{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:24:03Z","timestamp":1787009043690,"version":"build-2736575974"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>High-quality systematic data on antimicrobial use in UK inpatient paediatric haematology-oncology services are lacking, despite this population being at high risk from antimicrobial exposure and resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We conducted a retrospective study to demonstrate how routinely collected electronic prescribing data can address this issue.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients and methods<\/jats:title>\n                    <jats:p>This retrospective study describes and compares IV antibiotic consumption between two UK paediatric haematology-oncology inpatient units, between 2018 and 2022. Both sites provide similar services and receive proactive antimicrobial stewardship input. Data were extracted from each site\u2019s antimicrobial surveillance system, which report monthly days of therapy (DOT) per 100\u2005patient-days (PD). Consumption was reported for specific and total antibiotics. Trends were modelled using linear regression and autoregressive moving average models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Total IV antibiotic consumption at each site was similar. Median monthly DOT per 100\u2005PD were 25.9 (IQR: 22.1\u201334.0) and 29.4 (24.2\u201334.9). Total antibiotic use declined at both sites, with estimated annual yearly reductions of 3.52\u2005DOT per 100\u2005PD (95% CI: 0.46\u20136.59) and 2.57 (1.30\u20133.85). Absolute consumption was similar for carbapenems, piperacillin\/tazobactam and aminoglycosides, whilst ceftriaxone and teicoplanin demonstrated approximately 3-fold relative differences in median monthly consumption. Meropenem, piperacillin\/tazobactam, teicoplanin, vancomycin and gentamicin all demonstrated statistically significant reductions in use over time at either one or both sites, although this was most marked for piperacillin\/tazobactam and vancomycin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Routinely collected electronic prescribing data can aid benchmarking of antibiotic use in paediatric haematology-oncology inpatients, highlighting areas to target stewardship strategies, and evaluating their impact. This approach should be rolled out nationally, and to other high-risk groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jacamr\/dlad142","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T10:49:26Z","timestamp":1701859766000},"source":"Crossref","is-referenced-by-count":2,"title":["The use of routinely collected electronic prescribing data to benchmark intravenous antibiotic use between two tertiary paediatric haematology-oncology inpatient units: a retrospective study"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8166-8680","authenticated-orcid":false,"given":"Samuel","family":"Channon-Wells","sequence":"first","affiliation":[{"name":"Department of Paediatrics, Oxford University Hospitals NHS Foundation Trust , Oxford , UK"},{"name":"Department of Infectious Disease, Imperial College London , London , UK"},{"name":"School of Medicine, St Mary\u2019s Hospital , Praed Street London W2 1NY, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"H\u00e9rin","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Oxford University Hospitals NHS Foundation Trust , Oxford , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismail","family":"Elbeshlawi","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Oxford University Hospitals NHS Foundation Trust , Oxford , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliet","family":"Gray","sequence":"additional","affiliation":[{"name":"Department of Paediatric Infectious Diseases and Immunology, University Hospital Southampton NHS Foundation Trust , Tremona Road , Southampton SO16 6YD, UK"},{"name":"Centre for Cancer Immunology, University of Southampton and Department of Paediatric Oncology, University Hospital Southampton NHS Foundation Trust , Southampton SO17 1BJ , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Paediatric Infectious Diseases and Immunology, University Hospital Southampton NHS Foundation Trust , Tremona Road , Southampton SO16 6YD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Paulus","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Oxford University Hospitals NHS Foundation Trust , Oxford , UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,28]]},"reference":[{"key":"2024022909274483100_dlad142-B1","doi-asserted-by":"crossref","first-page":"e1003208","DOI":"10.1371\/journal.pmed.1003208","article-title":"Variation in antibiotic prescription rates in febrile children presenting to emergency departments across Europe (MOFICHE): a multicentre observational 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