{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:07:39Z","timestamp":1779296859168,"version":"3.51.4"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":57,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Antimicrobial resistance (AMR) is a global threat to public health. Misuse or overuse of antimicrobials contributes to the emergence of AMR. Data on antimicrobial prescribing represent the cornerstone for guiding antimicrobial stewardship strategies. This study aimed to assess the use, indications, classification, and quality indicators of antimicrobials prescribed to patients in four tertiary hospitals in Niger.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This cross-sectional study used the methodology for Global Point Prevalence Surveys in tertiary hospitals between January and April 2024. Hospital records of all inpatients on admission at 08:00 hours on a specific day were reviewed for antimicrobial use during the survey.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The overall prevalence of antibiotic use across hospitals was 54.5% (n\u200a=\u200a470\/862), ranging between 66.2% (n\u200a=\u200a149\/234) and 44.3% (n\u200a=\u200a183\/258). Most antibiotics used were antibacterials (89.0%, n\u200a=\u200a637). Third-generation cephalosporins (48.2%, 307\/637), imidazole derivatives (14.7%, 105\/716), penicillins with extended spectrum (9.6%, 69\/716), and fluoroquinolones (6.1%, 44\/716) were the most commonly prescribed classes of antibiotics. Most antibiotics (84.9%, n\u200a=\u200a608) were prescribed to treat community-acquired infections, while surgical prophylaxis accounted for 6.4% (n\u200a=\u200a47\/716). Most antibiotics (96.1%; n\u200a=\u200a688\/716) were used empirically, and less than a quarter (20.7%) of antibiotics prescribed had a documented stop\/review date recorded. Only, 4.2% (n\u200a=\u200a31\/716) of prescribed antibiotics had cultures and susceptibility testing requested.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study shows that antibiotic prescription rates are high in tertiary hospitals, with relatively high use of third-generation cephalosporins. Most antibiotics were empirically used and not guided by culture and susceptibility testing. These results could be the subject of key interventions for hospital antibiotic stewardship strategies in Niger.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jacamr\/dlae175","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T18:52:22Z","timestamp":1730314342000},"source":"Crossref","is-referenced-by-count":4,"title":["Antimicrobial use in hospitalized patients: a point prevalence survey across four tertiary hospitals in Niger"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-7502-7031","authenticated-orcid":false,"given":"Ounoussa","family":"Tapha","sequence":"first","affiliation":[{"name":"Laboratoire National de R\u00e9f\u00e9rence sur la R\u00e9sistance aux Anti-Microbiens, H\u00f4pital National Amirou Boubacar Diallo , Niamey ,","place":["Niger"]},{"name":"D\u00e9partement Sant\u00e9 Environnement, Institut R\u00e9gional de Sant\u00e9 Publique Comlan Alfred Quenum (IRSP) , Ouidah 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