{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:04:18Z","timestamp":1753877058591,"version":"3.41.2"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Special Programme for Research and Training in Tropical Diseases at the World Health Organization"},{"DOI":"10.13039\/501100005850","name":"International Union Against Tuberculosis and Lung Disease","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005850","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008196","name":"Med\u00e9cins Sans Fronti\u00e8res","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008196","id-type":"DOI","asserted-by":"publisher"}]},{"name":"MSF specifically for Antimicrobial Resistance research"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Antimicrobial resistance (AMR) is an urgent global health concern, especially in countries facing instability or conflicts, with compromised healthcare systems. M\u00e9decins Sans Fronti\u00e8res (MSF) established an acute trauma hospital in Aden, Yemen, treating mainly war-wounded civilians, and implemented an antimicrobial stewardship (AMS) programme. This study aimed to describe clinical characteristics and identify antibiotic susceptibility patterns representative of patients treated with antibiotics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Retrospective cross-sectional study using routinely collected data from all patients treated with antibiotics in the MSF-Aden Acute Trauma hospital between January 2018 and June 2021. Routine clinical data from patients\u2019 files was entered into an AMS electronic database and microbiological data were entered into WHONET. Both databases were imported and merged in REDCap and analysed using RStudio.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Three hundred and sixty-three of 481 (75%) included patients were injured by violence-related trauma. Most were men aged 19\u201345 years (n\u200a=\u200a331; 68.8%). In total, 598 infections were diagnosed and treated. MDR organisms were identified in 362 (60.5%) infections in 311 (65%) patients. Skin and soft-tissue infections (SSTIs) (n\u200a=\u200a143; 24%) were the most common, followed by osteomyelitis (n\u200a=\u200a125; 21%) and intra-abdominal-infections (IAIs) (n\u200a=\u200a116; 19%), and 111 (19%) secondary bloodstream infections were identified. Escherichia coli was the most frequently identified pathogen, causing IAI (n\u200a=\u200a87; 28%) and SSTI (n\u200a=\u200a43; 16%), while Staphylococcus aureus caused mainly osteomyelitis (n\u200a=\u200a84; 19%). Most Gram-negatives were ESBL producers, including E. coli (n\u200a=\u200a193; 81.4%), Klebsiella pneumoniae (n\u200a=\u200a72; 77.4%) and Enterobacter cloacae (n\u200a=\u200a39; 50%) while most S. aureus were methicillin resistant (n\u200a=\u200a93; 72.6%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>High rates of MDR were found. This information will facilitate a comprehensive review of the empirical antibiotic treatment guidelines.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jacamr\/dlae024","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T23:57:29Z","timestamp":1709683049000},"source":"Crossref","is-referenced-by-count":9,"title":["Antibiotic susceptibility patterns at the M\u00e9decins Sans Fronti\u00e8res (MSF) Acute Trauma Hospital in Aden, Yemen: a retrospective study from January 2018 to June 2021"],"prefix":"10.1093","volume":"6","author":[{"given":"Hussein","family":"Almehdar","sequence":"first","affiliation":[{"name":"M\u00e9decins Sans Fronti\u00e8res\u2014Operational Centre Paris (MSFOCP), Acute Trauma Hospital , Aden , 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