{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T18:47:56Z","timestamp":1788893276940,"version":"build-2803163510"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes of Taiwan","doi-asserted-by":"crossref","award":["IV-111-PP-22"],"award-info":[{"award-number":["IV-111-PP-22"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes of Taiwan","doi-asserted-by":"crossref","award":["IV-112-PP-15"],"award-info":[{"award-number":["IV-112-PP-15"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["104-TDU-B-211-113001"],"award-info":[{"award-number":["104-TDU-B-211-113001"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["105-TDU-B-211-133015"],"award-info":[{"award-number":["105-TDU-B-211-133015"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["106-TDU-B-211-113002"],"award-info":[{"award-number":["106-TDU-B-211-113002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["107-TDU-B-211-123002"],"award-info":[{"award-number":["107-TDU-B-211-123002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["108-TDU-B-211-133002"],"award-info":[{"award-number":["108-TDU-B-211-133002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["109-TDU-B-211-114002"],"award-info":[{"award-number":["109-TDU-B-211-114002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["110-TDU-B-211-124002"],"award-info":[{"award-number":["110-TDU-B-211-124002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008903","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["111-TDU-B-211-134002"],"award-info":[{"award-number":["111-TDU-B-211-134002"]}],"id":[{"id":"10.13039\/100008903","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aimed to investigate the prevalence and characteristics of Aspergillus lentulus clinical and environmental isolates in Taiwan.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Aspergillus isolates obtained from patients at three hospitals and from 530 soil samples across Taiwan were screened. A. lentulus, confirmed by calmodulin sequencing, was subjected to antifungal susceptibility testing and cyp51A analyses. Soil samples yielding A. lentulus were analysed for residues of 25 azole fungicides.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Nine A. lentulus isolates were identified, which included seven (1.2%, 7\/601) isolates from three antifungal-na\u00efve patients out of 601 Aspergillus section Fumigati clinical isolates and two (0.3%, 2\/659) isolates out of 659 Aspergillus soil isolates. All isolates developed white colonies and failed to grow at 48\u00b0C. They were susceptible to anidulafungin but showed reduced susceptibility to amphotericin B (AmB), voriconazole and azole fungicides. One heart transplant recipient with proven invasive pulmonary aspergillosis (IPA) initially showed suboptimal response to voriconazole monotherapy but was cured with a combination of voriconazole\u2013caspofungin, liposomal AmB (LAmB)\u2013caspofungin, along with surgery, followed by voriconazole maintenance therapy. Among two critically ill patients with probable IPA, one survived with micafungin, while the other died of aspergillosis despite sequential isavuconazole and LAmB monotherapy. Clinical and environmental isolates sharing identical Cyp51A sequence are identified, matching the Cyp51A sequence of A. lentulus NIID0096. Flusilazole (0.0009\u2005mg\/kg) was detected in one soil sample.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study raises concerns about health threat posed by human pathogenic A. lentulus originating from natural environments and underscores the need for increased clinical and laboratory vigilance regarding A. lentulus infections.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jacamr\/dlae138","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T12:16:03Z","timestamp":1724933763000},"source":"Crossref","is-referenced-by-count":5,"title":["Emerging <i>Aspergillus lentulus<\/i> infections in Taiwan: clinical and environmental surveillance"],"prefix":"10.1093","volume":"6","author":[{"given":"Pao-Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital , Taipei , Taiwan"},{"name":"Graduate Institute of Clinical Medicine, National Taiwan University College of Medicine , Taipei , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0235-9060","authenticated-orcid":false,"given":"Chien-Ming","family":"Chao","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying , Tainan , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chwan-Yau","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Surgery, Kaohsiung Medical University Memorial Hospital and College of Medicine Kaohsiung Medical University , Kaohsiung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yau-Lin","family":"Tseng","sequence":"additional","affiliation":[{"name":"Division of Thoracic Surgery, Department of Surgery, National Cheng Kung University Hospital , College of Medicine, National Cheng Kung University, Tainan , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po-Lin","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0312-0628","authenticated-orcid":false,"given":"Jun-Neng","family":"Roan","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Surgery, Department of Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Lun","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Medicine, College of Medicine, Fu Jen Catholic University , New Taipei City , Taiwan"},{"name":"Department of Critical Care Medicine, Fu Jen Catholic University Hospital, Fu Jen Catholic University , New Taipei City , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien","family":"Chu","sequence":"additional","affiliation":[{"name":"Residue Control Division, Agricultural Chemicals Research Institute, Ministry of Agriculture , Taichung , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9607-9088","authenticated-orcid":false,"given":"Chi-Jung","family":"Wu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan , Taiwan"},{"name":"Division of Infectious Diseases, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes , Miaoli , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsuan-Chen","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes , Miaoli , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-I","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes , Miaoli , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pui-Ching","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes , Miaoli , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1816-9010","authenticated-orcid":false,"given":"Yee-Chun","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, National Taiwan University Hospital , Taipei , Taiwan"},{"name":"Division of Infectious Diseases, National Institute of Infectious Diseases and Vaccinology, National Health Research Institutes , Miaoli , Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"2024082908512325500_dlae138-B1","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1128\/AAC.48.4.1197-1203.2004","article-title":"Aspergillus fumigatus variant with decreased susceptibility to multiple antifungals","volume":"48","author":"Balajee","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl 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