{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:38:55Z","timestamp":1790123935339,"version":"4.0.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Recovery and Resilience Plan"},{"name":"European Union - Next Generation EU","award":["Project 2022A7LA2W"],"award-info":[{"award-number":["Project 2022A7LA2W"]}]},{"name":"European Union - Next Generation EU","award":["CUP C53D23006050006"],"award-info":[{"award-number":["CUP C53D23006050006"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Antibiotics are the most prescribed drugs for children worldwide, but overuse and misuse have led to an increase in antibiotic resistance. Antimicrobial stewardship programmes (ASPs) have proven feasible in reducing inappropriate antimicrobial use. The study aimed at evaluating the impact and sustainability of an ASP with multiple interventions over 8 years.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This quasi-experimental study was conducted between 2014 and 2022 in the paediatric acute care unit of Padua University Hospital. Demographic and clinical data were retrieved from the electronic clinical records. Daily prescriptions were collected and analysed based on the AWaRe classification and using days of therapy (DOT) out of 1000 patient days (DOT\/1000PDs). The primary outcome was to assess the change in overall antibiotic consumption and of access and watch antibiotics, stratifying patients with and without comorbidities. Trends in antibiotic consumption (DOTs\/1000PD) were assessed using joinpoint regression analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Findings<\/jats:title>\n                  <jats:p>A total of 3118 children were included. Total antibiotic consumption remained stable and low in patients without comorbidities, \u223c300 DOT\/1000PDs, whereas a statistically significant constant reduction was observed in children with comorbidities, from almost 500 DOT\/1000PPDs to &amp;lt;400 DOT\/1000PDs. Access consumption increased in both groups of patients, whereas watch consumption constantly decreased, although statistically significant only in children with comorbidities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Interpretation<\/jats:title>\n                  <jats:p>Implementing a multistep ASP has proven feasible and sustainable in improving antibiotic prescriptions for previously healthy and fragile children. All the implemented interventions were low cost, and with efficient use of resources, ensuring an ASP that was effective, practical, and easily replicable and implementable in various healthcare settings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jacamr\/dlae181","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T10:51:19Z","timestamp":1730890279000},"source":"Crossref","is-referenced-by-count":5,"title":["Impact of a multifaceted antibiotic stewardship programme in a paediatric acute care unit over 8 years"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0600-7745","authenticated-orcid":false,"given":"Giulia","family":"Brigadoi","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department for Women\u2019s and Children\u2019s Health, University of Padua , Via Giustiniani 3, 35128 Padua 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Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Rossin","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Department for Women\u2019s and Children\u2019s Health, University of Padua , Via Giustiniani 3, 35128 Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9633-873X","authenticated-orcid":false,"given":"Lorenzo","family":"Chiusaroli","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department for Women\u2019s and Children\u2019s Health, University of Padua , Via Giustiniani 3, 35128 Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia Camilla","family":"Demarin","sequence":"additional","affiliation":[{"name":"Department for Women\u2019s and Children\u2019s Health, University of Padua , Via Giustiniani 3, 35128 Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Tesser","sequence":"additional","affiliation":[{"name":"Department for Women\u2019s and Children\u2019s Health, University of Padua , Via Giustiniani 3, 35128 Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Maestri","sequence":"additional","affiliation":[{"name":"Department for Women\u2019s and Children\u2019s Health, University of Padua , Via Giustiniani 3, 35128 Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Tirelli","sequence":"additional","affiliation":[{"name":"Rheumatology Unit, Department of Woman\u2019s and Child\u2019s Health, University of Padova , Via Giustiani 3, 35128 Padua ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1004-515X","authenticated-orcid":false,"given":"Elena","family":"Carrara","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Diagnostic and Public Health, University of Verona , Verona 37134 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Tacconelli","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Diagnostic and Public Health, University of Verona , Verona 37134 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Bressan","sequence":"additional","affiliation":[{"name":"Pediatric Emergency Department, Department for Women\u2019s and Children\u2019s Health, University of Padua , Via Giustiniani 3, 35128 Padua 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