{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:38:48Z","timestamp":1769693928405,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T00:00:00Z","timestamp":1729209600000},"content-version":"vor","delay-in-days":45,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017642","name":"Plan Estatal de Investigacion Cientifica y t\u00e9cnica y de Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PI19\/01043"],"award-info":[{"award-number":["PI19\/01043"]}],"id":[{"id":"10.13039\/501100017642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017642","name":"Plan Estatal de Investigacion Cientifica y t\u00e9cnica y de Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PI22\/1045"],"award-info":[{"award-number":["PI22\/1045"]}],"id":[{"id":"10.13039\/501100017642","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023961","name":"CIBER de Enfermedades Infecciosas","doi-asserted-by":"publisher","award":["CB21\/13\/00084"],"award-info":[{"award-number":["CB21\/13\/00084"]}],"id":[{"id":"10.13039\/501100023961","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CB21\/13\/00084"],"award-info":[{"award-number":["CB21\/13\/00084"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["JR18\/00034"],"award-info":[{"award-number":["JR18\/00034"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Chronic bronchopulmonary infection due to MRSA in people with cystic fibrosis (pwCF) has been associated with accelerated decline in lung function, increased hospitalizations and increased mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Material and methods<\/jats:title>\n                  <jats:p>We studied microbiological and genomic characteristics of MRSA isolates recovered from pwCF in two Spanish multicentre studies (2013, 2021). Antimicrobial susceptibility was performed. WGS was carried out to determine population structure [MLST, spa-typing, staphylococcal cassette chromosome mec (SCCmec)], resistome and virulome. Clinical charts of MRSA-infected and MRSA-non-infected pwCF were also reviewed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>MRSA infection prevalence decreased between 2013 (29\/341, 8.5%) and 2021 (21\/326, 6.4%) (P\u200a=\u200a0.378). Differences in lung function were observed between infected and non-infected patients (P\u200a&amp;lt;\u200a0.005). A higher prevalence of hospital-acquired (HA) clones was found compared with community-acquired (CA) clones (2013: 67% versus 33%; and 2021: 71% versus 29%). Overall, we noted clustering of isolates based on year of sampling, type of acquisition and clonal complex (CC). HA-MRSA population was dominated by CC5, with ST125-MRSA-IVc-t067 the most prevalent lineage (37%). A higher clonal diversity was detected among CA-MRSA. One Panton\u2013Valentine leucocidin (PVL)-positive strain (ST8-MRSA-IV) and three strains of porcine origin (two ST398-MRSA-V-t011, one ST398-MRSA-V-t8567) were found. Additionally, acquired resistance genes (n\u200a=\u200a24) were detected, including the cfr gene conferring linezolid resistance. A higher gentamicin resistance was found in 2021 (42%) compared with 2013 (7%) (P\u200a=\u200a0.046), associated with the aac(6\u2032)-aph(2\u2033) gene.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Despite a decrease in MRSA prevalence, we showed its potential impact on CF severity and progression. Moreover, we observed great genotypic and phenotypic diversity in MRSA isolates from pwCF as well as an MDR trait.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jacamr\/dlae160","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T13:05:07Z","timestamp":1729256707000},"source":"Crossref","is-referenced-by-count":3,"title":["Genomic characterization of MRSA recovered from people with cystic fibrosis during two Spanish multicentre studies (2013 and 2021)"],"prefix":"10.1093","volume":"6","author":[{"given":"Ainhize","family":"Maruri-Aransolo","sequence":"first","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario Ram\u00f3n y Cajal and Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS) , Madrid, 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Microbiolog\u00eda, Hospital Universitario Ram\u00f3n y Cajal and Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS) , Madrid, Espa\u00f1a"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Dolores","family":"Pastor-Vivero","sequence":"additional","affiliation":[{"name":"Servicio de neumolog\u00eda pedi\u00e1trica, Hospital Universitario Cruces and IIS Biobizkaia , Bizkaia ,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Mondejar-Lopez","sequence":"additional","affiliation":[{"name":"Servicio de neumolog\u00eda pedi\u00e1trica, Hospital Cl\u00ednico Universitario Virgen de la Arrixaca , Murcia, Espa\u00f1a"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amparo","family":"Sol\u00e9","sequence":"additional","affiliation":[{"name":"Servicio de neumolog\u00eda, Hospital Universitario y Polit\u00e9cnico La Fe and Universitat de Valencia , Valencia, Espa\u00f1a"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1675-3173","authenticated-orcid":false,"given":"Rafael","family":"Cant\u00f3n","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario Ram\u00f3n y Cajal and Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS) , Madrid, Espa\u00f1a"},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid, Espa\u00f1a"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan de Dios","family":"Caballero-P\u00e9rez","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda, Hospital Universitario Ram\u00f3n y Cajal and Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS) , Madrid, Espa\u00f1a"},{"name":"CIBER de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III , Madrid, 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