{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T01:05:08Z","timestamp":1786237508522,"version":"build-2736575974"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Merck & Co."},{"name":"Inc."}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>First-line antifungal treatment for invasive mucormycosis (IM) consists of liposomal amphotericin B. Salvage treatment options are limited and often based on posaconazole oral suspension. With the approval of posaconazole new formulations, patients could benefit from improved pharmacokinetics, safety and tolerability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Our aim was to assess the effectiveness of posaconazole new formulations for IM treatment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a case-matched analysis with proven or probable IM patients from the FungiScope\u00ae Registry. First-line posaconazole new formulations (1st-POSnew) and first-line amphotericin B plus posaconazole new formulations (1st-AMB+POSnew) cases were matched with first-line amphotericin B-based (1st-AMB) treatment controls. Salvage posaconazole new formulations (SAL-POSnew) cases were matched with salvage posaconazole oral suspension (SAL-POSsusp) controls. Each case was matched with up to three controls (based on severity, haematological\/oncological malignancy, surgery and\/or renal dysfunction).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Five patients receiving 1st-POSnew, 18 receiving 1st-AMB+POSnew and 22 receiving SAL-POSnew were identified. By day 42, a favourable response was reported for 80.0% (n\u205f=\u205f4\/5) of patients receiving 1st-POSnew, for 27.8% (n\u205f=\u205f5\/18) receiving 1st-AMB+POSnew and for 50.0% (n\u205f=\u205f11\/22) receiving SAL-POSnew. Day 42 all-cause mortality of patients receiving posaconazole new formulations was lower compared with controls [20.0% (n\u205f=\u205f1\/5) in 1st-POSnew versus 53.3% (n\u205f=\u205f8\/15) in 1st-AMB; 33.3% (n\u205f=\u205f6\/18) in 1st-AMB+POSnew versus 52.0% (n\u205f=\u205f26\/50) in 1st-AMB; and 0.0% (n\u205f=\u205f0\/22) in SAL-POSnew versus 4.4% (n\u205f=\u205f2\/45) in SAL-POSsusp].<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Posaconazole new formulations were effective in terms of treatment response and associated mortality of IM. While posaconazole new formulations may be an alternative for treatment of IM, the limited sample size of our study calls for a cautious interpretation of these observations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jac\/dkz344","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T11:07:59Z","timestamp":1563275279000},"page":"3315-3327","source":"Crossref","is-referenced-by-count":43,"title":["Matched-paired analysis of patients treated for invasive mucormycosis: standard treatment versus posaconazole new formulations (MoveOn)"],"prefix":"10.1093","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6766-8297","authenticated-orcid":false,"given":"Jon","family":"Salmanton-Garc\u00eda","sequence":"first","affiliation":[{"name":"University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), European Diamond Excellence Center for Medical Mycology (ECMM), Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danila","family":"Seidel","sequence":"additional","affiliation":[{"name":"University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), European Diamond Excellence Center for Medical Mycology (ECMM), Cologne, Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Koehler","sequence":"additional","affiliation":[{"name":"University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), European Diamond Excellence Center for Medical Mycology (ECMM), Cologne, Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibylle C","family":"Mellinghoff","sequence":"additional","affiliation":[{"name":"University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), European Diamond Excellence Center for Medical Mycology (ECMM), Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raoul","family":"Herbrecht","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology, H\u00f4pitaux Universitaires de Strasbourg and Universit\u00e9 de Strasbourg, Inserm, UMR-S1113\/IRFAC, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai","family":"Klimko","sequence":"additional","affiliation":[{"name":"Department of Clinical Mycology, Allergy and Immunology, North Western State Medical University, Saint Petersburg, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zden\u011bk","family":"R\u00e1\u010dil","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine-Hematology and Oncology, Masaryk University, Brno, Czech Republic"},{"name":"University Hospital Brno, Brno, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5888-7706","authenticated-orcid":false,"given":"Iker","family":"Falces-Romero","sequence":"additional","affiliation":[{"name":"Clinical Microbiology and Parasitology Department, University Hospital La Paz, Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Ingram","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Royal Perth Hospital, Perth, WA, Australia"},{"name":"School of Pathology and Laboratory Medicine, University of Western Australia, Perth, WA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel-\u00c1ngel","family":"Ben\u00edtez-Pe\u00f1uela","sequence":"additional","affiliation":[{"name":"Center of Microbiological Research of Cesar (CIMCE), Rosario Pumarejo de L\u00f3pez Hospital, Laura Daniela Clinic, M\u00e9dicos Clinic LTDA, Valledupar, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Yesid","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Center of Microbiological Research of Cesar (CIMCE), Rosario Pumarejo de L\u00f3pez Hospital, Laura Daniela Clinic, M\u00e9dicos Clinic LTDA, Valledupar, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Desoubeaux","sequence":"additional","affiliation":[{"name":"Parasitology, Mycology and Tropical Medicine Service, University Hospital of Tours, Tours, France"},{"name":"Inserm U1100, Tours University, Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Bara\u0107","sequence":"additional","affiliation":[{"name":"Clinic for Infectious and Tropical Diseases, Clinical Centre of Serbia, Faculty of Medicine, University of Belgrade, Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Garc\u00eda-Vidal","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases, Cl\u00ednic Hospital, University of Barcelona, Institute of Biomedical Research August Pi i Sunyer, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hoenigl","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of California San Diego, San Diego, CA, USA"},{"name":"Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay R","family":"Mehta","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, University of California San Diego, San Diego, CA, USA"},{"name":"Department of Medicine, San Diego Veterans Affairs Medical Center San Diego, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4867-2063","authenticated-orcid":false,"given":"Matthew P","family":"Cheng","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Departments of Medicine, Microbiology and Immunology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina","family":"Klyasova","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Mycology and Antibiotic Therapy, National Research Center for Hematology, Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner J","family":"Heinz","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II, Julius Maximilians University, W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nousheen","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Section of Pulmonology and Critical Care, Department of Medicine, Aga Khan University Hospital, Karachi, Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Krause","sequence":"additional","affiliation":[{"name":"Section of Infectious Diseases and Tropical Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Ostermann","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Penack","sequence":"additional","affiliation":[{"name":"Department for Hematology, Oncology and Tumorimmunology, Charit\u00e9 University Medicine Berlin, Campus Virchow Clinic, Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Schalk","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology, Medical Centre, Otto-von-Guericke University Magdeburg, Magdeburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald C","family":"Sheppard","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Departments of Medicine, Microbiology and Immunology, Research Institute of the McGill University Health Centre, Montreal, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Willinger","sequence":"additional","affiliation":[{"name":"Division of Clinical Microbiology, Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilmar","family":"Wisplinghoff","sequence":"additional","affiliation":[{"name":"University of Cologne, Institute for Medical Microbiology, Immunology and Hygiene, Cologne, Germany"},{"name":"Wisplinghoff Laboratories, Cologne, Germany"},{"name":"Institute for Virology and Clinical Microbiology, Witten\/Herdecke University, Witten, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Janne","family":"Vehreschild","sequence":"additional","affiliation":[{"name":"University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), European Diamond Excellence Center for Medical Mycology (ECMM), Cologne, Germany"},{"name":"German Centre for Infection Research (DZIF), partner site Bonn - Cologne, Cologne, Germany"},{"name":"Center for Integrated Oncology CIO K\u00f6ln\/Bonn, Medical Faculty, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9599-3137","authenticated-orcid":false,"given":"Oliver A","family":"Cornely","sequence":"additional","affiliation":[{"name":"University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), European Diamond Excellence Center for Medical Mycology (ECMM), Cologne, Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany"},{"name":"German Centre for Infection Research (DZIF), partner site Bonn - Cologne, Cologne, Germany"},{"name":"Center for Integrated Oncology CIO K\u00f6ln\/Bonn, Medical Faculty, University of Cologne, Cologne, Germany"},{"name":"Clinical Trials Centre Cologne (ZKS K\u00f6ln), University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J G T","family":"Vehreschild","sequence":"additional","affiliation":[{"name":"University of Cologne, Faculty of Medicine and University Hospital of Cologne, Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf (CIO ABCD), European Diamond Excellence Center for Medical Mycology (ECMM), Cologne, Germany"},{"name":"German Centre for Infection Research (DZIF), partner site Bonn - Cologne, Cologne, Germany"},{"name":"Center for Integrated Oncology CIO K\u00f6ln\/Bonn, Medical Faculty, University of Cologne, Cologne, Germany"},{"name":"Department of Internal Medicine, Infectious Diseases, Goethe University, Frankfurt, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The FungiScope\u00ae ECMM\/ISHAM Working Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reham Abdelaziz","family":"Khedr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Arencibia-N\u00fa\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Avil\u00e9s-Robles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Banke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariful","family":"Basher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keertilaxmi","family":"Benachinamardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harmut","family":"Bertz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunaloke","family":"Chakrabarti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lubos","family":"Drgona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Garc\u00eda-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Garc\u00eda-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Gr\u00e4ber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"H\u00e4rter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Kouba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-Gun","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohann","family":"Le Govic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Leo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Maertens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Maschmeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Meintker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Dong","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena-Katharina","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy Stephen","family":"Nel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Nov\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frieder","family":"Pf\u00e4fflin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan-Carlos","family":"Pozo-Laderas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Puerta-Alcalde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azucena","family":"Rodr\u00edguez-Guardado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Schroers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vandana","family":"Shekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Shenoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerda","family":"Silling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Vinh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salom\u00f3n","family":"Waizel-Haiat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy Yap","family":"Yee Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peralam Yegneswaran","family":"Prakash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"\u017d\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,8,8]]},"reference":[{"key":"2019101809592554200_dkz344-B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0179136","article-title":"Increasing incidence of mucormycosis in a large Spanish hospital from 2007 to 2015: epidemiology and microbiological characterization of the isolates","volume":"12","author":"Guinea","year":"2017","journal-title":"PLoS One"},{"key":"2019101809592554200_dkz344-B2","doi-asserted-by":"crossref","first-page":"667.","DOI":"10.1186\/s12879-016-2005-1","article-title":"Invasive mucormycosis in children: an epidemiologic study in European and non-European countries based on two registries","volume":"16","author":"Pana","year":"2016","journal-title":"BMC Infect Dis"},{"key":"2019101809592554200_dkz344-B3","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1086\/651263","article-title":"Prospective surveillance for invasive fungal infections in hematopoietic stem cell transplant recipients, 2001\u20132006: overview of the Transplant-Associated Infection Surveillance Network (TRANSNET) Database","volume":"50","author":"Kontoyiannis","year":"2010","journal-title":"Clin Infect Dis"},{"key":"2019101809592554200_dkz344-B4","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.3201\/eid1710.110087","article-title":"Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001\u20132006","volume":"17","author":"Park","year":"2011","journal-title":"Emerg Infect Dis"},{"key":"2019101809592554200_dkz344-B5","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/1469-0691.12371","article-title":"ESCMID and ECMM joint clinical guidelines for the diagnosis and management of mucormycosis 2013","volume":"20 Suppl 3","author":"Cornely","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"2019101809592554200_dkz344-B6","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1086\/432579","article-title":"Epidemiology and outcome of zygomycosis: a review of 929 reported cases","volume":"41","author":"Roden","year":"2005","journal-title":"Clin Infect Dis"},{"key":"2019101809592554200_dkz344-B7","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1086\/590004","article-title":"Delaying amphotericin B-based frontline therapy significantly increases mortality among patients with hematologic malignancy who have zygomycosis","volume":"47","author":"Chamilos","year":"2008","journal-title":"Clin Infect Dis"},{"key":"2019101809592554200_dkz344-B8","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1086\/599105","article-title":"Recent advances in the management of mucormycosis: from bench to bedside","volume":"48","author":"Spellberg","year":"2009","journal-title":"Clin Infect Dis"},{"key":"2019101809592554200_dkz344-B9","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1056\/NEJMoa040446","article-title":"Caspofungin versus liposomal amphotericin B for empirical antifungal therapy in patients with persistent fever and neutropenia","volume":"351","author":"Walsh","year":"2004","journal-title":"N Engl J Med"},{"key":"2019101809592554200_dkz344-B10","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1111\/myc.12524","article-title":"Utilization of posaconazole oral suspension or delayed-released tablet salvage treatment for invasive fungal infection","volume":"59","author":"Kim","year":"2016","journal-title":"Mycoses"},{"key":"2019101809592554200_dkz344-B11","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1093\/jac\/dkv236","article-title":"Prospective pilot study of high-dose (10 mg\/kg\/day) liposomal amphotericin B (L-AMB) for the initial treatment of mucormycosis","volume":"70","author":"Lanternier","year":"2015","journal-title":"J Antimicrob Chemother"},{"key":"2019101809592554200_dkz344-B12","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/MD.0b013e3181e9441b","article-title":"Drug-induced nephrotoxicity caused by amphotericin B lipid complex and liposomal amphotericin B: a review and meta-analysis","volume":"89","author":"Safdar","year":"2010","journal-title":"Medicine (Baltimore)"},{"key":"2019101809592554200_dkz344-B13","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1128\/AAC.00452-07","article-title":"In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents","volume":"51","author":"Almyroudis","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"2019101809592554200_dkz344-B14","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1128\/AAC.00163-06","article-title":"In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts","volume":"50","author":"Sabatelli","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"2019101809592554200_dkz344-B15","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3109\/1040841X.2012.711741","article-title":"Mucormycosis treated with posaconazole: review of 96 case reports","volume":"39","author":"Vehreschild","year":"2013","journal-title":"Crit Rev Microbiol"},{"key":"2019101809592554200_dkz344-B16","doi-asserted-by":"crossref","first-page":"e61","DOI":"10.1086\/500212","article-title":"Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 cases","volume":"42","author":"van Burik","year":"2006","journal-title":"Clin Infect Dis"},{"key":"2019101809592554200_dkz344-B17","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1111\/myc.12911","article-title":"Posaconazole salvage therapy: the Posifi study","volume":"62","author":"Fort\u00fan","year":"2019","journal-title":"Mycoses"},{"key":"2019101809592554200_dkz344-B18","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2015-213700","article-title":"Primary cutaneous mucormycosis developing after incision and drainage of a subcutaneous abscess in an immunocompetent host","author":"Beatty","year":"2016","journal-title":"BMJ Case Rep"},{"key":"2019101809592554200_dkz344-B19","doi-asserted-by":"crossref","first-page":"4424","DOI":"10.1128\/AAC.00581-15","article-title":"Superior serum concentrations with posaconazole delayed-release tablets compared to suspension formulation in hematological malignancies","volume":"59","author":"Cumpston","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"2019101809592554200_dkz344-B20","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.1128\/AAC.00222-12","article-title":"Single-dose phase I study to evaluate the pharmacokinetics of posaconazole in new tablet and capsule formulations relative to oral suspension","volume":"56","author":"Krishna","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"2019101809592554200_dkz344-B21","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/jac\/dks268","article-title":"A new solid oral tablet formulation of posaconazole: a randomized clinical trial to investigate rising single- and multiple-dose pharmacokinetics and safety in healthy volunteers","volume":"67","author":"Krishna","year":"2012","journal-title":"J Antimicrob Chemother"},{"key":"2019101809592554200_dkz344-B22","doi-asserted-by":"crossref","first-page":"3610","DOI":"10.1128\/AAC.02686-13","article-title":"Phase 1B study of the pharmacokinetics and safety of posaconazole intravenous solution in patients at risk for invasive fungal disease","volume":"58","author":"Maertens","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"2019101809592554200_dkz344-B23","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1093\/jac\/dkv380","article-title":"Phase 3 pharmacokinetics and safety study of a posaconazole tablet formulation in patients at risk for invasive fungal disease","volume":"71","author":"Cornely","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"2019101809592554200_dkz344-B24","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1007\/s00432-017-2369-7","article-title":"Efficacy, safety and feasibility of antifungal prophylaxis with posaconazole tablet in paediatric patients after haematopoietic stem cell transplantation","volume":"143","author":"Doring","year":"2017","journal-title":"J Cancer Res Clin Oncol"},{"key":"2019101809592554200_dkz344-B25","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1111\/myc.12631","article-title":"FungiScope\u2122-Global Emerging Fungal Infection Registry","volume":"60","author":"Seidel","year":"2017","journal-title":"Mycoses"},{"key":"2019101809592554200_dkz344-B26","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/jac\/dkp430","article-title":"Forty-one recent cases of invasive zygomycosis from a global clinical registry","volume":"65","author":"R\u00fcping","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"2019101809592554200_dkz344-B27","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1086\/588660","article-title":"Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer\/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC\/MSG) Consensus Group","volume":"46","author":"De Pauw","year":"2008","journal-title":"Clin Infect Dis"},{"key":"2019101809592554200_dkz344-B28","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1179\/joc.2009.21.3.272","article-title":"In vitro antifungal activity of isavuconazole against 345 Mucorales isolates collected at study centers in eight countries","volume":"21","author":"Verweij","year":"2009","journal-title":"J Chemother"},{"key":"2019101809592554200_dkz344-B29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1469-0691.2009.02984.x","article-title":"In vitro activity of antifungals against Zygomycetes","volume":"15 Suppl 5","author":"Alastruey-Izquierdo","year":"2009","journal-title":"Clin Microbiol Infect"},{"key":"2019101809592554200_dkz344-B30","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1086\/590566","article-title":"Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria","volume":"47","author":"Segal","year":"2008","journal-title":"Clin Infect Dis"},{"key":"2019101809592554200_dkz344-B31","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S1473-3099(16)00071-2","article-title":"Isavuconazole treatment for mucormycosis: a single-arm open-label trial and case\u2013control analysis","volume":"16","author":"Marty","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"2019101809592554200_dkz344-B32","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/phar.1533","article-title":"Review of the new delayed-release oral tablet and intravenous dosage forms of posaconazole","volume":"35","author":"Guarascio","year":"2015","journal-title":"Pharmacotherapy"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/74\/11\/3315\/30192865\/dkz344.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/74\/11\/3315\/30192865\/dkz344.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,21]],"date-time":"2020-05-21T17:04:00Z","timestamp":1590080640000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/74\/11\/3315\/5545108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,8]]},"references-count":32,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,8,8]]},"published-print":{"date-parts":[[2019,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkz344","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,11]]},"published":{"date-parts":[[2019,8,8]]}}}