{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:43:09Z","timestamp":1785552189743,"version":"3.56.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T00:00:00Z","timestamp":1557705600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Science, Technology and Productive Innovation Ministry","award":["PICT2016\/1985"],"award-info":[{"award-number":["PICT2016\/1985"]}]},{"DOI":"10.13039\/501100000313","name":"British Society for Antimicrobial Chemotherapy","doi-asserted-by":"publisher","award":["BSAC-2017-0022"],"award-info":[{"award-number":["BSAC-2017-0022"]}],"id":[{"id":"10.13039\/501100000313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"CONICET","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Candida auris is an emerging MDR pathogen. It shows reduced susceptibility to azole drugs and, in some strains, high amphotericin B MICs have been described. For these reasons, echinocandins were proposed as first-line treatment for C. auris infections. However, information on how echinocandins and amphotericin B act against this species is lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Our aim was to establish the killing kinetics of anidulafungin, caspofungin and amphotericin B against C. auris by time\u2013kill methodology and to determine if these antifungals behave as fungicidal or fungistatic agents against this species.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The susceptibility of 50\u2009C. auris strains was studied. Nine strains were selected (based on echinocandin MICs) to be further studied. Minimal fungicidal concentrations, in vitro dose\u2013response and time\u2013kill patterns were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Echinocandins showed lower MIC values than amphotericin B (geometric mean of 0.12 and 0.94\u2009mg\/L, respectively). Anidulafungin and caspofungin showed no fungicidal activity at any concentration (maximum log decreases in cfu\/mL between 1.34 and 2.22). On the other hand, amphotericin B showed fungicidal activity, but at high concentrations (\u22652.00\u2009mg\/L). In addition, the tested polyene was faster than echinocandins at killing 50% of the initial inoculum (0.92 versus &gt;8.00\u2009h, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Amphotericin B was the only agent regarded as fungicidal against C. auris. Moreover, C. auris should be considered tolerant to caspofungin and anidulafungin considering that their MFC:MIC ratios were mostly \u226532 and that after 6\u2009h of incubation the starting inoculum was not reduced in &gt;90%.<\/jats:p><\/jats:sec>","DOI":"10.1093\/jac\/dkz178","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T22:50:34Z","timestamp":1557269434000},"page":"2295-2302","source":"Crossref","is-referenced-by-count":45,"title":["Antifungal activity and killing kinetics of anidulafungin, caspofungin and amphotericin B against Candida auris"],"prefix":"10.1093","volume":"74","author":[{"given":"Catiana","family":"Dudiuk","sequence":"first","affiliation":[{"name":"Laboratorio de Micolog\u00eda y Diagn\u00f3stico Molecular, C\u00e1tedra de Parasitolog\u00eda y Micolog\u00eda, Facultad de Bioqu\u00edmica y Ciencias Biol\u00f3gicas, Universidad Nacional del Litoral, Santa Fe, Argentina"},{"name":"Consejo Nacional de Investigaciones 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Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Morales-Lopez","sequence":"additional","affiliation":[{"name":"Universidad de Santander, Facultad de Ciencias de la Salud, Grupo de Investigaci\u00f3n CIENCIA UDES, Valledupar, Colombia"},{"name":"Laboratorios Nancy Fl\u00f3rez Garc\u00eda S.A.S., Valledupar, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Theill","sequence":"additional","affiliation":[{"name":"Laboratorio de Micolog\u00eda y Diagn\u00f3stico Molecular, C\u00e1tedra de Parasitolog\u00eda y Micolog\u00eda, Facultad de Bioqu\u00edmica y Ciencias Biol\u00f3gicas, Universidad Nacional del Litoral, Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiana","family":"Macedo","sequence":"additional","affiliation":[{"name":"Laboratorio de Micolog\u00eda y Diagn\u00f3stico Molecular, C\u00e1tedra de Parasitolog\u00eda y Micolog\u00eda, Facultad de Bioqu\u00edmica y Ciencias Biol\u00f3gicas, Universidad Nacional del Litoral, Santa Fe, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET), CCT, Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Yesid-Rodriguez","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Microbiol\u00f3gicas del Cesar, CIMCE, Valledupar, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"Salcedo","sequence":"additional","affiliation":[{"name":"Cl\u00ednica General del Norte, Barranquilla, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Marin","sequence":"additional","affiliation":[{"name":"Cl\u00ednica General del Norte, Barranquilla, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soledad","family":"Gamarra","sequence":"additional","affiliation":[{"name":"Laboratorio de Micolog\u00eda y Diagn\u00f3stico Molecular, C\u00e1tedra de Parasitolog\u00eda y Micolog\u00eda, Facultad de Bioqu\u00edmica y Ciencias Biol\u00f3gicas, Universidad Nacional del Litoral, Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Garcia-Effron","sequence":"additional","affiliation":[{"name":"Laboratorio de Micolog\u00eda y Diagn\u00f3stico Molecular, C\u00e1tedra de Parasitolog\u00eda y Micolog\u00eda, Facultad de Bioqu\u00edmica y Ciencias Biol\u00f3gicas, Universidad Nacional del Litoral, Santa Fe, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y Tecnol\u00f3gicas (CONICET), CCT, Santa Fe, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,12]]},"reference":[{"key":"2019071909302540800_dkz178-B1","doi-asserted-by":"crossref","DOI":"10.3201\/eid2302.161486","article-title":"Multidrug-resistant Candida haemulonii and C. 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