{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T21:06:58Z","timestamp":1793740018532,"version":"4.6.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T00:00:00Z","timestamp":1556841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Taiwan Ministry of Science and Technology Grants","award":["MOST 104-2314-B-002-039-MY3"],"award-info":[{"award-number":["MOST 104-2314-B-002-039-MY3"]}],"id":[{"id":"https:\/\/ror.org\/02kv4zf79","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Taiwan Ministry of Science and Technology Grants","award":["MOST 106-2811-B-002-048"],"award-info":[{"award-number":["MOST 106-2811-B-002-048"]}],"id":[{"id":"https:\/\/ror.org\/02kv4zf79","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Taiwan Ministry of Science and Technology Grants","award":["MOST 107-2314-B-002-196"],"award-info":[{"award-number":["MOST 107-2314-B-002-196"]}],"id":[{"id":"https:\/\/ror.org\/02kv4zf79","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005762","name":"National Taiwan University Hospital","doi-asserted-by":"publisher","award":["NTUH.106-P04"],"award-info":[{"award-number":["NTUH.106-P04"]}],"id":[{"id":"10.13039\/501100005762","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Prosthetic joint infections (PJIs) often require long-course antibiotic therapy. However, recent studies argue against the current practice and raise concerns such as the development of antibiotic resistance, side effects of medications and medical costs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To review and compare the outcomes of short-course and long-course antibiotics in PJIs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a systemic review and meta-analysis using a predefined search term in PubMed and EMBASE databases. Studies that met the inclusion criteria from inception to June 2018 were included. The quality of the included studies was assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 10 articles and 856 patients were analysed, comprising 9 observational studies and 1 randomized controlled trial. Our meta-analysis showed no significant difference between short-course and long-course antibiotics (relative risk\u205f=\u205f0.87, 95% CI\u205f=\u205f0.62\u20131.22). Additionally, the older the studied group was, the more short-course antibiotics were favoured.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>When treating PJI patients following debridement, antibiotics and implant retention, an 8\u2009week course of antibiotic therapy for total hip arthroplasty and a 75\u2009day course for total knee arthroplasty may be a safe approach. For two-stage exchange, a shorter duration of antibiotic treatment during implant-free periods is also generally safe with the usage of antibiotic-loaded cement spacers.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkz166","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T23:13:35Z","timestamp":1554851615000},"page":"2507-2516","source":"Crossref","is-referenced-by-count":21,"title":["Short-course versus long-course antibiotics in prosthetic joint infections: a systematic review and meta-analysis of one randomized controlled trial plus nine observational studies"],"prefix":"10.1093","volume":"74","author":[{"given":"Hung-Teng","family":"Yen","sequence":"first","affiliation":[{"name":"School of Medicine, National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronan W","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Albert Einstein Medical Center, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-yen","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Medicine, National Taiwan University College of Medicine, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzu-Chun","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Yeh","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, University of California, Davis, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yee-Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Shan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Taichung Veterans General Hospital, Taichung, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chang","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, National Taiwan University Hospital, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,3]]},"reference":[{"key":"2019091012163021900_dkz166-B1","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.arth.2007.10.017","article-title":"Infection burden for hip and knee arthroplasty in the United States","volume":"23","author":"Kurtz","year":"2008","journal-title":"J 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