{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:56:11Z","timestamp":1769244971159,"version":"3.49.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,7,12]],"date-time":"2019-07-12T00:00:00Z","timestamp":1562889600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Institut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer"},{"name":"IDIBAPS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The best therapeutic approach for treating MRSA endocarditis remains unknown, particularly in cases of high vancomycin MICs. We report here a case of daptomycin-non-susceptible, ceftaroline-resistant and fosfomycin-resistant MRSA native left valve endocarditis that was successfully treated with valve repair and a combination of high-dose daptomycin and ceftaroline.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Antimicrobial testing of the clinical strain was performed using Etest and microdilution broth methods. Time\u2013kill and chequerboard methodologies were used to test the activity of antibiotic combinations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>By Etest, the MIC of vancomycin was 2\u2009mg\/L, the MIC of daptomycin was 2\u2009mg\/L, the MIC of fosfomycin was 1024\u2009mg\/L and the MIC of ceftaroline was 1.5\u2009mg\/L. At the standard inoculum (105\u2009cfu\/mL), the three combinations of daptomycin plus ceftaroline, cloxacillin or fosfomycin were synergistic and bactericidal. However, when these combinations were tested using a higher inoculum (108\u2009cfu\/mL), all combinations were synergistic, but only daptomycin plus ceftaroline had bactericidal activity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These results confirmed a synergistic effect between daptomycin plus ceftaroline and increased bactericidal activity against MRSA, suggesting that this combination may be effective for the treatment of invasive MRSA infection. Our experience highlights the potential clinical use of synergy testing to guide difficult treatment decisions in patients with MDR MRSA infection.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkz253","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T11:09:40Z","timestamp":1558955380000},"page":"2626-2630","source":"Crossref","is-referenced-by-count":13,"title":["Successful treatment with daptomycin and ceftaroline of MDR Staphylococcus aureus native valve endocarditis: a case report"],"prefix":"10.1093","volume":"74","author":[{"given":"Fran\u00e7ois-R\u00e9gis","family":"Duss","sequence":"first","affiliation":[{"name":"Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Garcia de la M\u00e0ria","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Hospital Clinic-IDIBAPS, University of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antony","family":"Croxatto","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Giulieri","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Lamoth","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, University Hospital and University of Lausanne, Lausanne, Switzerland"},{"name":"Institute of Microbiology, University Hospital and University of Lausanne, Lausanne, 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