{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T03:46:29Z","timestamp":1790135189988,"version":"4.0.1"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates foundation","doi-asserted-by":"crossref","award":["OPP1153928"],"award-info":[{"award-number":["OPP1153928"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"DOI":"10.1093\/jac\/dkz083","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T15:25:14Z","timestamp":1549639514000},"page":"1642-1647","source":"Crossref","is-referenced-by-count":39,"title":["Pharmacokinetics of ascending doses of ivermectin in Trichuris trichiura-infected children aged 2\u201312 years"],"prefix":"10.1093","volume":"74","author":[{"given":"Jessica D","family":"Schulz","sequence":"first","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland"},{"name":"University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean T","family":"Coulibaly","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland"},{"name":"University of Basel, Basel, Switzerland"},{"name":"Unit\u00e9 de Formation et de Recherche Biosciences, Universit\u00e9 F\u00e9lix Houphou\u00ebt\u2013Boigny, Abidjan, C\u00f4te d\u2019Ivoire"},{"name":"Centre Suisse de Recherches Scientifiques en C\u00f4te d\u2019Ivoire, Abidjan, C\u00f4te d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schindler","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland"},{"name":"University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wimmersberger","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland"},{"name":"University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland"},{"name":"University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,11]]},"reference":[{"key":"2019051708100713900_dkz083-B1","year":"2006"},{"key":"2019051708100713900_dkz083-B2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.pt.2014.07.005","article-title":"Ivermectin: panacea for resource-poor communities?","volume":"30","author":"Omura","year":"2014","journal-title":"Trends Parasitol"},{"key":"2019051708100713900_dkz083-B3","year":"2016"},{"key":"2019051708100713900_dkz083-B4","first-page":"317","article-title":"The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug","volume":"8","author":"Juarez","year":"2018","journal-title":"Am J Cancer Res"},{"key":"2019051708100713900_dkz083-B5","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S1473-3099(18)30163-4","article-title":"Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial","volume":"18","author":"Smit","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"2019051708100713900_dkz083-B6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0140-6736(17)31930-X","article-title":"Soil-transmitted helminth infections","volume":"391","author":"Jourdan","year":"2017","journal-title":"Lancet"},{"key":"2019051708100713900_dkz083-B7","year":"2017"},{"key":"2019051708100713900_dkz083-B8","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.pt.2018.04.008","article-title":"Preventive chemotherapy in the fight against soil-transmitted helminthiasis: achievements and limitations","volume":"34","author":"Schulz","year":"2018","journal-title":"Trends Parasitol"},{"key":"2019051708100713900_dkz083-B9","year":"2017"},{"key":"2019051708100713900_dkz083-B10","doi-asserted-by":"crossref","first-page":"j4307.","DOI":"10.1136\/bmj.j4307","article-title":"Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis","volume":"358","author":"Moser","year":"2017","journal-title":"BMJ"},{"key":"2019051708100713900_dkz083-B11","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1177\/009127002401382731","article-title":"Safety, tolerability, and pharmacokinetics of escalating high doses of ivermectin in healthy adult subjects","volume":"42","author":"Guzzo","year":"2002","journal-title":"J Clin Pharmacol"},{"key":"2019051708100713900_dkz083-B12","first-page":"79","article-title":"Ivermectin uptake and distribution in the plasma and tissue of Sudanese and Mexican patients infected with Onchocerca volvulus","volume":"42","author":"Elkassaby","year":"1991","journal-title":"Trop Med Parasitol"},{"key":"2019051708100713900_dkz083-B13","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/BF00637608","article-title":"The relative systemic availability of ivermectin after administration as capsule, tablet, and oral solution","volume":"35","author":"Edwards","year":"1988","journal-title":"Eur J Clin Pharmacol"},{"key":"2019051708100713900_dkz083-B14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1179\/000349803235001697","article-title":"The co-administration of ivermectin and albendazole\u2014safety, pharmacokinetics and efficacy against Onchocerca volvulus","volume":"97","author":"Awadzi","year":"2003","journal-title":"Ann Trop Med Parasitol"},{"key":"2019051708100713900_dkz083-B15","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.jpba.2005.08.026","article-title":"Liquid chromatographic assay of ivermectin in human plasma for application to clinical pharmacokinetic studies","volume":"40","author":"Kitzman","year":"2006","journal-title":"J Pharm Biomed Anal"},{"key":"2019051708100713900_dkz083-B16","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/cpt.1219","article-title":"Pharmacokinetics-pharmacodynamics of high-dose ivermectin with dihydroartemisinin-piperaquine on mosquitocidal activity and QT-prolongation (IVERMAL)","volume":"105","author":"Smit","year":"2018","journal-title":"Clin Pharmacol Ther"},{"key":"2019051708100713900_dkz083-B17","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s00228-010-0851-0","article-title":"A systematic review of pharmacokinetics studies in children with protein-energy malnutrition","volume":"66","author":"Oshikoya","year":"2010","journal-title":"Eur J Clin Pharmacol"},{"key":"2019051708100713900_dkz083-B18","doi-asserted-by":"crossref","first-page":"2901","DOI":"10.1039\/C8AY00828K","article-title":"Development and validation of a LC-MS\/MS method for ivermectin quantification in dried blood spots: application to a pharmacokinetic study in Trichuris trichiura-infected adults","volume":"10","author":"Schulz","year":"2018","journal-title":"Anal Methods"},{"key":"2019051708100713900_dkz083-B19","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/cid\/ciy246","article-title":"Efficacy and safety of ivermectin against Trichuris trichiura in preschool- and school-aged children: a randomized controlled dose-finding trial","volume":"67","author":"Wimmersberger","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2019051708100713900_dkz083-B20","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/1346-8138.13321","article-title":"Effect of high-fat meal intake on the pharmacokinetic profile of ivermectin in Japanese patients with scabies","volume":"43","author":"Miyajima","year":"2016","journal-title":"J Dermatol"},{"key":"2019051708100713900_dkz083-B21","year":"2013"},{"key":"2019051708100713900_dkz083-B22","doi-asserted-by":"crossref","first-page":"e00959","DOI":"10.1128\/AAC.00959-18","article-title":"Pharmacokinetics of a pediatric tribendimidine dose-finding study to treat hookworm infection in African children","volume":"62","author":"Hiroshige","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"2019051708100713900_dkz083-B23","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1517\/17425255.2012.698261","article-title":"Ontogeny of oral drug absorption processes in children","volume":"8","author":"Mooij","year":"2012","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"2019051708100713900_dkz083-B24","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ijpharm.2016.04.024","article-title":"Age-mediated changes in the gastrointestinal tract","volume":"512","author":"Merchant","year":"2016","journal-title":"Int J Pharm"},{"key":"2019051708100713900_dkz083-B25","first-page":"167","article-title":"Ivermectin pharmacokinetics","volume":"39","author":"Flajs","year":"2002","journal-title":"Slov Vet Res"},{"key":"2019051708100713900_dkz083-B26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/s11096-010-9455-0","article-title":"Review of paediatric gastrointestinal physiology data relevant to oral drug delivery","volume":"33","author":"Kaye","year":"2011","journal-title":"Int J Clin Pharm"},{"key":"2019051708100713900_dkz083-B27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1208\/s12248-007-9000-9","article-title":"The pharmacokinetics and interactions of ivermectin in humans\u2014a mini-review","volume":"10","author":"Gonz\u00e1lez Canga","year":"2008","journal-title":"AAPS J"},{"key":"2019051708100713900_dkz083-B28","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1016\/j.xphs.2018.03.026","article-title":"The repurposing of ivermectin for malaria: a prospective pharmacokinetics-based virtual clinical trials assessment of dosing regimen options","volume":"107","author":"Badhan","year":"2018","journal-title":"J Pharm Sci"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/74\/6\/1642\/28666518\/dkz083.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T08:10:29Z","timestamp":1558080629000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/74\/6\/1642\/5374738"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,11]]},"references-count":28,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,3,11]]},"published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkz083","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,6]]},"published":{"date-parts":[[2019,3,11]]}}}