{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T16:10:17Z","timestamp":1788451817590,"version":"build-2803163510"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T00:00:00Z","timestamp":1552348800000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Life Science Health Priority"},{"name":"7th Framework Program"},{"name":"Assessment of Clinical Efficacy by a Pharmacokinetic"},{"name":"Pharmacodynamic Approach to Optimize Effectiveness and Reduce Resistance for Off-Patent Antibiotics","award":["278348"],"award-info":[{"award-number":["278348"]}]},{"name":"Pharmacodynamic Approach to Optimize Effectiveness and Reduce Resistance for Off-Patent Antibiotics","award":["241796"],"award-info":[{"award-number":["241796"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,6,1]]},"DOI":"10.1093\/jac\/dkz095","type":"journal-article","created":{"date-parts":[[2019,2,19]],"date-time":"2019-02-19T07:14:58Z","timestamp":1550560498000},"page":"1656-1661","source":"Crossref","is-referenced-by-count":30,"title":["The pharmacokinetics of nitrofurantoin in healthy female volunteers: a randomized crossover study"],"prefix":"10.1093","volume":"74","author":[{"given":"Angela","family":"Huttner","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rixt A","family":"Wijma","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J","family":"Stewardson","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease, Alfred Health and Central Clinical School, Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flaminia","family":"Olearo","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Von Dach","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland"},{"name":"Clinical Trials Unit, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Harbarth","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland"},{"name":"Infection Control Program, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger J M","family":"Br\u00fcggemann","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Center of Expertise in Mycology, Radboud University, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan W","family":"Mouton","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anouk E","family":"Muller","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Infectious Diseases, Erasmus University Medical Centre, Rotterdam, The Netherlands"},{"name":"Department of Medical Microbiology, Haaglanden Medical Centre, The Hague, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,11]]},"reference":[{"key":"2019051708103354200_dkz095-B1","first-page":"183","article-title":"Reappraisal of the risk\/benefit of nitrofurantoin: review of toxicity and efficacy","volume":"8","author":"Shah","year":"1989","journal-title":"Adverse Drug React Acute Poisoning Rev"},{"key":"2019051708103354200_dkz095-B2"},{"key":"2019051708103354200_dkz095-B3","doi-asserted-by":"crossref","first-page":"e103","DOI":"10.1093\/cid\/ciq257","article-title":"International clinical practice guidelines for the treatment of acute uncomplicated cystitis and pyelonephritis in women: a 2010 update by the Infectious Diseases Society of America and the European Society for Microbiology and Infectious Diseases","volume":"52","author":"Gupta","year":"2011","journal-title":"Clin Infect Dis"},{"key":"2019051708103354200_dkz095-B4","doi-asserted-by":"crossref","first-page":"972.","DOI":"10.1016\/j.cmi.2017.12.026","article-title":"Effect of outpatient antibiotics for urinary tract infections on antimicrobial resistance among commensal Enterobacteriaceae: a multinational prospective cohort study","volume":"24","author":"Stewardson","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"2019051708103354200_dkz095-B5","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/j.cmi.2014.11.016","article-title":"Collateral damage from oral ciprofloxacin versus nitrofurantoin in outpatients with urinary tract infections: a culture-free analysis of gut microbiota","volume":"21","author":"Stewardson","year":"2015","journal-title":"Clin Microbiol Infect"},{"key":"2019051708103354200_dkz095-B6","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/jac\/dkv147","article-title":"Nitrofurantoin revisited: a systematic review and meta-analysis of controlled trials","volume":"70","author":"Huttner","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"2019051708103354200_dkz095-B7","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1001\/jama.2018.3627","article-title":"Effect of 5-day nitrofurantoin vs single-dose fosfomycin on clinical resolution of uncomplicated lower urinary tract infection in women: a randomized clinical trial","volume":"319","author":"Huttner","year":"2018","journal-title":"JAMA"},{"key":"2019051708103354200_dkz095-B8","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1093\/jac\/dky255","article-title":"Review of the pharmacokinetic properties of nitrofurantoin and nitroxoline","volume":"73","author":"Wijma","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"2019051708103354200_dkz095-B9","first-page":"718","article-title":"[Summary of the practice guideline \u2018Urinary-tract infections\u2019 (second revision) from the Dutch College of General Practitioners]","volume":"150","author":"van Pinxteren","year":"2006","journal-title":"Ned Tijdschr Geneeskd"},{"key":"2019051708103354200_dkz095-B10","first-page":"S203","article-title":"[AFSSAPS Practice recommendations for diagnosis and antibiotic therapy of adult community urinary tract infections]","volume":"38","year":"2008","journal-title":"Med Mal Infect"},{"key":"2019051708103354200_dkz095-B11"},{"key":"2019051708103354200_dkz095-B12","year":"2012"},{"key":"2019051708103354200_dkz095-B13","year":"2018"},{"key":"2019051708103354200_dkz095-B14","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1056\/NEJM196805092781902","article-title":"Effect of renal function on urinary recovery of orally administered nitrofurantoin","volume":"278","author":"Sachs","year":"1968","journal-title":"N Engl J Med"},{"key":"2019051708103354200_dkz095-B15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/00007611-195502000-00008","article-title":"Furadantin: human blood level and urinary concentration","volume":"48","author":"Carroll","year":"1955","journal-title":"South Med J"},{"key":"2019051708103354200_dkz095-B16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0002-9343(71)90268-3","article-title":"Neural, hematologic and bacteriologic effects of nitrofurantoin in renal insufficiency","volume":"51","author":"Felts","year":"1971","journal-title":"Am J Med"},{"key":"2019051708103354200_dkz095-B17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1365-2125.2008.03184.x","article-title":"The ABCG2 C421A polymorphism does not affect oral nitrofurantoin pharmacokinetics in healthy Chinese male subjects","volume":"66","author":"Adkison","year":"2008","journal-title":"Br J Clin Pharmacol"},{"key":"2019051708103354200_dkz095-B18","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0378-5173(84)90205-9","article-title":"A flip-flop model for nitrofurantoin disposition in the rabbit following oral administration","volume":"21","author":"Watari","year":"1984","journal-title":"Int J Pharm"},{"key":"2019051708103354200_dkz095-B19","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1093\/jac\/dkw212","article-title":"Pharmacodynamics and differential activity of nitrofurantoin against ESBL-positive pathogens involved in urinary tract infections","volume":"71","author":"Fransen","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"2019051708103354200_dkz095-B20","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0022-5347(17)67025-3","article-title":"Nitrofurantoin, sulfamethizole and cephalexin urinary concentration in unequally functioning pyelonephritic kidneys","volume":"114","author":"Sullivan","year":"1975","journal-title":"J Urol"},{"key":"2019051708103354200_dkz095-B21","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-5347(17)66138-X","article-title":"A theory concerning recurrence of urinary infection: prolonged administration of nitrofurantoin for prevention","volume":"80","author":"Lippman","year":"1958","journal-title":"J Urol"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/74\/6\/1656\/28666566\/dkz095.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,17]],"date-time":"2019-05-17T08:11:30Z","timestamp":1558080690000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/74\/6\/1656\/5374845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,11]]},"references-count":21,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,3,11]]},"published-print":{"date-parts":[[2019,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkz095","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,6]]},"published":{"date-parts":[[2019,3,11]]}}}