{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:04:44Z","timestamp":1753877084895,"version":"3.41.2"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T00:00:00Z","timestamp":1750896000000},"content-version":"vor","delay-in-days":58,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Bloodstream infections due to yeast are associated with a high mortality rate. There is a lack of data that evaluate the real-world sensitivity of a rapid detection system for bloodstream infections due to yeast or the impact of these results on antimicrobial stewardship. The aim of this study was to evaluate the sensitivity of an ePlex panel (BCID-FP) for rapid detection of yeast from a positive blood culture bottle and to evaluate the impact of these rapid results on antifungal escalation or de-escalation. We evaluated 63 episodes of fungemia and found a sensitivity of 94%, lower than the 99%\u2013100% stated in the package insert. Most common pathogens were Candida glabrata (36%), Candida albicans (24%), Candida parapsilosis (10%) and Candida krusei (10%). Only 57.1% of BCID-FP results lead to a change in antifungal therapy, most of which was initiation of an echinocandin. The real-world sensitivity of the BCID-FP panel was lower than anticipated and rarely led to de-escalation of antifungal therapy.<\/jats:p>","DOI":"10.1093\/jacamr\/dlaf110","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T06:25:11Z","timestamp":1750919111000},"source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of a rapid identification panel for fungemia"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4282-4134","authenticated-orcid":false,"given":"Emily A","family":"Siegrist","sequence":"first","affiliation":[{"name":"Department of Pharmacy, OU Health , 700 NE 13th Str., Oklahoma City, OK 73104 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5657-7069","authenticated-orcid":false,"given":"Bryan P","family":"White","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, OU Health , 700 NE 13th Str., Oklahoma City, OK 73104 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Robison","sequence":"additional","affiliation":[{"name":"Department of Pathology, OU Health , P.O. Box 26901, BMSB 451, Oklahoma City, OK 73126-0901 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy","family":"McCloskey","sequence":"additional","affiliation":[{"name":"Department of Pathology, OU Health , P.O. Box 26901, BMSB 451, Oklahoma City, OK 73126-0901 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Alkozah","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Diseases Section, OU Health Sciences Center , 800 Stanton L Young Blvd, Oklahoma City, OK 73104 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson","family":"Agudelo Higuita","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Diseases Section, OU Health Sciences Center , 800 Stanton L Young Blvd, Oklahoma City, OK 73104 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Wilson Dib","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Diseases Section, OU Health Sciences Center , 800 Stanton L Young Blvd, Oklahoma City, OK 73104 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-8929","authenticated-orcid":false,"given":"Joseph","family":"Sassine","sequence":"additional","affiliation":[{"name":"Department of Medicine, Infectious Diseases Section, OU Health Sciences Center , 800 Stanton L Young Blvd, Oklahoma City, OK 73104 ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"author":"CDC","key":"2025062602250768300_dlaf110-B1"},{"key":"2025062602250768300_dlaf110-B2","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1177\/10600280231175201","article-title":"Candidemia in adult patients in the ICU: a reappraisal of susceptibility testing and antifungal therapy","volume":"58","author":"Chastain","year":"2024","journal-title":"Ann Pharmacother"},{"volume-title":"ePlex Blood Culture Identification Fungal Pathogen Panel Package Insert","year":"2020","key":"2025062602250768300_dlaf110-B3"},{"key":"2025062602250768300_dlaf110-B4","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1093\/cid\/ciy827","article-title":"Isavuconazole versus caspofungin in the treatment of candidemia and other invasive Candida infections: the ACTIVE trial","volume":"68","author":"Kullberg","year":"2019","journal-title":"Clin Infect Dis"},{"key":"2025062602250768300_dlaf110-B5","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1093\/cid\/cis021","article-title":"Impact of treatment strategy on outcomes in patients with candidemia and other forms of invasive candidiasis: a patient-level quantitative review of randomized trials","volume":"54","author":"Andes","year":"2012","journal-title":"Clin Infect Dis"}],"container-title":["JAC-Antimicrobial Resistance"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jacamr\/article-pdf\/7\/3\/dlaf110\/63582738\/dlaf110.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jacamr\/article-pdf\/7\/3\/dlaf110\/63582738\/dlaf110.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T06:25:12Z","timestamp":1750919112000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jacamr\/article\/doi\/10.1093\/jacamr\/dlaf110\/8173978"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":5,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,4,29]]}},"URL":"https:\/\/doi.org\/10.1093\/jacamr\/dlaf110","relation":{},"ISSN":["2632-1823"],"issn-type":[{"type":"electronic","value":"2632-1823"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,4,29]]},"article-number":"dlaf110"}}