{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:57:32Z","timestamp":1791334652456,"version":"4.3.1"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T00:00:00Z","timestamp":1557273600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"University of the Basque Country UPV\/EHU","award":["GIU17\/32"],"award-info":[{"award-number":["GIU17\/32"]}]},{"name":"University of the Basque Country UPV\/EHU","award":["PPG17\/65"],"award-info":[{"award-number":["PPG17\/65"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"Abstract<\/jats:title>\n \n Objectives<\/jats:title>\n The aim of this study was to compare antimicrobial susceptibility rates in a Spanish ICU before and after the introduction of selective digestive decontamination (SDD) and also to compare these with susceptibility data from other Spanish ICUs without SDD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n We performed a retrospective study in the ICU of the University Hospital of Alava, where SDD was implemented in 2002. The SDD protocol consisted of a 2% mixture of gentamicin, colistin and amphotericin B applied on the buccal mucosa and a suspension of the same drugs in the gastrointestinal tract; additionally, for the first 3\u2009days, systemic ceftriaxone was administered. From 1998 to 2013 we analysed the susceptibility rates for 48 antimicrobial\/organism combinations. Interrupted time series using a linear dynamic model with SDD as an intervention was used. Data from other ICUs were obtained from the ENVIN-HELICS national registry.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Only amoxicillin\/clavulanic acid against Escherichia coli and Proteus mirabilis, and a high concentration of gentamicin against Enterococcus faecalis, resulted in a significant decrease in the susceptibility rate after the implementation of SDD, with a drop of 20%, 27% and 32%, respectively. Compared with other Spanish ICUs without SDD, the susceptibility rate was higher in the ICU of our hospital in most cases. When it was lower, differences were <10%, except for a high concentration of streptomycin against Enterococcus faecium, for which the difference was 19%.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n No relevant changes in the overall susceptibility rate after the implementation of SDD were detected. Susceptibility rates were not lower than those in the Spanish ICUs without SDD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/jac\/dkz186","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T19:31:50Z","timestamp":1555529510000},"page":"2289-2294","source":"Crossref","is-referenced-by-count":9,"title":["Antibiotic susceptibility trend before and after long-term use of selective digestive decontamination: a 16 year ecological study"],"prefix":"10.1093","volume":"74","author":[{"given":"Yanire","family":"Llor\u00e9ns-Villar","sequence":"first","affiliation":[{"name":"Servicio de Farmacia Hospitalaria, Hospital Universitario de \u00c1lava, Vitoria-Gasteiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Tusell","sequence":"additional","affiliation":[{"name":"Departamento de Econom\u00eda Aplicada III, Facultad de Ciencias Econ\u00f3micas y Empresariales, Universidad del Pa\u00eds Vasco UPV\/EHU, Bilbao, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9s","family":"Canut","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario de \u00c1lava, Vitoria-Gasteiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Barrasa","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Intensiva, Hospital Universitario de \u00c1lava, Vitoria-Gasteiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Corral","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Intensiva, Hospital Universitario de \u00c1lava, Vitoria-Gasteiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Intensiva, Hospital Universitario de \u00c1lava, Vitoria-Gasteiz, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia","family":"Rodr\u00edguez-Gasc\u00f3n","sequence":"additional","affiliation":[{"name":"Farmacia y Tecnolog\u00eda Farmac\u00e9utica, Facultad de Farmacia, Centro de investigaci\u00f3n Lascaray ikergunea, Universidad del Pa\u00eds Vasco UPV\/EHU, Vitoria, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,7]]},"reference":[{"key":"2019071909301459000_dkz186-B1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.cmi.2017.08.019","article-title":"Selective digestive and oropharyngeal decontamination in medical and surgical ICU patients: individual patient data meta-analysis","volume":"24","author":"Plantinga","year":"2018","journal-title":"Clin Microbiol Infect"},{"key":"2019071909301459000_dkz186-B2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.aucc.2013.04.002","article-title":"Clinical components and 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