{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T22:53:58Z","timestamp":1770332038932,"version":"3.49.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":27,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The blaSCO-1 gene, which codes for a carbenicillinase, is an uncommon \u03b2-lactamase. To the best of our knowledge, we report the first instance of a Klebsiella pneumoniae clinical high-risk isolate carrying blaSCO-1 in Peru.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To characterize a K. pneumoniae clinical isolate carrying blaSCO-1 in Peru, isolated from a tertiary care hospital in Lima, Peru.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Susceptibility to amoxicillin\/clavulanic acid, amoxicillin\/sulbactam, piperacillin\/tazobactam, aztreonam, ceftriaxone, cefotaxime, ceftazidime, ceftazidime\/avibactam, cefepime, imipenem, meropenem, ciprofloxacin, trimethoprim\/sulfamethoxazole, gentamicin, amikacin and tigecycline was determined using the Kirby\u2013Bauer disc diffusion method. Detection of blaSCO-1 was established by Illumina WGS and bioinformatic analyses. All the publicly available genomes from K. pneumoniae carrying blaSCO-1 from the American continent were downloaded from the NCBI Isolates browser for assessment of phylogenetic comparisons.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The isolate showed resistance to all the tested antibiotics except for ceftazidime\/avibactam, carbapenems and tigecycline. Illumina WGS showed the presence of blaSCO-1 and blaOXA-1, blaSHV-28, blaTEM-1, blaCTX-M-15, as well as genes associated with resistance to quinolones, fosfomycin, aminoglycosides, sulphonamides, trimethoprim and phenicols. Moreover, the isolate was ST307, a high-risk clone of K. pneumoniae usually associated with blaCTX-M-15 and\/or carbapenemases. Notwithstanding, the latter were not found on this isolate. Phylogenetic relationships were established by comparisons with 19 K. pneumoniae genomes carrying blaSCO-1 from other countries in the Americas, revealing at least three different clades.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study highlights the importance of genomic surveillance of uncommon antimicrobial resistance genes such as blaSCO-1, which might contribute to further antimicrobial resistance levels in this country.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jacamr\/dlaf089","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T01:53:36Z","timestamp":1748224416000},"source":"Crossref","is-referenced-by-count":1,"title":["Detection of rare \u03b2-lactamase <i>bla<\/i>SCO-1 from a <i>Klebsiella pneumoniae<\/i> high-risk clone in Peru"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4832-9369","authenticated-orcid":false,"given":"Luciano A","family":"Palomino-Kobayashi","sequence":"first","affiliation":[{"name":"Programa de Doctorado en Ciencias de la Salud, Facultad de Medicina, Universidad Nacional Mayor de San Marcos , Lima ,","place":["Per\u00fa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Ego\u00e1vil-Espejo","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Din\u00e1micas y Epidemiolog\u00eda de la Resistencia a Antimicrobianos\u2014\u2018One Health\u2019, Universidad Cient\u00edfica del Sur , Lima ,","place":["Per\u00fa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6617-6402","authenticated-orcid":false,"given":"Gina","family":"Salvador-Luj\u00e1n","sequence":"additional","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda, Hospital Militar Central , Lima ,","place":["Per\u00fa"]},{"name":"Laboratorio de Ecolog\u00eda Microbiana, Facultad de Ciencias Biol\u00f3gicas, Universidad Nacional Mayor de San Marcos , Lima ,","place":["Per\u00fa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Y\u00e1\u00f1ez","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Salud , Lima ,","place":["Per\u00fa"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1437-5607","authenticated-orcid":false,"given":"Ronnie G","family":"Gavil\u00e1n","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Salud , Lima ,","place":["Per\u00fa"]},{"name":"Escuela Profesional de Medicina Humana, Universidad Privada San Juan Bautista , Lima ,","place":["Peru"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria J","family":"Pons","sequence":"additional","affiliation":[{"name":"Grupo de Investigaci\u00f3n en Din\u00e1micas y 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