{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T06:43:13Z","timestamp":1780987393944,"version":"3.54.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T00:00:00Z","timestamp":1749427200000},"content-version":"vor","delay-in-days":41,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Australian National Health and Medical Research Council Postgraduate Scholarship","award":["APP1169220"],"award-info":[{"award-number":["APP1169220"]}]},{"name":"Early Career Fellowship","award":["GNT1141398"],"award-info":[{"award-number":["GNT1141398"]}]},{"name":"Practitioner Fellowship","award":["APP1117940"],"award-info":[{"award-number":["APP1117940"]}]},{"name":"GRAM"},{"name":"United Kingdom\u2019s Department of Health and Social Care"},{"name":"Fleming Fund"},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["209142\/Z\/17\/Z"],"award-info":[{"award-number":["209142\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill and Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1176062"],"award-info":[{"award-number":["OPP1176062"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Antimicrobial resistance (AMR) is a global health threat, with third-generation cephalosporin\u2013resistant (3GCR) and carbapenem-resistant infections of particular concern. There is currently a lack of genomic data on AMR organisms in the Pacific region.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We aimed to address this gap by examining the genetic diversity of a collection of 788 Gram-negative and Gram-positive clinical isolates collected between July 2020 and October 2022 from a single hospital in Suva, Fiji. We sampled sensitive and resistant isolates, focusing on 3GCR and carbapenem-resistant Gram-negatives, and methicillin-resistant Staphylococcus and vancomycin-resistant Enterococcus.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We detected 29 distinct species across 12 different genera. Amongst Gram-negative genomes, Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii and Pseudomonas aeruginosa were the most common. Carbapenem resistance was mostly detected in A. baumannii ST2 and P. aeruginosa ST773, with both STs carrying NDM-1 and showing evidence of transmission within Fiji. Carbapenem resistance was relatively rare amongst the Enterobacterales; however, we observed evidence of transmission of OXA-232\u2013carrying K. pneumoniae ST395 and NDM-7 E. coli ST410. For Gram-positive bacteria, Staphylococcus aureus ST1 was the dominant clone, and phylogenetic analysis revealed a single clade harbouring the majority of Fijian genomes, with close relationships to genomes from neighbouring Samoa. Enterococcus was relatively rare, with only 22 genomes detected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study provides crucial genomic data on AMR organisms in Fiji, highlighting the diversity of resistant species in the region. Local transmission of four carbapenem-resistant clones within Fiji was observed, underscoring the importance of local spread of these resistant strains.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jacamr\/dlaf058","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T10:54:50Z","timestamp":1749466490000},"source":"Crossref","is-referenced-by-count":2,"title":["Genomic diversity of clinically relevant bacterial pathogens from an acute care hospital in Suva, Fiji"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9661-5293","authenticated-orcid":false,"given":"Jane","family":"Hawkey","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, the Alfred Hospital and School of Translational Medicine, Monash University , Melbourne 3004 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Colonial War Memorial Hospital , Suva ,","place":["Fiji"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Litia","family":"Tudravu","sequence":"additional","affiliation":[{"name":"Pathology Department, Colonial War Memorial Hospital , Suva ,","place":["Fiji"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Pragastis","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, the Alfred Hospital and School of Translational Medicine, Monash University , Melbourne 3004 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Wisniewski","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, the Alfred Hospital and School of Translational Medicine, Monash University , Melbourne 3004 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W","family":"Jenney","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, the Alfred Hospital and School of Translational Medicine, Monash University , Melbourne 3004 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton Y","family":"Peleg","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, the Alfred Hospital and School of Translational Medicine, Monash University , Melbourne 3004 ,","place":["Australia"]},{"name":"Infection Program, Monash Biomedicine Discovery Institute, Department of Microbiology, Monash University , Clayton ,","place":["Australia"]},{"name":"Centre to Impact AMR, Monash University , Clayton 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