{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T21:45:45Z","timestamp":1782423945830,"version":"3.54.5"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"S\u00f8rlandet Hospital"},{"name":"Arctic University of Norway"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Outpatient parenteral antimicrobial therapy (OPAT) is safe, effective and increasingly available. While OPAT in Norwegian healthcare has been rare, a new continuous ambulatory delivery device (CADD) allowing multiple daily dosing treatments has been innovated making OPAT more accessible.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To describe the clinical outcome and safety using CADD in an OPAT setting.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Adult patients in need of parenteral antibiotic treatment were offered OPAT and discharged with a programmable digital infusion pump allowing multiple daily dosings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Altogether, 170 patients were included in the study, among which 21% of all patients (36 of 170) were readmitted to hospital while receiving OPAT or within 30\u2005days after end of intravenous antibiotics. None of the 170 patients died due to OPAT and allergies were not noticeable as a problem.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We have developed a safe and clinically effective programme offering OPAT in accordance with Norwegian antibiotic treatment guidelines.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jacamr\/dlae155","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T10:18:55Z","timestamp":1728901135000},"source":"Crossref","is-referenced-by-count":6,"title":["Outpatient parenteral antimicrobial therapy (OPAT) using a continuous ambulatory delivery device (CADD) allowing treatment with multiple daily doses: a brief report of a Norwegian experience"],"prefix":"10.1093","volume":"6","author":[{"given":"Vegard","family":"Skogen","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway , PO Box 6050 Langnes, Troms\u00f8 N-9037 ,","place":["Norway"]},{"name":"Department of Infectious Diseases, Division of Internal Medicine, University Hospital of North Norway , Troms\u00f8, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Helleren","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, S\u00f8rlandet Hospital , Kristiansand ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne Giske","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, S\u00f8rlandet Hospital , Kristiansand ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Opsal","sequence":"additional","affiliation":[{"name":"Department of Health and Nursing Science, University of Agder , Kristiansand ,","place":["Norway"]},{"name":"Department of Clinical Research, S\u00f8rlandet Hospital , Kristiansand ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frode","family":"Gallefoss","sequence":"additional","affiliation":[{"name":"Department of Clinical Research, S\u00f8rlandet Hospital , Kristiansand ,","place":["Norway"]},{"name":"Faculty of Medicine, University of Bergen , Bergen ,","place":["Norway"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,14]]},"reference":[{"key":"2024103013305080200_dlae155-B1","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Antimicrobial Resistance Collaborators","year":"2022","journal-title":"Lancet"},{"key":"2024103013305080200_dlae155-B2","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.1093\/cid\/ciw118","article-title":"Implementing an antibiotic stewardship program: guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America","volume":"62","author":"Barlam","year":"2016","journal-title":"Clin Infect Dis"},{"key":"2024103013305080200_dlae155-B3","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlz026","article-title":"Updated good practice recommendations for outpatient parenteral antimicrobial therapy (OPAT) in adults and children in the UK","volume":"1","author":"Chapman","year":"2019","journal-title":"JAC Antimicrob Resist"},{"key":"2024103013305080200_dlae155-B4","doi-asserted-by":"publisher","first-page":"e1","DOI":"10.1093\/cid\/ciy867","article-title":"2018 Infectious Diseases Society of America clinical practice guideline for the management of outpatient parenteral antimicrobial therapy","volume":"68","author":"Norris","year":"2019","journal-title":"Clin Infect Dis"},{"key":"2024103013305080200_dlae155-B5","author":"The Directorate of Health"},{"key":"2024103013305080200_dlae155-B6","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1111\/bjh.15249","article-title":"Systematic patient involvement for homebased outpatient administration of complex chemotherapy in acute leukemia and lymphoma","volume":"181","author":"Fridthjof","year":"2018","journal-title":"Br J Haematol"},{"key":"2024103013305080200_dlae155-B7","doi-asserted-by":"publisher","first-page":"106756","DOI":"10.1016\/j.leukres.2021.106756","article-title":"A national Danish proof of concept on feasibility and safety of home-based intensive chemotherapy in patients with acute myeloid leukemia","volume":"112","author":"N\u00f8rskov","year":"2022","journal-title":"Leuk Res"},{"key":"2024103013305080200_dlae155-B8","doi-asserted-by":"publisher","first-page":"1","DOI":"10.7557\/14.6742","article-title":"Hjemmebehandling med intraven\u00f8s antibiotika. Gjennomf\u00f8rbarhet og pasienters erfaringer","volume":"19","author":"Jacobsen","year":"2023","journal-title":"Nordisk Tidsskrift for Helseforskning"},{"key":"2024103013305080200_dlae155-B9","doi-asserted-by":"publisher","first-page":"f1518","DOI":"10.1136\/bmj.f1585","article-title":"Outpatient parenteral antimicrobial therapy","volume":"346","author":"Chapman","year":"2013","journal-title":"BMJ"},{"key":"2024103013305080200_dlae155-B10","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1016\/j.ijid.2020.11.176","article-title":"Stability of antimicrobial agents in an elastomeric infusion pump used for outpatient parenteral antimicrobial therapy","volume":"103","author":"Akahane","year":"2021","journal-title":"Int J Infect Dis"},{"key":"2024103013305080200_dlae155-B11","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1093\/jac\/dkw582","article-title":"Antibiotic stability related to temperature variations in elastomeric pumps used for outpatient parenteral antimicrobial therapy (OPAT)","volume":"72","author":"Voumard","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"2024103013305080200_dlae155-B12","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1093\/jac\/dkh146","article-title":"Stability of benzylpenicillin during continuous home intravenous therapy","volume":"53","author":"Vella-Brincat","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"2024103013305080200_dlae155-B13","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.cmi.2018.08.021","article-title":"Hypersensitivity reactions with prolonged infusions of \u03b2-lactams?","volume":"25","author":"Fjeld","year":"2019","journal-title":"Clin Microbiol Infect"},{"key":"2024103013305080200_dlae155-B14","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1016\/S0140-6736(82)91991-2","article-title":"Effect of storage of penicillin-G solutions on sensitisation to penicillin-G after intravenous administration","volume":"1","author":"Neftel","year":"1982","journal-title":"Lancet"}],"container-title":["JAC-Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jacamr\/article-pdf\/6\/5\/dlae155\/60198233\/dlae155.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jacamr\/article-pdf\/6\/5\/dlae155\/60198233\/dlae155.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T18:59:46Z","timestamp":1730314786000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jacamr\/article\/doi\/10.1093\/jacamr\/dlae155\/7820718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,3]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jacamr\/dlae155","relation":{},"ISSN":["2632-1823"],"issn-type":[{"value":"2632-1823","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,9,3]]},"article-number":"dlae155"}}