{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T21:39:46Z","timestamp":1790458786189,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Neonatal sepsis remains one of the leading causes of morbidity and mortality in neonates, especially in developing countries.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To determine the prevalence, common bacterial pathogens, and the antibiotic susceptibility pattern of neonatal sepsis at the Lagos University Teaching Hospital (LUTH), Lagos, Nigeria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a cross-sectional study of neonates who presented at the facility with symptoms and signs of sepsis from January 2017 to October 2017. Demographic and clinical data were extracted using a structured questionnaire. Blood culture, urine and CSF were collected and cultured on blood and MacConkey agar. Bacterial isolates were identified using Microbact 24E system and biochemical tests. Antibacterial susceptibility testing was done using the modified Kirby\u2013Bauer disc diffusion method.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Two hundred and ninety neonates were recruited during the study period. Seventy-three (25.2%) neonates had culture-proven sepsis. One (0.3%) neonate had meningitis and no neonates (0%) had confirmed urinary tract infection. Of the 73 neonates with positive blood cultures, 56 (76.7%) had early-onset sepsis and 17 (23.3%) had late-onset sepsis. Gram-negative bacilli accounted for 60.3% of all isolates. Predominantly isolated pathogens were Staphylococcus aureus (20.5%), CoNS (19.2%) and Klebsiella pneumoniae (13.7%). The isolates were most susceptible to levofloxacin and amikacin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Neonatal sepsis is still a huge burden in the newborn. S. aureus, CoNS and K. pneumoniae are the prevalent pathogens in the local facility, with good susceptibility to levofloxacin and amikacin. Maintaining regular antibiotic surveillance for appropriate empirical antibiotics is important as part of neonatal care.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jacamr\/dlac100","type":"journal-article","created":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T19:43:34Z","timestamp":1664567014000},"source":"Crossref","is-referenced-by-count":17,"title":["Antimicrobial susceptibility and neonatal sepsis in a tertiary care facility in Nigeria: a changing trend?"],"prefix":"10.1093","volume":"4","author":[{"given":"Nkoyo O","family":"Uwe","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Lagos University Teaching Hospital (LUTH) , Lagos , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7437-3211","authenticated-orcid":false,"given":"Beatrice N","family":"Ezenwa","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Lagos University Teaching Hospital (LUTH) , Lagos , Nigeria"},{"name":"Department of Paediatrics, College of Medicine University of Lagos , Lagos , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iretiola B","family":"Fajolu","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Lagos University Teaching Hospital (LUTH) , Lagos , Nigeria"},{"name":"Department of Paediatrics, College of Medicine University of Lagos , Lagos , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Oshun","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Lagos University Teaching Hospital (LUTH) , Lagos , Nigeria"},{"name":"Department of Medical Microbiology, College of Medicine University of Lagos , Lagos , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella T","family":"Chukwuma","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Lagos University Teaching Hospital (LUTH) , Lagos , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica C","family":"Ezeaka","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Lagos University Teaching Hospital (LUTH) , Lagos , Nigeria"},{"name":"Department of Paediatrics, College of Medicine University of Lagos , Lagos , Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"2022093015450201100_dlac100-B1","first-page":"333","article-title":"Epidemiology of neonatal sepsis and associated factors implicated: observational study at neonatal intensive care unit of Arsi University Teaching and Referral Hospital, South East Ethiopia","volume":"29","author":"Sorsa","year":"2019","journal-title":"Ethiop J Health Sci"},{"key":"2022093015450201100_dlac100-B2","first-page":"169","article-title":"Neonatal sepsis in Jordan: bacterial isolates and antibiotic susceptibility patterns","volume":"36","author":"Younis","year":"2011","journal-title":"Rawal Med J"},{"key":"2022093015450201100_dlac100-B3","first-page":"28298","article-title":"Neonatal sepsis in Nigeria 2: narrative review of epidemiology and socioeconomic factors","volume":"36","author":"Ogbara","year":"2021","journal-title":"Biomed J Sci Tech Res"},{"key":"2022093015450201100_dlac100-B4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/tropej\/fmu079","article-title":"Challenges in the diagnosis and management of neonatal sepsis","volume":"61","author":"Zea-Vera","year":"2015","journal-title":"J Trop Pediatr"},{"key":"2022093015450201100_dlac100-B5","first-page":"127","article-title":"Neonatal sepsis in a Nigerian tertiary hospital: clinical features, clinical outcome, aetiology and antibiotic susceptibility pattern","volume":"32","author":"Arowosegbe","year":"2017","journal-title":"South Afr J Infect Dis"},{"key":"2022093015450201100_dlac100-B6","volume-title":"Nigeria Every Newborn Action Plan: a Plan to End Preventable Newborn Deaths in Nigeria","author":"Federal Ministry of Health","year":"2016"},{"key":"2022093015450201100_dlac100-B7","doi-asserted-by":"crossref","first-page":"e10000213","DOI":"10.1371\/journal.pmed.1000213","article-title":"New approaches to preventing, diagnosing, and treating neonatal sepsis","volume":"7","author":"Edmond","year":"2010","journal-title":"PLoS Med"},{"key":"2022093015450201100_dlac100-B8","article-title":"Differences Between Screening and Diagnostic Tests and Case Finding","author":"Public Health Action Support Team.","year":"2017"},{"key":"2022093015450201100_dlac100-B9","doi-asserted-by":"crossref","first-page":"323","DOI":"10.3390\/antibiotics10030323","article-title":"Antibiotic resistance patterns of bacterial isolates from neonatal sepsis patients at University Hospital of Leipzig. 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