{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:24:04Z","timestamp":1787009044933,"version":"build-2736575974"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,11,5]],"date-time":"2021-11-05T00:00:00Z","timestamp":1636070400000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"University of Queensland for Doctor of Philosophy candidature"},{"name":"Australian National Health and Medical Research Council Early Career Fellowships","award":["APP1158469"],"award-info":[{"award-number":["APP1158469"]}]},{"name":"NHMRC Early Career Fellowship","award":["GNT1157530"],"award-info":[{"award-number":["GNT1157530"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Carbapenem-resistant Acinetobacter (CRA) infections have been associated with increased morbidity and mortality in hospitalized patients. This systematic review and meta-analysis aimed to quantify the association between CRA infections and adverse clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Three databases (i.e. PubMed, EMBASE and Scopus) were searched for epidemiological studies that compared mortality, severe sepsis or shock, or bacteraemia among adult inpatients with CRA infections and those with carbapenem-susceptible Acinetobacter (CSA) infections. The pooled ORs for the three outcomes were estimated using the inverse variance heterogeneity model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirty-four studies were included. Patients with CRA infections had higher odds of mortality (31 studies, OR = 2.10, 95% CI: 1.58\u20132.79, I2=60.6%) and severe sepsis or septic shock (7 studies, OR = 1.51, 95% CI: 1.09\u20132.09, I2=0%) compared with CSA-infected patients. There was no difference in the odds of bacteraemia (four studies, OR = 1.39, 95% CI: 0.79\u20132.46, I2=38.1%). CRA-infected patients presented with worse comorbidity at admission (e.g. APACHE score) (eight studies, standardized mean difference = 0.25, 95% CI: \u22120.01 to 0.52) and had lower frequency of appropriate antibiotic therapy. Results were consistent when pooling 16 study-adjusted risk estimates for mortality. There was no difference in risk of mortality from CRA infection when compared across geographical regions, country income, median year of enrolment and day of mortality from infection onset.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CRA-infected patients had worse clinical outcomes. This might be due to delay in appropriate antibiotic therapy, patients being sicker at admission and CRA strains potentially being more virulent than CSA strains. Improving appropriateness of antibiotic therapy in CRA-infected patients could reduce adverse clinical outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jacamr\/dlab157","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T09:21:40Z","timestamp":1632993700000},"source":"Crossref","is-referenced-by-count":13,"title":["Adverse clinical outcomes associated with carbapenem-resistant\n                    <i>Acinetobacter<\/i>\n                    (CRA) infections: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5803-3831","authenticated-orcid":false,"given":"Weiping","family":"Ling","sequence":"first","affiliation":[{"name":"University of Queensland, Faculty of Medicine, UQ Centre for Clinical Research, Herston, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Furuya-Kanamori","sequence":"additional","affiliation":[{"name":"University of Queensland, Faculty of Medicine, UQ Centre for Clinical Research, Herston, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Ezure","sequence":"additional","affiliation":[{"name":"University of Queensland, Faculty of Medicine, UQ Centre for Clinical Research, Herston, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-0345","authenticated-orcid":false,"given":"Patrick N A","family":"Harris","sequence":"additional","affiliation":[{"name":"University of Queensland, Faculty of Medicine, UQ Centre for Clinical Research, Herston, Brisbane, Australia"},{"name":"Central Microbiology, Pathology Queensland, Royal Brisbane & Women\u2019s Hospital, Herston, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2079-4437","authenticated-orcid":false,"given":"David L","family":"Paterson","sequence":"additional","affiliation":[{"name":"University of Queensland, Faculty of Medicine, UQ Centre for Clinical Research, Herston, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,5]]},"reference":[{"key":"2021110504091702300_dlab157-B1","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1086\/500202","article-title":"The epidemiology and control of Acinetobacter baumannii in health care facilities","volume":"42","author":"Fournier","year":"2006","journal-title":"Clin Infect Dis"},{"key":"2021110504091702300_dlab157-B2","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1128\/JCM.38.11.4086-4095.2000","article-title":"Emergence and rapid spread of carbapenem resistance during a large and sustained hospital outbreak of multiresistant Acinetobacter baumannii","volume":"38","author":"Corbella","year":"2000","journal-title":"J Clin Microbiol"},{"key":"2021110504091702300_dlab157-B3","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1128\/AAC.00116-06","article-title":"Multicity outbreak of carbapenem-resistant Acinetobacter baumannii isolates producing the carbapenemase OXA-40","volume":"50","author":"Lolans","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"2021110504091702300_dlab157-B4","author":"CDC","year":"2019"},{"key":"2021110504091702300_dlab157-B5","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1128\/CMR.00058-07","article-title":"Acinetobacter baumannii: emergence of a successful pathogen","volume":"21","author":"Peleg","year":"2008","journal-title":"Clin Microbiol Rev"},{"key":"2021110504091702300_dlab157-B6","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1111\/j.1469-0691.2006.01456.x","article-title":"Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology","volume":"12","author":"Poirel","year":"2006","journal-title":"Clin Microbiol Infect"},{"key":"2021110504091702300_dlab157-B7","first-page":"e01110","article-title":"New treatment options against carbapenem-resistant Acinetobacter baumannii infections","volume":"63","author":"Isler","year":"2018","journal-title":"Antimicrob Agents Chemother"},{"key":"2021110504091702300_dlab157-B8","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/1469-0691.12363","article-title":"Carbapenem resistance and mortality in patients with Acinetobacter baumannii infection: systematic review and meta-analysis","volume":"20","author":"Lemos","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"2021110504091702300_dlab157-B9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1093\/jac\/dkp428","article-title":"Global spread of carbapenem-resistant Acinetobacter baumannii","volume":"65","author":"Higgins","year":"2010","journal-title":"J Antimicrob Chemother"},{"key":"2021110504091702300_dlab157-B10","doi-asserted-by":"crossref","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"2021110504091702300_dlab157-B11","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3201\/eid2007.121004","article-title":"Deaths attributable to carbapenem-resistant Enterobacteriaceae infections","volume":"20","author":"Falagas","year":"2014","journal-title":"Emerg Infect Dis"},{"key":"2021110504091702300_dlab157-B12","doi-asserted-by":"crossref","first-page":"ofy150","DOI":"10.1093\/ofid\/ofy150","article-title":"Association between carbapenem resistance and mortality among adult, hospitalized patients with serious infections due to Enterobacteriaceae: results of a systematic literature review and meta-analysis","volume":"5","author":"Martin","year":"2018","journal-title":"Open Forum Infect Dis"},{"key":"2021110504091702300_dlab157-B13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12941-017-0191-3","article-title":"Systematic review and meta-analysis of mortality of patients infected with carbapenem-resistant Klebsiella pneumoniae","volume":"16","author":"Xu","year":"2017","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"2021110504091702300_dlab157-B14","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1017\/ice.2017.197","article-title":"Carbapenem resistance, initial antibiotic therapy, and mortality in Klebsiella pneumoniae bacteremia: a systematic review and meta-analysis","volume":"38","author":"Kohler","year":"2017","journal-title":"Infect Control Hosp Epidemiol"},{"key":"2021110504091702300_dlab157-B15","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan-a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst Rev"},{"key":"2021110504091702300_dlab157-B16","author":"Wells"},{"key":"2021110504091702300_dlab157-B17","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cct.2015.05.009","article-title":"Advances in the meta-analysis of heterogeneous clinical trials I: the inverse variance heterogeneity model","volume":"45","author":"Doi","year":"2015","journal-title":"Contemp Clin Trials"},{"key":"2021110504091702300_dlab157-B18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/XEB.0000000000000141","article-title":"A new improved graphical and quantitative method for detecting bias in meta-analysis","volume":"16","author":"Furuya-Kanamori","year":"2018","journal-title":"Int J Evid Based Healthc"},{"key":"2021110504091702300_dlab157-B19","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","article-title":"Measuring inconsistency in meta-analyses","volume":"327","author":"Higgins","year":"2003","journal-title":"BMJ"},{"key":"2021110504091702300_dlab157-B20","volume-title":"admetan: A New, Comprehensive Meta-Analysis Command","author":"Fisher"},{"key":"2021110504091702300_dlab157-B21","volume-title":"LFK: Stata Module to Compute LFK Index and Doi Plot for Detection of Publication Bias in Meta-Analysis","author":"Furuya-Kanamori","year":"2020"},{"key":"2021110504091702300_dlab157-B22","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ijantimicag.2007.06.026","article-title":"Exposure to quinolones is associated with carbapenem resistance among colistin-susceptible Acinetobacter baumannii blood isolates","volume":"30","author":"Kopterides","year":"2007","journal-title":"Int J Antimicrob Agents"},{"key":"2021110504091702300_dlab157-B23","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s10096-008-0473-y","article-title":"Bloodstream infection due to Acinetobacter spp: epidemiology, risk factors and impact of multi-drug resistance","volume":"27","author":"Wareham","year":"2008","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2021110504091702300_dlab157-B24","doi-asserted-by":"crossref","first-page":"66","DOI":"10.7883\/yoken.65.66","article-title":"Mortality attributable to carbapenem-resistant nosocomial Acinetobacter baumannii infections in a Turkish university hospital","volume":"65","author":"Aydemir","year":"2012","journal-title":"Jpn J Infect Dis"},{"key":"2021110504091702300_dlab157-B25","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1007\/s10156-013-0608-7","article-title":"Implications of postneurosurgical meningitis caused by carbapenem-resistant Acinetobacter baumannii","volume":"19","author":"Moon","year":"2013","journal-title":"J Infect Chemother"},{"key":"2021110504091702300_dlab157-B26","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1016\/j.ajic.2013.01.006","article-title":"Risk factors and mortality of patients with nosocomial carbapenem-resistant Acinetobacter baumannii pneumonia","volume":"41","author":"Zheng","year":"2013","journal-title":"Am J Infect Control"},{"key":"2021110504091702300_dlab157-B27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3947\/ic.2013.45.3.325","article-title":"Risk factors for mortality in patients with Acinetobacter baumannii bacteremia","volume":"45","author":"Park","year":"2013","journal-title":"Infect Chemother"},{"key":"2021110504091702300_dlab157-B28","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3109\/00365548.2012.724178","article-title":"Risk factors and outcomes in patients with carbapenem-resistant Acinetobacter infection","volume":"45","author":"Vitkauskiene","year":"2013","journal-title":"Scand J Infect Dis"},{"key":"2021110504091702300_dlab157-B29","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.jmii.2013.02.002","article-title":"Risk factors for imipenem-nonsusceptible Acinetobacter nosocomialis bloodstream infection","volume":"47","author":"Huang","year":"2014","journal-title":"J Microbiol Immunol Infect"},{"key":"2021110504091702300_dlab157-B30","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1097\/CCM.0000000000000125","article-title":"Risk factors and outcome analysis of Acinetobacter baumannii complex bacteremia in critical patients","volume":"42","author":"Lee","year":"2014","journal-title":"Crit Care Med"},{"key":"2021110504091702300_dlab157-B31","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/1469-0691.12251","article-title":"Impact of carbapenem resistance on clinical and economic outcomes among patients with Acinetobacter baumannii infection in Colombia","volume":"20","author":"Lemos","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"2021110504091702300_dlab157-B32","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1186\/s12879-014-0572-6","article-title":"Predictors of hospital mortality among septic ICU patients with Acinetobacter spp. bacteremia: a cohort study","volume":"14","author":"Shorr","year":"2014","journal-title":"BMC Infect Dis"},{"key":"2021110504091702300_dlab157-B33","doi-asserted-by":"crossref","first-page":"4172","DOI":"10.1128\/AAC.02992-14","article-title":"Clinical outcomes of hospital-acquired infection with Acinetobacter nosocomialis and Acinetobacter pittii","volume":"58","author":"Chusri","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"2021110504091702300_dlab157-B34","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.ejim.2009.05.005","article-title":"Factors influencing survival in patients with multi-drug-resistant Acinetobacter bacteraemia","volume":"20","author":"Metan","year":"2009","journal-title":"Eur J Intern Med"},{"key":"2021110504091702300_dlab157-B35","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1128\/AAC.02656-15","article-title":"Clinical and epidemiological significance of carbapenem resistance in Acinetobacter baumannii infections","volume":"60","author":"Tal-Jasper","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"2021110504091702300_dlab157-B36","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s10096-016-2895-2","article-title":"Acinetobacter baumannii bacteraemia in patients with haematological malignancy: a multicentre retrospective study from the Infection Working Party of Jiangsu Society of Hematology","volume":"36","author":"Wang","year":"2017","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"2021110504091702300_dlab157-B37","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13054-018-2013-1","article-title":"Epidemiology of sepsis in intensive care units in Turkey: a multicenter, point-prevalence study","volume":"22","author":"Baykara","year":"2018","journal-title":"Crit Care"},{"key":"2021110504091702300_dlab157-B38","doi-asserted-by":"crossref","first-page":"S146","DOI":"10.1093\/cid\/ciy686","article-title":"Microbial etiology and prognostic factors of ventilator-associated pneumonia: a multicenter retrospective study in Shanghai","volume":"67 Suppl 2","author":"Huang","year":"2018","journal-title":"Clin Infect Dis"},{"key":"2021110504091702300_dlab157-B39","doi-asserted-by":"crossref","first-page":"3150965","DOI":"10.1155\/2018\/3150965","article-title":"Determinants of mortality in patients with nosocomial Acinetobacter baumannii bacteremia in Southwest China: a five-year case-control study","volume":"2018","author":"Yang","year":"2018","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"2021110504091702300_dlab157-B40","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ijid.2019.05.004","article-title":"Prevalence and 30-day all-cause mortality of carbapenem-and colistin-resistant bacteraemia caused by Acinetobacter baumannii, Pseudomonas aeruginosa, and Klebsiella pneumoniae: description of a decade-long trend","volume":"85","author":"Balkhair","year":"2019","journal-title":"Int J Infect Dis"},{"key":"2021110504091702300_dlab157-B41","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.jmii.2019.03.004","article-title":"Clinical characteristics and outcomes of community and hospital-acquired Acinetobacter baumannii bacteremia","volume":"52","author":"Chusri","year":"2019","journal-title":"J Microbiol Immunol Infect"},{"key":"2021110504091702300_dlab157-B42","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1089\/mdr.2015.0032","article-title":"Characteristics and outcomes of Acinetobacter baumannii infections in critically ill patients with cancer: a matched case\u2013control study","volume":"21","author":"Nazer","year":"2015","journal-title":"Microb Drug Resist"},{"key":"2021110504091702300_dlab157-B43","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/jac\/dkl499","article-title":"Impact of imipenem resistance on mortality in patients with Acinetobacter bacteraemia","volume":"59","author":"Kwon","year":"2007","journal-title":"J Antimicrob Chemother"},{"key":"2021110504091702300_dlab157-B44","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1086\/502018","article-title":"The cost of antibiotic resistance: effect of resistance among Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, and Pseudomonas aeruginosa on length of hospital stay","volume":"23","author":"Cofsky","year":"2002","journal-title":"Infect Control Hosp Epidemiol"},{"key":"2021110504091702300_dlab157-B45","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1086\/648450","article-title":"Epidemiology and impact of imipenem resistance in Acinetobacter baumannii","volume":"30","author":"Lautenbach","year":"2009","journal-title":"Infect Control Hosp Epidemiol"},{"key":"2021110504091702300_dlab157-B46","first-page":"413","article-title":"Attributable mortality of imipenem-resistant nosocomial Acinetobacter baumannii bloodstream infection","volume":"92","author":"Jamulitrat","year":"2009","journal-title":"J Med Assoc Thai"},{"key":"2021110504091702300_dlab157-B47","doi-asserted-by":"crossref","first-page":"e1225","DOI":"10.1016\/j.ijid.2013.07.014","article-title":"Acinetobacter baumannii ventilator-associated pneumonia: epidemiology, clinical characteristics, and prognosis factors","volume":"17","author":"Chaari","year":"2013","journal-title":"Int J Infect Dis"},{"key":"2021110504091702300_dlab157-B48","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1099\/jmm.0.001222","article-title":"Prospective multi-center evaluation on risk factors, clinical characteristics and outcomes due to carbapenem resistance in Acinetobacter baumannii complex bacteraemia: experience from the Chinese Antimicrobial Resistance Surveillance of Nosocomial Infections (CARES) Network","volume":"69","author":"Liu","year":"2020","journal-title":"J Med Microbiol"},{"key":"2021110504091702300_dlab157-B49","doi-asserted-by":"crossref","first-page":"ofx176","DOI":"10.1093\/ofid\/ofx176","article-title":"Prevalence of carbapenem-resistant gram-negative infections in the United States predominated by Acinetobacter baumannii and Pseudomonas aeruginosa","volume":"4","author":"Cai","year":"2017","journal-title":"Open Forum Infect Dis"},{"key":"2021110504091702300_dlab157-B50","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s15010-010-0008-1","article-title":"Carbapenem-resistant versus carbapenem-susceptible Acinetobacter baumannii bacteremia in a Greek intensive care unit: risk factors, clinical features and outcomes","volume":"38","author":"Routsi","year":"2010","journal-title":"Infection"},{"key":"2021110504091702300_dlab157-B51","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1128\/AAC.01728-10","article-title":"Impact of carbapenem resistance and receipt of active antimicrobial therapy on clinical outcomes of Acinetobacter baumannii bloodstream infections","volume":"55","author":"Esterly","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"2021110504091702300_dlab157-B52","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.jfma.2011.07.004","article-title":"Mortality risk factors in patients with Acinetobacter baumannii ventilator-associated pneumonia","volume":"110","author":"Chang","year":"2011","journal-title":"J Formos Med Assoc"},{"key":"2021110504091702300_dlab157-B53","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1186\/1471-2334-12-351","article-title":"The influence of carbapenem resistance on mortality in solid organ transplant recipients with Acinetobacter baumannii infection","volume":"12","author":"de Gouv\u00eaa","year":"2012","journal-title":"BMC Infect Dis"},{"key":"2021110504091702300_dlab157-B54","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3346\/jkms.2012.27.5.471","article-title":"Risk factors for mortality in patients with carbapenem-resistant Acinetobacter baumannii bacteremia: impact of appropriate antimicrobial therapy","volume":"27","author":"Kim","year":"2012","journal-title":"J Korean Med Sci"},{"key":"2021110504091702300_dlab157-B55","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.jmii.2011.12.009","article-title":"Risk factors and clinical outcomes of patients with carbapenem-resistant Acinetobacter baumannii bacteremia","volume":"45","author":"Huang","year":"2012","journal-title":"J Microbiol Immunol Infect"},{"key":"2021110504091702300_dlab157-B56","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1046\/j.1469-0691.2002.00487.x","article-title":"Nosocomial bacteremia due to Acinetobacter baumannii: epidemiology, clinical features and treatment","volume":"8","author":"Cisneros","year":"2002","journal-title":"Clin Microbiol Infect"},{"key":"2021110504091702300_dlab157-B57","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1111\/j.1469-0691.2005.01227.x","article-title":"Clinical impact and pathogenicity of Acinetobacter","volume":"11","author":"Joly-Guillou","year":"2005","journal-title":"Clin Microbiol Infect"},{"key":"2021110504091702300_dlab157-B58","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nrmicro1789","article-title":"An increasing threat in hospitals: multidrug-resistant Acinetobacter baumannii","volume":"5","author":"Dijkshoorn","year":"2007","journal-title":"Nat Rev Microbiol"},{"key":"2021110504091702300_dlab157-B59","doi-asserted-by":"crossref","first-page":"e17027","DOI":"10.1371\/journal.pone.0017027","article-title":"Acinetobacter baumannii secretes cytotoxic outer membrane protein A via outer membrane vesicles","volume":"6","author":"Jin","year":"2011","journal-title":"PLoS One"},{"key":"2021110504091702300_dlab157-B60","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1586\/eri.13.21","article-title":"Carbapenem resistance in Acinetobacter baumannii: laboratory challenges, mechanistic insights and therapeutic strategies","volume":"11","author":"Abbott","year":"2013","journal-title":"Expert Rev Anti Infect Ther"},{"key":"2021110504091702300_dlab157-B61","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/cid\/civ227","article-title":"Editorial commentary: the new Acinetobacter equation: hypervirulence plus antibiotic resistance equals big trouble","volume":"61","author":"Paterson","year":"2015","journal-title":"Clin Infect Dis"},{"key":"2021110504091702300_dlab157-B62","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1016\/j.ajic.2019.03.003","article-title":"Predictors of mortality in patients infected with carbapenem-resistant Acinetobacter baumannii: a systematic review and meta-analysis","volume":"47","author":"Du","year":"2019","journal-title":"Am J Infect Control"},{"key":"2021110504091702300_dlab157-B63","doi-asserted-by":"crossref","first-page":"e0229416","DOI":"10.1371\/journal.pone.0229416","article-title":"Using comparative genomics to understand molecular features of carbapenem-resistant Acinetobacter baumannii from South Korea causing invasive infections and their clinical implications","volume":"15","author":"Kim","year":"2020","journal-title":"PLoS One"},{"key":"2021110504091702300_dlab157-B64","doi-asserted-by":"crossref","first-page":"21663","DOI":"10.18632\/oncotarget.24651","article-title":"Distribution of virulence-associated genes and antimicrobial susceptibility in clinical Acinetobacter baumannii isolates","volume":"9","author":"Liu","year":"2018","journal-title":"Oncotarget"},{"key":"2021110504091702300_dlab157-B65","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/cid\/civ225","article-title":"Fatal outbreak of an emerging clone of extensively drug-resistant Acinetobacter baumannii with enhanced virulence","volume":"61","author":"Jones","year":"2015","journal-title":"Clin Infect Dis"}],"container-title":["JAC-Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jacamr\/article-pdf\/3\/4\/dlab157\/41077144\/dlab157.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jacamr\/article-pdf\/3\/4\/dlab157\/41077144\/dlab157.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,10]],"date-time":"2023-01-10T15:48:38Z","timestamp":1673365718000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jacamr\/article\/doi\/10.1093\/jacamr\/dlab157\/6420880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,30]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,9,30]]}},"URL":"https:\/\/doi.org\/10.1093\/jacamr\/dlab157","relation":{},"ISSN":["2632-1823"],"issn-type":[{"value":"2632-1823","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12,1]]},"published":{"date-parts":[[2021,9,30]]},"article-number":"dlab157"}}