{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:47:13Z","timestamp":1780505233609,"version":"3.54.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T00:00:00Z","timestamp":1739491200000},"content-version":"vor","delay-in-days":50,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100020955","name":"GlaxoSmithKline Biologicals SA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020955","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Acute otitis media (AOM) is a leading cause of healthcare visits, antibiotic prescription and complications in children aged under 5\u2005years. Following the introduction of pneumococcal conjugate vaccines (PCVs), non-typeable Haemophilus influenzae (NTHi) has become the most common causative agent for AOM, followed by Streptococcus pneumoniae and Moraxella catarrhalis. PCVs are not yet included in the National Immunization Program in Vietnam.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To determine the frequency and characteristics of the pathogens related to AOM in Vietnam in children \u22645\u2005years old.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a cross-sectional study performed at the Vietnam National Children\u2019s Hospital from October 2021 to December 2023 in children \u22645\u2005years old diagnosed with acute suppurative otitis media. Clinical features of the children were described. Pathogens of interest were identified by culture or real-time PCR (rtPCR). The antibiotic susceptibility profiles of H. influenzae and S. pneumoniae isolates were determined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 482 children \u22645\u2005years old were included, of which 70.8% were \u22642\u2005years old and 61% had an history of AOM. The most frequent bacteria isolated were H. influenzae (52.1%, 99.6% of which were NTHi) and S. pneumoniae (41.1%). Most S. pneumoniae isolates were resistant to azithromycin, clarithromycin and cefuroxime. Most H. influenzae isolates were resistant to amoxicillin, cefixime, cefuroxime, azithromycin and clarithromycin.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The pathogens most frequently associated with AOM in this study were in line with previous findings. Many isolates were resistant to commonly given oral antibiotics. These results can inform decision-making on AOM prevention and treatment strategies in Vietnam.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jacamr\/dlaf006","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T11:22:40Z","timestamp":1737112960000},"source":"Crossref","is-referenced-by-count":1,"title":["Characteristics and antimicrobial susceptibility of bacteria causing acute otitis media in children at Vietnam National Children\u2019s Hospital: a cross-sectional study"],"prefix":"10.1093","volume":"7","author":[{"given":"H\u1ed3ng \u0110i\u1ec7p","family":"\u0110\u1ed7","sequence":"first","affiliation":[{"name":"Department of Ear - Nose - Throat, Vietnam National Children\u2019s Hospital , Hanoi ,","place":["Vietnam"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minh \u0110i\u1ec3n","family":"Tr\u1ea7n","sequence":"additional","affiliation":[{"name":"Board of Director, Vietnam National Children's Hospital , Hanoi 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