{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T20:11:30Z","timestamp":1774469490052,"version":"3.50.1"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T00:00:00Z","timestamp":1730937600000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of this study is to describe the real-life use of temocillin in bone and joint infections (BJI).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Patients and methods<\/jats:title>\n                  <jats:p>We performed a monocentric retrospective study, including all patients treated by temocillin for a BJI due to extended spectrum \u03b2-lactamase-producing Enterobacterales (ESBL-E) between 1 January 2015 and 31 December 2022. Outcomes were evaluated at least 3\u2005months after the end of antimicrobial treatment. Clinical cure was defined as the absence of recurrence of BJI during follow-up among patients who completed at least 7\u2005days of temocillin. If the patient discontinued temocillin due to ineffectiveness, the outcome was considered to be unfavourable. Seventeen patients were treated with temocillin for ESBL-E associated BJI during the study period.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Infections included osteomyelitis of the foot (7\/17; 41.2%), femoral osteomyelitis (4\/17; 23.5%), disco-vertebral infections (2\/17; 11.8%), total knee prosthesis infections (2\/17; 11.8%) and total hip prosthesis infections (2\/17; 11.8%). All patients except one (n\u200a=\u200a16) had surgical management of the infection. The main bacteria identified were the Enterobacter cloacae complex (n\u200a=\u200a9) and Klebsiella pneumoniae (n\u200a=\u200a5). The median daily dose was 6\u2005g for a median duration of 42\u2005days (IQR 14\u201342\u2005days). The median duration of follow-up was 12\u2005months (IQR 5.25\u201314.5). Overall, 12 patients completed at least 3\u2005months of follow-up, and clinical cure was observed in eight of them (8\/12; 66.7%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>So far, this is the first report of BJI successfully treated with temocillin. This suggests that temocillin may be an alternative to treat BJI involving difficult-to-treat Enterobacterales when oral therapy is not available.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jacamr\/dlae171","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T06:58:58Z","timestamp":1730962738000},"source":"Crossref","is-referenced-by-count":4,"title":["Real-life use of temocillin in the treatment of bone and joint infections due to extended spectrum \u03b2-lactamase-producing Enterobacterales"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0043-7336","authenticated-orcid":false,"given":"Marin","family":"Lahouati","sequence":"first","affiliation":[{"name":"CHU de Bordeaux, Service de Pharmacie Clinique , F-33076 Bordeaux ,","place":["France"]},{"name":"Universit\u00e9 de Bordeaux, INSERM, Biologie des maladies cardiovasculaires, U1034 , F-33600 Pessac ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Brousse","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Centre de r\u00e9f\u00e9rence infections ost\u00e9o-articulaires complexes (Crioac GSO) et service des maladies infectieuses et tropicales , F-33076 Bordeaux ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasco","family":"Dias Meireles","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Service de Pharmacie Clinique , F-33076 Bordeaux ,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurine","family":"Rignol","sequence":"additional","affiliation":[{"name":"CHU de Bordeaux, Service de Pharmacie Clinique , F-33076 Bordeaux 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