-title":"Antibacterial effects of lactoferrin and a pepsin-generated lactoferrin peptide against Helicobacter pylori in vitro","volume":"3","author":"Yamazaki","year":"1997","journal-title":"J Infect Chemother"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B28","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1080\/00365529950173627","article-title":"The therapeutic effect of bovine lactoferrin in the host infected with Helicobacter pylori","volume":"34","author":"Wada","year":"1999","journal-title":"Scand J Gastroenterol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B29","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s10156-005-0407-X","article-title":"Bovine lactoferrin is effective to suppress Helicobacter pylori colonization in the human stomach: a randomized, double-blind, placebo-controlled study","volume":"11","author":"Okuda","year":"2005","journal-title":"J Infect Chemother"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B30","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1046\/j.1365-2036.2003.01395.x","article-title":"Human recombinant lactoferrin is ineffective in the treatment of human Helicobacter pylori infection","volume":"17","author":"Guttner","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B31","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/00365520510024223","article-title":"Analysis of genetic variability, antimicrobial susceptibility and virulence markers in Helicobacter pylori identified in Central Italy","volume":"41","author":"Cellini","year":"2006","journal-title":"Scand J Gastroenterol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B32","first-page":"343","article-title":"A model of Helicobacter pylori persistence in a case of gastric cancer","volume":"33","author":"Grande","year":"2010","journal-title":"New Microbiol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B33","volume-title":"Methods for Antimicrobial Dilution and Disk Susceptibility Testing of Infrequently Isolated or Fastidious Bacteria\u2014Third Edition: M45","year":"2016"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fmicb.2015.00165","article-title":"Antimicrobial activity of essential oils and carvacrol, and synergy of carvacrol and erythromycin, against clinical, erythromycin-resistant Group A streptococci","volume":"6","author":"Magi","year":"2015","journal-title":"Front Microbiol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B35","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1574-695X.1996.tb00251.x","article-title":"Inhibition of Helicobacter pylori by garlic extract (Allium sativum)","volume":"13","author":"Cellini","year":"1996","journal-title":"FEMS Immunol Med Microbiol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B36","doi-asserted-by":"crossref","first-page":"1.","DOI":"10.1093\/jac\/dkg301","article-title":"Synergy, antagonism, and what the chequerboard puts between them","volume":"52","author":"Odds","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B37","doi-asserted-by":"crossref","first-page":"7234","DOI":"10.1128\/JB.00626-07","article-title":"Transcriptional regulation of stress response and motility functions in Helicobacter pylori is mediated by HspR and HrcA","volume":"189","author":"Roncarati","year":"2007","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B38","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1128\/JB.01332-13","article-title":"Requirement of the flagellar protein export apparatus component FliO for optimal expression of Flagellar Genes in Helicobacter pylori","volume":"15","author":"Tsang","year":"2014","journal-title":"J Bacteriol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B39","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cgh.2008.10.024","article-title":"Efficient identification and evaluation of effective Helicobacter pylori therapies","volume":"7","author":"Graham","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B40","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1023\/A:1026675916421","article-title":"Antibiotic properties of bovine lactoferrin on Helicobacter pylori","volume":"43","author":"Dial","year":"1998","journal-title":"Dig Dis Sci"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B41","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1002\/ptr.5994","article-title":"Curcumin, an antibiotic resistance breaker against a multiresistant clinical isolate of Mycobacterium abscessus","volume":"32","author":"Marini","year":"2018","journal-title":"Phytother Res"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B42","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/nrd4675","article-title":"Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?","volume":"14","author":"Brown","year":"2015","journal-title":"Nat Rev Drug Discov"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B43","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1111\/j.1365-2036.2009.03934.x","article-title":"Meta-analysis: efficacy of bLF in Helicobacter pylori eradication","volume":"29","author":"Sachdeva","year":"2009","journal-title":"Aliment Pharmacol Ther"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B44","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/adc.67.5.657","article-title":"Biological role of lactoferrin","volume":"67","author":"Sanchez","year":"1992","journal-title":"Arch Dis Child"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B45","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0934-8840(11)80946-1","article-title":"Siderophore production and iron-regulated envelope proteins of Helicobacter pylori","volume":"280","author":"Illingworth","year":"1993","journal-title":"Zentralbl Bakteriol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B46","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/417552a","article-title":"A component of innate immunity prevents bacterial biofilm development","volume":"417","author":"Singh","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B47","doi-asserted-by":"crossref","first-page":"13391","DOI":"10.1016\/S0021-9258(18)90707-6","article-title":"The effect of human serum transferrin and milk lactoferrin on hydroxyl radical formation from superoxide and hydrogen peroxide","volume":"259","author":"Baldwin","year":"1984","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B48","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S1590-8658(03)00412-2","article-title":"Lactoferrin: milking ulcers?","volume":"35","author":"Borody","year":"2003","journal-title":"Dig Liver Dis"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B49","doi-asserted-by":"crossref","first-page":"2593","DOI":"10.1128\/JCM.34.10.2593-2594.1996","article-title":"Direct activity of recombinant, human lactoferrin against Helicobacter pylori","volume":"34","author":"Mielke","year":"1996","journal-title":"J Clin Microbiol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B50","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1211\/0022357001777595","article-title":"Recombinant human lactoferrin is effective in the treatment of Helicobacter felis-infected mice","volume":"52","author":"Dial","year":"2000","journal-title":"J Pharm Pharmacol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B51","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3892\/ijmm.2015.2251","article-title":"Recombinant human lactoferrin enhances the efficacy of triple therapy in mice infected with Helicobacter pylori","volume":"36","author":"Yuan","year":"2015","journal-title":"Int J Mol Med"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B52","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1111\/j.1572-0241.2006.00716.x","article-title":"LEV-based triple therapy in first-line treatment for Helicobacter pylori eradication","volume":"101","author":"Nista","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B53","doi-asserted-by":"crossref","first-page":"348","DOI":"10.5455\/medarh.2013.67.348-350","article-title":"The efficacy of LEV-based triple therapy first-line Helicobacter pylori eradication","volume":"67","author":"Telaku","year":"2013","journal-title":"Med Arch"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B54","doi-asserted-by":"crossref","first-page":"e85620.","DOI":"10.1371\/journal.pone.0085620","article-title":"LEV-based first-line therapy versus standard first-line therapy for Helicobacter pylori eradication: meta-analysis of randomized controlled trials","volume":"9","author":"Peedikayil","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B55","first-page":"467","article-title":"Helicobacter pylori isolates from proximal and distal stomach of patients never treated and already treated show genetic variability and discordant antibiotic resistance","volume":"23","author":"Marzio","year":"2011","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B56","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1111\/j.1572-0241.2007.01085.x","article-title":"Helicobacter pylori eradication: a randomized prospective study of triple therapy versus triple therapy plus lactoferrin and probiotics","volume":"102","author":"de Bortoli","year":"2007","journal-title":"Am J Gastroenterol"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B57","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/S1590-8658(03)00409-2","article-title":"Use of lactoferrin for Helicobacter pylori eradication","volume":"35","author":"Di Mario","year":"2003","journal-title":"Dig Liv Dis"},{"key":"key\n\t\t\t\t2019031509373989600_dky510-B58","doi-asserted-by":"crossref","first-page":"5385","DOI":"10.3748\/wjg.14.5385","article-title":"\u201cRescue\u201d regimens after Helicobacter pylori treatment failure","volume":"14","author":"Gisbert","year":"2008","journal-title":"World J Gastroenterol"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/74\/4\/1069\/28078169\/dky510.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,13]],"date-time":"2024-07-13T18:06:31Z","timestamp":1720893991000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/74\/4\/1069\/5298195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,21]]},"references-count":58,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,1,21]]},"published-print":{"date-parts":[[2019,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dky510","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4]]},"published":{"date-parts":[[2019,1,21]]}}}