{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:03:48Z","timestamp":1789139028625,"version":"build-2803163510"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Montpellier University Hospital and Montpellier University"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute haematogenous bone and joint infections (AHBJI) represent a diagnostic and therapeutic emergency in children, with significant potential sequelae in the case of delayed treatment. Although historically the recommendations for treatment have been based on surgery and prolonged antibiotic therapy, recent studies have demonstrated that short-course antibiotic therapy is also effective.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We evaluated a short-term antibiotic protocol for both osteomyelitis and septic arthritis in a 6\u2009year retrospective study at the University Hospital of Montpellier.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This protocol was based on an initial intravenous treatment with a re-evaluation after 48\u2009h and an early switch to oral therapy in the case of a favourable clinical course for a minimum total duration of 15\u2009days. Antibiotics were selected based on local microbiological epidemiology and systematically adapted to bacteriological results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>One hundred and seventy-six cases of AHBJI were included, comprising 56 patients with osteomyelitis, 95 with septic arthritis and 25 who had both of these. The aetiological agent was identified in 42% of the cases, with the main pathogens being Staphylococcus aureus (39%) and Kingella kingae (27%). The mean intravenous treatment duration was 4\u2009days, while the total treatment duration was 15\u2009days. There were no treatment failures, mild sequelae occurred in 1% of the cases and the secondary surgical revision rate was 7%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The results of this study are comparable to those reported for evaluations of prolonged antibiotic therapy protocols, thus indicating that a common short-term antimicrobial therapy for the management of both osteomyelitis and septic arthritis (minimum of 15\u2009days) is a viable option for treating AHBJI in children. Further prospective studies to confirm these findings are hence warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jac\/dkz358","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T15:31:25Z","timestamp":1567006285000},"page":"3579-3587","source":"Crossref","is-referenced-by-count":30,"title":["Short-course antibiotic treatment of bone and joint infections in children: a retrospective study at Montpellier University Hospital from 2009 to 2013"],"prefix":"10.1093","volume":"74","author":[{"given":"A","family":"Filleron","sequence":"first","affiliation":[{"name":"Service de p\u00e9diatrie, CHU de N\u00eemes, N\u00eemes, France; INSERM U 1183, Universit\u00e9 Montpellier-N\u00eemes, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M E","family":"Laurens","sequence":"additional","affiliation":[{"name":"D\u00e9partement de p\u00e9diatrie n\u00e9onatale et de r\u00e9animation, CHU de Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Marin","sequence":"additional","affiliation":[{"name":"Department d\u2019Information Medicale, CHU Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H","family":"Marchandin","sequence":"additional","affiliation":[{"name":"HydroSciences Montpellier, University of Montpellier, CNRS, IRD, Montpellier, France; Laboratoire de microbiologie, CHU N\u00eemes, N\u00eemes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O","family":"Prodhomme","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019imagerie p\u00e9diatrique, CHU de Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Alkar","sequence":"additional","affiliation":[{"name":"Service de chirurgie orthop\u00e9dique infantile, CHU Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Godreuil","sequence":"additional","affiliation":[{"name":"Service de bact\u00e9riologie, CHU Montpellier, Montpellier, France"},{"name":"Universit\u00e9 de Montpellier UMR MIVEGEC, UMR IRD 224-CNRS Inserm, 1058, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Nagot","sequence":"additional","affiliation":[{"name":"Department d\u2019Information Medicale, CHU Montpellier, Montpellier, France"},{"name":"Pathogenesis and Control of Chronic Infections, INSERM, Universit\u00e9 de Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Cottalorda","sequence":"additional","affiliation":[{"name":"Service de chirurgie orthop\u00e9dique infantile, CHU Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"L\u2019Kaissi","sequence":"additional","affiliation":[{"name":"Service de chirurgie infantile, CHU de la r\u00e9union, Saint-Denis, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Rodiere","sequence":"additional","affiliation":[{"name":"D\u00e9partement urgences post-urgences, CHU Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M G","family":"Vigue","sequence":"additional","affiliation":[{"name":"D\u00e9partement urgences post-urgences, CHU Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M N","family":"Didelot","sequence":"additional","affiliation":[{"name":"Service de bact\u00e9riologie, CHU Montpellier, Montpellier, France"},{"name":"Pathogenesis and Control of Chronic Infections, INSERM, Universit\u00e9 de Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A L","family":"Michon","sequence":"additional","affiliation":[{"name":"Service de bact\u00e9riologie, CHU Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Delpont","sequence":"additional","affiliation":[{"name":"Service de chirurgie orthop\u00e9dique infantile, CHU Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Louahem","sequence":"additional","affiliation":[{"name":"Service de chirurgie orthop\u00e9dique infantile, CHU Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0318-3044","authenticated-orcid":false,"given":"E","family":"Jeziorski","sequence":"additional","affiliation":[{"name":"Pathogenesis and Control of Chronic Infections, INSERM, Universit\u00e9 de Montpellier, Montpellier, France"},{"name":"D\u00e9partement urgences post-urgences, CHU Montpellier, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"2019111507201639400_dkz358-B1","doi-asserted-by":"crossref","first-page":"45.","DOI":"10.1186\/1471-2431-8-45","article-title":"Childhood osteomyelitis\u2014incidence and differentiation from other acute onset musculoskeletal features in a population-based study","volume":"8","author":"Riise","year":"2008","journal-title":"BMC Pediatr"},{"key":"2019111507201639400_dkz358-B2","doi-asserted-by":"crossref","first-page":"e299","DOI":"10.1542\/peds.2007-0291","article-title":"Incidence and characteristics of arthritis in Norwegian children: a population-based study","volume":"121","author":"Riise","year":"2008","journal-title":"Pediatrics"},{"key":"2019111507201639400_dkz358-B3","first-page":"S81","article-title":"Epidemiology and physiopathology of osteoarticular infections in children (newborns except)","volume":"14 Suppl 2","author":"Grimpel","year":"2007","journal-title":"Arch Pediatr"},{"key":"2019111507201639400_dkz358-B4","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1136\/archdischild-2013-305860","article-title":"Hospital Network for Evaluating the Management of Infectious Diseases in Children. Community-acquired bone and joint infections in children: a 1-year prospective epidemiological study","volume":"100","author":"Mitha","year":"2015","journal-title":"Arch Dis Child"},{"key":"2019111507201639400_dkz358-B5","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/MOP.0b013e32835c2b42","article-title":"Osteomyelitis and septic arthritis in children: current concepts","volume":"25","author":"Dodwell","year":"2013","journal-title":"Curr Opin Pediatr"},{"key":"2019111507201639400_dkz358-B6","doi-asserted-by":"crossref","first-page":"S129","DOI":"10.1016\/j.otsr.2014.07.029","article-title":"Sequelae of pediatric osteoarticular infection","volume":"101 Suppl 1","author":"Ilharreborde","year":"2015","journal-title":"Orthop Traumatol Surg Res"},{"key":"2019111507201639400_dkz358-B7","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1097\/INF.0b013e3181f55a89","article-title":"Short- versus long-term antimicrobial treatment for acute hematogenous osteomyelitis of childhood: prospective, randomized trial on 131 culture-positive cases","volume":"29","author":"Peltola","year":"2010","journal-title":"Pediatr Infect Dis J"},{"key":"2019111507201639400_dkz358-B8","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1086\/597582","article-title":"Prospective, randomized trial of 10 days versus 30 days of antimicrobial treatment, including a short-term course of parenteral therapy, for childhood septic arthritis","volume":"48","author":"Peltola","year":"2009","journal-title":"Clin Infect Dis"},{"key":"2019111507201639400_dkz358-B9","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1097\/INF.0000000000001635","article-title":"Bone and joint infections","volume":"36","author":"Saavedra-Lozano","year":"2017","journal-title":"Pediatr Infect Dis J"},{"key":"2019111507201639400_dkz358-B10","doi-asserted-by":"crossref","first-page":"e2885.","DOI":"10.1097\/MD.0000000000002885","article-title":"A retrospective case-series of children with bone and joint infection from Northern Australia","volume":"95","author":"Brischetto","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"2019111507201639400_dkz358-B11","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/INF.0b013e31824657dd","article-title":"Management of osteoarticular infections caused by Staphylococcus aureus is similar to that of other etiologies: analysis of 199 staphylococcal bone and joint infections","volume":"31","author":"Paakkonen","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"2019111507201639400_dkz358-B12","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/INF.0000000000001753","article-title":"Analysis of invasive community-acquired methicillin-susceptible Staphylococcus aureus infections during a period of declining community acquired methicillin-resistant Staphylococcus aureus infections at a large children's hospital","volume":"37","author":"Hult\u00e9n","year":"2018","journal-title":"Pediatr Infect Dis J"},{"key":"2019111507201639400_dkz358-B13","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1097\/BPO.0b013e3181d4732f","article-title":"Kingella kingae osteoarticular infections in young children: clinical features and contribution of a new specific real-time PCR assay to the diagnosis","volume":"30","author":"Ceroni","year":"2010","journal-title":"J Pediatr Orthop"},{"key":"2019111507201639400_dkz358-B14","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/01.inf.0000259954.88139.f4","article-title":"Specific real-time polymerase chain reaction places Kingella kingae as the most common cause of osteoarticular infections in young children","volume":"26","author":"Chometon","year":"2007","journal-title":"Pediatr Infect Dis J"},{"key":"2019111507201639400_dkz358-B15","doi-asserted-by":"crossref","first-page":"17.","DOI":"10.1186\/s12880-015-0057-0","article-title":"Concomitant septic arthritis and osteomyelitis of the hip in young children; a new pathophysiological hypothesis suggested by MRI enhancement pattern","volume":"15","author":"Merlini","year":"2015","journal-title":"BMC Med Imaging"},{"key":"2019111507201639400_dkz358-B16","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S1684-1182(10)60051-5","article-title":"Acute community-acquired osteoarticular infections in children: high incidence of concomitant bone and joint involvement","volume":"43","author":"Chen","year":"2010","journal-title":"J Microbiol Immunol Infect"},{"key":"2019111507201639400_dkz358-B17","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.2214\/AJR.14.12891","article-title":"Septic arthritis in children: frequency of coexisting unsuspected osteomyelitis and implications on imaging work-up and management","volume":"204","author":"Monsalve","year":"2015","journal-title":"AJR Am J Roentgenol"},{"key":"2019111507201639400_dkz358-B18","volume-title":"R\u00e9f\u00e9rentiel en Microbiologie M\u00e9dicale","year":"2015","edition":"5th edn"},{"key":"2019111507201639400_dkz358-B19","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1586\/14737159.2015.1105132","article-title":"What to expect from molecular tools for non-documented pediatric infectious diseases","volume":"15","author":"Filleron","year":"2015","journal-title":"Expert Rev Mol Diagn"},{"key":"2019111507201639400_dkz358-B20","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.arcped.2011.05.015","article-title":"Antibiotic therapy of bone and joint infections in children: recent changes","volume":"18","author":"Lorrot","year":"2011","journal-title":"Arch Pediatr"},{"key":"2019111507201639400_dkz358-B21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1046\/j.1440-1754.2002.00007.x","article-title":"Duration of antibiotics in children with osteomyelitis and septic arthritis","volume":"38","author":"Vinod","year":"2002","journal-title":"J Paediatr Child Health"},{"key":"2019111507201639400_dkz358-B22","doi-asserted-by":"crossref","first-page":"241.","DOI":"10.1186\/s12891-015-0702-3","article-title":"A systematic review and meta-analysis regarding the use of corticosteroids in septic arthritis","volume":"16","author":"Farrow","year":"2015","journal-title":"BMC Musculoskelet Disord"},{"key":"2019111507201639400_dkz358-B23","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/jpids\/pis108","article-title":"Significance of negative cultures in the treatment of acute hematogenous bone and joint infections in children","volume":"2","author":"P\u00e4\u00e4kk\u00f6nen","year":"2013","journal-title":"J Pediatric Infect Dis Soc"},{"key":"2019111507201639400_dkz358-B24","doi-asserted-by":"crossref","first-page":"e00084","DOI":"10.1128\/CMR.00084-17","article-title":"Staphylococcal osteomyelitis: disease progression, treatment challenges, and future directions","volume":"31","author":"Kavanagh","year":"2018","journal-title":"Clin Microbiol Rev"},{"key":"2019111507201639400_dkz358-B25","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1097\/BPO.0b013e3181ab472d","article-title":"Prospectives evaluation of a shortened regimen of treatment for acute osteomyelitis and septic arthritis in children","volume":"29","author":"Jagodzinski","year":"2009","journal-title":"J Pediatr Orthop"},{"key":"2019111507201639400_dkz358-B26","first-page":"374","article-title":"Osteoarticular infections in Belgian children: a survey of clinical, biological, radiological and microbiological data","volume":"74","author":"Rasmont","year":"2008","journal-title":"Acta Orthop Belg"},{"key":"2019111507201639400_dkz358-B27","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/clm.12031","article-title":"Prospective survey of acute osteoarticular infections in a French paediatric orthopedic surgery unit","volume":"19","author":"Ferroni","year":"2013","journal-title":"Clin Microbiol Infect"},{"key":"2019111507201639400_dkz358-B28","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1099\/jmm.0.000026","article-title":"Microbiological characteristics of acute osteoarticular infections in children","volume":"64","author":"Russell","year":"2015","journal-title":"J Med Microbiol"},{"key":"2019111507201639400_dkz358-B29","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.otsr.2010.10.005","article-title":"Microbiological profile of haematogenous osteoarticular infections in children","volume":"97","author":"Trifa","year":"2011","journal-title":"Orthop Traumatol Surg Res"},{"key":"2019111507201639400_dkz358-B30","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/archdischild-2016-310594","article-title":"Arthritis in children: comparison of clinical and biological characteristics of septic arthritis and juvenile idiopathic arthritis","volume":"102","author":"Aupiais","year":"2017","journal-title":"Arch Dis Child"},{"key":"2019111507201639400_dkz358-B31","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s11999-009-0936-1","article-title":"Sensitivity of erythrocyte sedimentation rate and C-reactive protein in childhood bone and joint infections","volume":"468","author":"P\u00e4\u00e4kk\u00f6nen","year":"2010","journal-title":"Clin Orthop Relat Res"}],"container-title":["Journal of Antimicrobial Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/74\/12\/3579\/30795247\/dkz358.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jac\/article-pdf\/74\/12\/3579\/30795247\/dkz358.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T07:20:41Z","timestamp":1573802441000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jac\/article\/74\/12\/3579\/5559581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,3]]},"references-count":31,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,9,3]]},"published-print":{"date-parts":[[2019,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jac\/dkz358","relation":{},"ISSN":["0305-7453","1460-2091"],"issn-type":[{"value":"0305-7453","type":"print"},{"value":"1460-2091","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,12]]},"published":{"date-parts":[[2019,9,3]]}}}