{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T23:40:17Z","timestamp":1778542817203,"version":"3.51.4"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007248","name":"MSF","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007248","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To describe the prevalence of common bacterial pathogens and antibiotic susceptibility patterns amongst advanced HIV disease (AHD) patients admitted between May 2019 and March 2021 to a M\u00e9decins Sans Fronti\u00e8res (MSF)-supported AHD inpatient unit in Bihar, India.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective analysis of routinely collected demographic, clinical and microbiological data. Antibacterial susceptibility testing was done by an accredited referral laboratory using the modified Kirby\u2013Bauer disc diffusion method.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 238 isolates from 577 patients were identified through culture testing. Patient median (IQR) age was 38 (31\u201345)\u2005years, and 75% were male. Predominant sample types included blood (600; 38%), urine (266; 17%) and sputum (178; 11%). Of the isolated bacteria, Escherichia coli (80; 13.9%) was the most prevalent, followed by Klebsiella pneumonia (54; 9.4%), Pseudomonas aeruginosa (22; 3.8%), Klebsiella oxytoca (10; 1.7%), Proteus mirabilis (9; 1.6%), and Acinetobacter baumannii (7; 1.2%). The resistance pattern showed that most bacterial isolates were highly resistant to commonly prescribed antibiotics such as third-generation cephalosporins, fluoroquinolones and co-trimoxazole. Most pathogens were moderately resistant to antibiotics from the WHO Watch group, such as meropenem and piperacillin\/tazobactam. In contrast, isolates were more susceptible to aminoglycosides, such as amikacin, gentamicin and nitrofurantoin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In Bihar, inpatients with AHD displayed a concerning array of antibiotic-resistant infections. This study provides a starting point from which further work on antimicrobial resistance in this vulnerable cohort of patients can be conducted.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jacamr\/dlad151","type":"journal-article","created":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T11:07:18Z","timestamp":1704193638000},"source":"Crossref","is-referenced-by-count":6,"title":["Antibiotic susceptibility patterns of pathogens isolated from hospitalized patients with advanced HIV disease (AHD) in Bihar, India"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1277-8170","authenticated-orcid":false,"given":"Vikash","family":"Kumar","sequence":"first","affiliation":[{"name":"Operational Centre Barcelona-Athens, M\u00e9decins Sans Fronti\u00e8res , New Delhi , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shreyas","family":"Murali","sequence":"additional","affiliation":[{"name":"Operational Centre Barcelona-Athens, M\u00e9decins Sans Fronti\u00e8res , Patna , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Goldberg","sequence":"additional","affiliation":[{"name":"Medical Department, M\u00e9decins Sans Fronti\u00e8res , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Alonso","sequence":"additional","affiliation":[{"name":"Medical Department, M\u00e9decins Sans Fronti\u00e8res , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Moret\u00f3-Planas","sequence":"additional","affiliation":[{"name":"Operational Centre Barcelona-Athens, M\u00e9decins Sans Fronti\u00e8res , Barcelona , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Reid","sequence":"additional","affiliation":[{"name":"Op\u00e9rationnel Research Unit, M\u00e9decins Sans Fronti\u00e8res , Luxembourg , Luxembourg"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Harshana","sequence":"additional","affiliation":[{"name":"Operational Centre Barcelona-Athens, M\u00e9decins Sans Fronti\u00e8res , New Delhi , India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7886-8633","authenticated-orcid":false,"given":"Sakib","family":"Burza","sequence":"additional","affiliation":[{"name":"Operational Centre Barcelona-Athens, M\u00e9decins Sans Fronti\u00e8res , New Delhi , India"},{"name":"London School of Hygiene and Tropical Medicine , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6788-2835","authenticated-orcid":false,"given":"Raman","family":"Mahajan","sequence":"additional","affiliation":[{"name":"Operational Centre Barcelona-Athens, M\u00e9decins Sans Fronti\u00e8res , New Delhi , India"},{"name":"Care and Public Health Research Institute, Maastricht 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