{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:44:58Z","timestamp":1790441098312,"version":"4.1.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the trend in macrolide ambulatory use among children in Switzerland following a global surge in Mycoplasma pneumoniae infections in late 2023.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We conducted a population-based interrupted time-series analysis of macrolide use in Swiss children aged 0 to 11\u2005years from 2018 to 2023 using national ambulatory antibiotic claims data. The main outcome was the evolution of macrolide use in ambulatory setting, expressed as monthly defined daily doses (DDD) per 1000 children. We defined two time periods: (i) the pre-autumn 2023 period, before M. pneumoniae detections increased in Switzerland (1 January 2018 to 30 September 2023) and (ii) the autumn 2023 period, after M. pneumoniae detections increased in Switzerland (1 October 2023 to 31 December 2023). We built a quasi-Poisson regression model to estimate the changes in macrolide monthly DDD per 1000 children from October 2023 in Switzerland. The model accounted for temporal trends before the WHO alert and for the seasonal pattern of macrolide prescriptions. We analysed amoxicillin use as a control outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We found a significant increase in macrolides use expressed in monthly DDD per 1000 children aged 0 to 11\u2005years from October 2023 in Switzerland [+235% (95%CI +139%\u2013+368%), P value\u200a&amp;lt;\u200a0.001]. The use of amoxicillin remained stable in both age groups after October 2023.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We found a 3-fold increase in macrolide monthly DDD per 1000 children in autumn 2023 in the context of a global increase in M. pneumoniae infections. Monitoring macrolide resistance and promoting appropriate prescription practices are essential.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jacamr\/dlaf123","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T07:38:09Z","timestamp":1751355489000},"source":"Crossref","is-referenced-by-count":2,"title":["Surge in macrolide dispensing to Swiss children in a period of increased incidence of <i>Mycoplasma pneumoniae<\/i> detection: an interrupted time-series analysis"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0063-1510","authenticated-orcid":false,"given":"Manon","family":"Jaboyedoff","sequence":"first","affiliation":[{"name":"Unit of Pediatric Infectious Diseases and Vaccinology, Service of Pediatrics, Department Women-Mother-Child, Lausanne University Hospital and University of Lausanne , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2475-8057","authenticated-orcid":false,"given":"Catherine","family":"Pl\u00fcss-Suard","sequence":"additional","affiliation":[{"name":"Swiss Centre for Antibiotic Resistance, Institute for Infectious Diseases, University of Bern , Bern ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4312-9803","authenticated-orcid":false,"given":"Patrick M","family":"Meyer Sauteur","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases and Hospital Epidemiology, Children\u2019s Research Center, University Children\u2019s Hospital Zurich, University of Zurich , Zurich ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8276-7082","authenticated-orcid":false,"given":"Stephen P","family":"Jenkinson","sequence":"additional","affiliation":[{"name":"Institute of Primary Health Care (BIHAM), University of Bern , Bern 3012 ,","place":["Switzerland"]},{"name":"Swiss Pharmacists Association PharmaSuisse , Bern-Liebefeld 3097 ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7973-6445","authenticated-orcid":false,"given":"Alessandro","family":"Cassini","sequence":"additional","affiliation":[{"name":"Cantonal Doctor Office, Public Health Department, Canton of Vaud , Lausanne ,","place":["Switzerland"]},{"name":"Service of Infectious Diseases, Department of Internal Medicine, Lausanne University Hospital and University of Lausanne , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2490-8174","authenticated-orcid":false,"given":"No\u00e9mie","family":"Boillat-Blanco","sequence":"additional","affiliation":[{"name":"Service of Infectious Diseases, Department of Internal Medicine, Lausanne University Hospital and University of Lausanne , Lausanne ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1967-8255","authenticated-orcid":false,"given":"Pierre Alex","family":"Crisinel","sequence":"additional","affiliation":[{"name":"Unit of Pediatric Infectious Diseases and Vaccinology, Service of Pediatrics, Department Women-Mother-Child, Lausanne University Hospital and University of Lausanne , Lausanne 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