{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T05:07:14Z","timestamp":1785215234051,"version":"3.55.0"},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T00:00:00Z","timestamp":1719964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Thomas Mackey Center for Infectious Disease Research"},{"name":"Ascension St John Hospital Department of Medicine"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Rhodomyrtone is a novel plant-derived antibiotic compound originally isolated from Rhodomyrtus tomentosa leaf extract.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the activity of rhodomyrtone against a group of MRSA strains, including isolates with reduced susceptibility or resistance to vancomycin, daptomycin, linezolid and ceftaroline.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Broth microdilution testing was used to determine the MICs and MBCs of rhodomyrtone, fosfomycin, vancomycin, daptomycin, linezolid and ceftaroline.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>ROM had an MIC90 of 1 mg\/L against 110 strains of MRSA from blood isolates as well as for all other isolates that were daptomycin resistant, VISA, VRSA or LRSA. The MBC90 were 4 mg\/L across all groups tested. Among all S. aureus groups tested the ROM MBC did not exceed 8 mg\/L.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Rhodomyrtone demonstrated excellent activity against MRSA as well as isolates with resistance or reduced activity to other anti-MRSA drugs including vancomycin, daptomycin and linezolid. Rhodomyrtone may have potential clinical utility when treating patients with infections caused by MRSA including those with reduced susceptibility to first-line anti-MRSA antimicrobial agents.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jacamr\/dlae097","type":"journal-article","created":{"date-parts":[[2024,7,3]],"date-time":"2024-07-03T11:36:42Z","timestamp":1720006602000},"source":"Crossref","is-referenced-by-count":4,"title":["Rhodomyrtone: a new anti-<i>Staphylococcus aureus<\/i> agent against resistant strains"],"prefix":"10.1093","volume":"6","author":[{"given":"Louis D","family":"Saravolatz","sequence":"first","affiliation":[{"name":"Department of Medicine, Ascension-St John Hospital , Grosse Pointe Woods, MI , USA"},{"name":"Department of Medicine, Thomas Mackey Center for Infectious Disease Research , Grosse Pointe Woods MI , USA"},{"name":"Department of Medicine, Wayne State University School of Medicine , Detroit, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Pawlak","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ascension-St John Hospital , Grosse Pointe Woods, MI , USA"},{"name":"Department of Medicine, Thomas Mackey Center for Infectious Disease Research , Grosse Pointe Woods MI , USA"},{"name":"Department of Medicine, Wayne State University School of Medicine , Detroit, MI , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,7,3]]},"reference":[{"key":"2024083008103739400_dlae097-B1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.3390\/antibiotics10050543","article-title":"Rhodomyrtone accumulates in bacterial cell wall and cell membrane and inhibits the synthesis of multiple cellular macromolecules in epidemic methicillin-resistant Staphylococcus aureus","volume":"10","author":"Nwabor","year":"2021","journal-title":"Antibiotics (Basel)"},{"key":"2024083008103739400_dlae097-B2","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.micpath.2018.12.019","article-title":"Rhodomyrtone decreases Staphylococcus aureus SigB activity during exponentially growing phase and inhibits haemolytic activity within membrane vesicles","volume":"128","author":"Mitsuwan","year":"2019","journal-title":"Microb Pathog"},{"key":"2024083008103739400_dlae097-B3","doi-asserted-by":"crossref","first-page":"e0383321","DOI":"10.1128\/mbio.03833-21","article-title":"Molecular basis of rhodomyrtone resistance in Staphylococcus aureus","volume":"13","author":"Huang","year":"2021","journal-title":"mBio"},{"key":"2024083008103739400_dlae097-B4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/cid\/cir034","article-title":"Clinical practice guidelines by the Infectious Diseases Society of America for the treatment of methicillin-resistant Staphylococcus aureus infections in adults and children","volume":"52","author":"Liu","year":"2011","journal-title":"Clin Infect Dis"},{"key":"2024083008103739400_dlae097-B5","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/jac\/dkac380","article-title":"In vitro activity of fosfomycin alone and in combination against Staphylococcus aureus with reduced susceptibility or resistance to methicillin, vancomycin, daptomycin or linezolid","volume":"78","author":"Saravolatz","year":"2023","journal-title":"J Antimicrob Chemother"},{"key":"2024083008103739400_dlae097-B6","author":"CLSI"},{"key":"2024083008103739400_dlae097-B7","author":"CLSI"},{"key":"2024083008103739400_dlae097-B8","author":"CLSI"},{"key":"2024083008103739400_dlae097-B9","author":"EUCAST"},{"key":"2024083008103739400_dlae097-B10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1099\/jmm.0.049205-0","article-title":"Antibacterial mechanisms of rhodomyrtone against important hospital-acquired antibiotic-resistant pathogenic bacteria","volume":"62","author":"Leejae","year":"2013","journal-title":"J Med Microbiol"},{"key":"2024083008103739400_dlae097-B11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.3390\/antibiotics10020108","article-title":"Rhodomyrtone as a new natural antibiotic isolated from Rhodomyrtus tomentosa leaf extract: a clinical application in the management of acne vulgaris","volume":"10","author":"Wunnoo","year":"2021","journal-title":"Antibiotics (Basel)"}],"container-title":["JAC-Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jacamr\/article-pdf\/6\/4\/dlae097\/58875525\/dlae097.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jacamr\/article-pdf\/6\/4\/dlae097\/58875525\/dlae097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T12:40:06Z","timestamp":1725021606000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jacamr\/article\/doi\/10.1093\/jacamr\/dlae097\/7704610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,3]]},"references-count":11,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jacamr\/dlae097","relation":{},"ISSN":["2632-1823"],"issn-type":[{"value":"2632-1823","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,8]]},"published":{"date-parts":[[2024,7,3]]},"article-number":"dlae097"}}